Javier Castro Alvariño

Universidade da Coruña

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Ramón Vázquez Dourado

Universidade da Coruña

Leticia García Diéguez

Universidade da Coruña

Cristian R. Munteanu

Universidade da Coruña

Rafael García-Ramón

Universitat de València

M. Lanuza

Hospital Universitario Virgen de la Arrixaca

José M. Vázquez-Naya

Universidade da Coruña

José Antonio Díaz Peromingo

Complejo Hospitalario Universitario de Santiago

Alejandro Pazos

Universidade da Coruña

Pedro Carpintero Briones

Complejo Hospitalario Universitario de Ferrol

Carmen Gómez‐Roldán

Hospital General Universitario de Albacete

Cooperative Institutions

Complexo Hospitalario Universitario A Coruña

Universidade da Coruña

Servicio Gallego de Salud

Universidade de Santiago de Compostela

Instituto de Investigación Biomédica de A Coruña

Complejo Hospitalario Universitario de Santiago

Instituto de Investigación Sanitaria de Santiago

University Hospital Complex Of Vigo

Complejo Hospitalario Universitario de Ferrol

Instituto de Salud Carlos III

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Multidisciplinary committee for a comprehensive approach to CRC patients

Elsevier eBooks (2021)

Ramón Vázquez Dourado Pedro Carpintero Briones Javier Castro Alvariño

Clinical Practice

Multidisciplinary team

10.1016/b978-0-323-90055-3.00039-9

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Prevalence and risk factors for hepatitis C virus infection in continuous ambulatory peritoneal dialysis patients

Nephrology Dialysis Transplantation (1996)

José Luis Górriz Álvaro Flores de Miguel Rafael García-Ramón Javier Pérez-Contreras Jocelyn Olivares

Studies on hepatitis C virus antibodies (Anti-HCV) in CAPD patients are scarce and include a small number of patients. Nevertheless, risk factors related to Anti-HCV in these patients are still subject to controversy. To analyse the incidence and risk factors associated with the presence of Anti-HCV in CAPD patients. We studied 255 patients from five different treatment centres of our region. The analysis was repeated after excluding 161 patients who had previously received haemodialysis treatment at least once. Anti-HCV testing was made by the 2nd-generation ELISA. As a supplementary test we used RIBA-4 in three centers and INNOLIA in the other two. Risk factors were analysed using logistic regression model for multivariate analysis. In the whole group, 29 patients (11.4%) were anti-HCV positive. Logistic regression analysis determined the following variables as independent risk factors: hepatitis previous to CAPD (P<0.0001, odds ratio (OR): 44.9), Anti HBc positivity (P=;0.019, OR: 9.24), blood transfusions previous to CAPD (P=;0.015, OR: 1.05) and CAPD duration (P=0.025, OR: 1.02). When patients who had previously undergone haemodialysis were excluded, the prevalence of HCV antibodies was 8.5% (8/94). In this group multivariate analysis showed that Anti-HCV positivity correlated with hepatitis previous to CAPD (P<0.0003, OR: 126) and Anti HBc positivity (P=0.002, OR: 41.9). Our prevalence of hepatitis C virus (HCV) infection in CAPD patients was lower than other renal replacement therapy modalities, and correlated to events occurring mainly before starting CAPD treatment. This technique could be considered as low risk for HCV infection.

Hepatitis C

10.1093/ndt/11.6.1109

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I ICWM: Inflammatory bowel disease in relationship with gut microbiota. Dr. Javier Castro Alvariño

Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition (2019)

Javier Castro Alvariño

Existe una relación entre la microbiota y EII. Es debido a esto por lo quees necesario establecer las asociaciones actuales de la disbiosis en la EII yconsiderar el papel de la microbiota intestinal en la patogenia de la EII, ası́como discutir el intervencionismo potencial con intención terapéutica sobrela microbiota en pacientes con EII. Link al vı́deo: https://www.youtube.com/watch?v=CRmwaC_q2to

Inflammatory Bowel Diseases

10.3390/mol2net-05-06751

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Contributors

Elsevier eBooks (2021)

José Francisco Noguera Aguilar Mohammed Alhayek-Aí Pedro A. Alonso Aguirre Paula Álvarez-Chaver Sara Alvarez-Gonzalez

10.1016/b978-0-323-90055-3.09988-9

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Colonoscopy: Technique and quality factors

Elsevier eBooks (2021)

Ramón Vázquez Dourado Leticia García Diéguez Javier Castro Alvariño

Chromoendoscopy

Bowel preparation

Colorectal cancer screening

10.1016/b978-0-323-90055-3.00051-x

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Tratamiento con 5-asa de la colitis ulcerosa ¿qué hay de nuevo?

