Farzaneh Foroughinia

Monash Health

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Afshin Borhani‐Haghighi

Shiraz University of Medical Sciences

Mehdi Dianatpour

Shiraz University of Medical Sciences

Anahid Safari

Shiraz University of Medical Sciences

Iman Jamhiri

Shiraz University of Medical Sciences

Mohammad M. Zarshenas

Shiraz University of Medical Sciences

Seyed Taghi Heydari

Shiraz University of Medical Sciences

Behnam Sabayan

Hennepin Healthcare Research Institute

Elham Haem

Shiraz University of Medical Sciences

Sathya Rao

Monash University

Parvaneh Heidari

Eastern Health

Cooperative Institutions

Shiraz University of Medical Sciences

Shiraz University

Tehran University of Medical Sciences

Namazi Hospital

Shahid Beheshti University of Medical Sciences

Shahid Beheshti University

Faghihi Hospital

Stem Cell Technology Research Center

Pharmaceutical Sciences Research Center

Iran University of Medical Sciences

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A pharmacology‐based comprehensive review on medicinal plants and phytoactive constituents possibly effective in the management of COVID‐19

Phytotherapy Research (2020)

Atefeh Jalali Farid Dabaghian Hossein Akbrialiabad Farzaneh Foroughinia Mohammad M. Zarshenas

Arisen in China, COVID‐19 (SARS‐CoV‐II) is a novel coronavirus that has been expanding fast worldwide. Till now, no definite remedial drug or vaccine has been identified for COVID‐19 treatment. Still, for a majority of infected patients, supportive therapy is the cornerstone of the management plan. To the importance of managing the COVID‐19 pandemic, this article proposed to collecting capable medicinal plants and bioactive components in both treat and supportive therapy of this novel viral infection. Clinical points in the pathogenesis, symptoms, and complications of COVID‐19 were considered. The effective plants and bioactives that may play a role in supportive therapy/management of COVID‐19 were searched, collected through the “Scopus” database and listed in three sections. Numerous medicinal plants such as Citrus Spp., Camellia sinensis , and Glycyrrhiza glabra can interference with COVID‐19 pathogenesis via inhibition of virus replication and entry to its host cells. Also, some anti‐inflammatory herbal medicine such as Andrographis paniculata , Citrus spp., and Cuminum cyminum can relieve fever and cough in COVID‐19 patients. Medicinal plants such as G. glabra , Thymus vulgaris , Allium sativum , Althea officinalis , and Panax ginseng may modulate the immune system and possess prevention and supportive therapy. However, more clinical data are required to confirm these hypotheses.

Andrographis Paniculata

10.1002/ptr.6936

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Citations (54)

Omega-3 Supplementation in the Prevention of Contrast Induced Nephropathy in Patients Undergoing Elective Percutaneous Coronary Intervention: A Randomized Placebo-Controlled Trial

Advanced Pharmaceutical Bulletin (2019)

Farzaneh Foroughinia Mahtabalsadat Mirjalili Ehsan Mirzaei Alireza Oboodi

Purpose: Contrast-induced nephropathy (CIN) is the third cause of hospital-acquired renal failure and is associated with significant morbidity and mortality. Several studies have revealed the protective role of omega-3 in prevention and treatment of some kidney injuries. This study was conducted to examine the effect of omega-3 supplementation on the markers of renal function and to evaluate its potential in the prevention of CIN in patients undergoing elective percutaneous coronary intervention (PCI). Methods: In this double-blind, randomized clinical trial, 85 eligible patients scheduled for PCI was randomly divided into omega-3 (a single 3750 mg dose of omega-3 as well as routine hydration therapy within 12 hours before PCI) or control (placebo plus routine hydration therapy) groups. Serum creatinine (SCr) and cystatin C levels were measured at baseline and 24 hours after PCI. Results: Our results indicated that post- PCI cystatin C levels were significantly decreased in the omega-3 group compared to the control group (P < 0.001). Although less upward manner was seen in the level of 24-hour creatinine in the omega-3 group, it did not reach the significance level (P = 0.008). Conclusion: The positive effect of omega-3 on cystatin C levels showed that it may have a protective role in the prevention of CIN in post-PCI patients with normal kidney function. However, to better assess this effect, it is highly recommended to design future studies with higher doses and longer duration of therapy with omega-3 plus long-term follow up.

Contrast-Induced Nephropathy

10.15171/apb.2019.036

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Evaluation of knowledge, attitude, and practice of community pharmacists toward administration of over-the-counter drugs for the treatment of diarrhea in children: A pretest-posttest survey

Journal of Research in Pharmacy Practice (2016)

Farzaneh Foroughinia Pedram Zarei

In this study, we aimed to assess knowledge, attitude, and practice of community pharmacists toward administration of over-the-counter (OTC) antidiarrheal drugs in our city pharmacies, Shiraz, Iran.In this descriptive cross-sectional study, 90 pharmacies among 128 pharmacies in our city were randomly chosen. The study was designed into two phases: A standard questionnaire to determine the level of knowledge and attitude of pharmacists and a simulated client method to evaluate practice among them. An educational pamphlet was then given to the pharmacists. One month later, knowledge, attitude, and performance of studied pharmacists were evaluated again using the same method.Our results showed that an average consultation time by female pharmacists was considerably more than male pharmacists (P < 0.001). Before intervention, only 37.8% of pharmacists performed appropriately by prescribing the proper medicine while this increased to 58.44% after intervention. The average score of pharmacists' knowledge was statistically increased (P < 0.001) and the pharmacists' performance was significantly improved (P < 0.001) after the educational intervention. In related to the attitude, pharmacists' tendency toward prescribing oral rehydration salt solutions (ORS) (P < 0.001) and their belief about the great effect of ORS on the treatment of diarrhea increased significantly after the intervention.It is concluded that training programs such as educational pamphlets and continuing educational seminars may play important roles in increasing pharmacists' knowledge and therefore improving their performance in prescribing OTC medicines.