Javier Castro Alvariño

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The influence of several factors that intervene in hemodialysis on serum levels of triglycerides and free fatty acids.

PubMed (1979)

Ana Pérez-García M Bretó Javier Castro Alvariño B Alegre Cruz Jm

The effect of the administration of heparin and glucose, in doses and sequence similar to those of hemodialysis, on serum free fatty acids and triglycerides, was studied in eight patients with chronic renal failure who had not undergone hemodialysis. The results are compared with the action exerted by hemodialysis on the same parameters. During hemodialysis, the values of triglycerides are not significantly different from those obtained at similar intervals after the administration of glucose and/or heparin, with the exception that the values obtained five hours after beginning hemodialysis are lower than those obtained five hours after the administration of glucose (P less than 0.005). The levels of free fatty acids obtained during hemodialysis are higher (P less than 0.005) than those found during the other tests. The possible origin of these high fatty acid values is discussed, and the possibility that they originate from the acetate in the dialysis liquid is suggested.

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Endoscopic treatment of preneoplastic or early lesions

Elsevier eBooks (2021)

Leticia García Diéguez Ramón Vázquez Dourado Javier Castro Alvariño

Endoscopic submucosal dissection

Endoscopic mucosal resection

Polypectomy

Endoscopic treatment

10.1016/b978-0-323-90055-3.00027-2

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Artificial Intelligence Techniques for Colorectal Cancer Drug Metabolism: Ontologies and Complex Networks

Current Drug Metabolism (2010)

Marcos Martínez-Romero José M. Vázquez-Naya Juan R. Rabuñal Salvador Pita‐Fernández Ramiro Macenlle

Colorectal cancer is one of the most frequent types of cancer in the world and generates important social impact. The understanding of the specific metabolism of this disease and the transformations of the specific drugs will allow finding effective prevention, diagnosis and treatment of the colorectal cancer. All the terms that describe the drug metabolism contribute to the construction of ontology in order to help scientists to link the correlated information and to find the most useful data about this topic. The molecular components involved in this metabolism are included in complex network such as metabolic pathways in order to describe all the molecular interactions in the colorectal cancer. The graphical method of processing biological information such as graphs and complex networks leads to the numerical characterization of the colorectal cancer drug metabolic network by using invariant values named topological indices. Thus, this method can help scientists to study the most important elements in the metabolic pathways and the dynamics of the networks during mutations, denaturation or evolution for any type of disease. This review presents the last studies regarding ontology and complex networks of the colorectal cancer drug metabolism and a basic topology characterization of the drug metabolic process subontology from the Gene Ontology. Keywords: Ontology, graphs, colorectal cancer, complex network, drug metabolic pathway

10.2174/138920010791514289

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Citations (43)

Hemorheological alterations in patients with chronic renal failure. Effect of hemodialysis.

PubMed (1999)

María de la Luz Casas Martínez Amparo Vayá Javier Castro Alvariño José Luis Barberá David Ramos‐Barbón

The rheological profile of 45 patients who had kidney failure and were undergoing periodical hemodialysis was studied to ascertain whether they showed rheological alterations and if these alterations improved after hemodialysis. Our results indicate that the patients studied suffer rheological alterations with respect to the control group, specifically increased plasma fibrinogen (436 +/- 119 vs 271 +/- 43 mg/dl, p < 0.001), increased plasma viscosity (1.30 +/- 0.10 vs 1.22 +/- 0.05 mPa.s, p < 0.001), higher erythrocyte aggregability (8.3 +/- 1.2 vs 7.4 +/- 1.4, p < 0.01) and a lower hematocrit (31.2 +/- 5.9 vs 43.4 +/-3.7, p < 0.001). In contrast, erythrocyte deformability did not seem to be altered with respect to the control group. The analyses carried out immediately after hemodialysis showed that in general the rheological profile worsened during this treatment; there was a significant increase in fibrinogen and in plasma viscosity. The rheological alterations detected may play a role in the development of the atherosclerosis processes often experienced by these patients.

Plasma viscosity

Hemorheology

Erythrocyte aggregation

Chronic renal failure

Erythrocyte deformability

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Citations (24)