10.4103/2279-042x.185735

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A postulated role of garlic organosulfur compounds in prevention of valproic acid hepatotoxicity

Medical Hypotheses (2007)

Behnam Sabayan Farzaneh Foroughinia Abdolhamid Chohedry

Organosulfur compounds

Valproic Acid

10.1016/j.mehy.2006.07.055

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Citations (29)

Vincristine-Induced Seizure Potentiated by Itraconazole Following RCHOP Chemotherapy for Diffuse Large B-Cell Lymphoma

Current Drug Safety (2013)

Farzaneh Foroughinia Shadi Baniasadi Sharareh Seifi Fanak Fahimi

Objectives: To report the case of a patient with diffuse large B-cell lymphoma (DLBCL) who developed vincristine (VCR)-induced seizure after R-CHOP chemotherapy. Case Summary: A 22-year-old boy with DLBCL developed generalized tonic clonic seizures following R-CHOP chemotherapy. After receiving the third cycle of chemotherapy, he developed Aspergillus pneumonia; therefore, itraconazole was started 18 days before the administration of cycle 4 of chemotherapy. Seven days after the administration of the fifth doses of vincristine, the patient reported symptoms of gastrointestinal toxicity (abdominal cramps and constipation). Subsequently, he developed three episodes of generalized tonic-clonic seizure which lasted for 2-3 minutes during one day and became unconsciousness. His serum electrolytes were normal with the exception of low serum sodium (128mEq/L). Blood glucose, blood urea nitrogen, the complete blood count, and a cerebrospinal fluid study were also normal. A computed tomography scan of the brain did not show any abnormalities. He had no previous history of convulsion. Occurrence of seizure due to central nervous system invasion of DLBCL was ruled out with a normal cerebrospinal fluid examination, computed tomography scan, and magnetic resonance imaging of the head. Therefore, the patient's neurotoxicity has been attributed to vincristine, the effects of which were likely potentiated by itraconazole therapy. Discussion: Vincristine is a naturally occurring vinca alkaloid used in various chemotherapy regimens. Neurotoxicity is a known and commonly encountered side effect of vincristine. Peripheral neuropathy is the most common form of vincristine neuropathy whereas central effects are rarer. Enhanced VCR neurotoxicities from drug interactions with several azole antifungals such as itraconazole and voriconazole have been reported. Our case represents a drug possible adverse drug effect based on the Naranjo ADR Probability Scale. Conclusion: Administration of vincristine in conjunction with azole antifungals should be with caution and after carefully considering the risks and benefits. Also, it is important to rule out other causes of seizure in these patients. Keywords: Diffuse large B-cell lymphoma (DLBCL), R-CHOP chemotherapy, seizure, itraconazole, Neurotoxicity, cerebrospinal, tomography, tonic-clonic, Aspergillus pneumonia

10.2174/1574886311207050008

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An Overview of Pharmacological and Clinical Aspects of Spirulina

Current Drug Discovery Technologies (2022)

Forough Afsari Mohammad M. Zarshenas Ramin Ansari Farzaneh Foroughinia Amir Hossein Dadbakhsh

Abstract: Spirulina or Arthrospira, a Cyanobacterium from the class Cyanophyceae, with a wide range of properties, has been applied for over 400 years. The present study aimed to review available investigations surrounding the clinical and pharmacological properties of Spirulina that have been carried out so far. Databases including Scopus, PubMed, Google Scholar, and Web of Science were searched for relevant literature using the keywords: (Spirulina), (pharmacology), and (clinical). About 130 papers that studied the pharmacological characteristics of Spirulina in animal models, as well as clinical trials, were selected from the beginning to 29 July 2021. According to this review, antioxidative, anti-inflammatory, anti-neoplastic, hypolipidemic, antiviral, immunomodulatory, antimicrobial, anti-atherogenic, anti-diabetic, and radio-protective functions are attributed to Spirulina. Moreover, Spirulina's positive influence on several organs, including hair, skin, liver, CNS, lung, and genitourinary tract, are ascribed to different components of various species of Spirulina such as Spirulina platensis, Spirulina fusiformis, and Spirulina maxima. Although so many studies have been accomplished on every aspect of Spirulina in recent years, the lack of a comprehensive investigation surrounding this microalga encouraged us to prepare this paper. Therefore, the present study could be considered an up-to-date overview of the clinical, pharmacological, and molecular aspects of Spirulina, resulting in more occupational research on this valuable organism.

Spirulina (dietary supplement)

Arthrospira

10.2174/1570163820666221129141217

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Citations (6)

Effect of pretreatment with omega-3 supplement on cardiac necrosis markers in chronic kidney disease patients undergoing elective percutaneous coronary intervention

Journal of Research in Pharmacy Practice (2017)

Maryam Foroozmehr Farzaneh Foroughinia

Objective: Studies have demonstrated the direct relation between elevation in cardiac necrosis markers and increased risk of cardiovascular complications after percutaneous coronary intervention (PCI) in chronic kidney disease (CKD) patients. In this study, we sought to evaluate the effect of omega-3 on creatine kinase-MB (CK-MB) and troponin-I in CKD patients undergoing elective PCI. Methods: Eighty CKD patients, candidate for elective PCI, were randomly assigned into two groups: Group A – receiving omega-3 (2.5 g, 12 h before PCI) plus standard treatment (n = 37) and Group B – control group, receiving only standard therapy (aspirin 325 mg and clopidogrel 600 mg loading dose and weight-adjusted intravenous heparin) (n = 43). Blood samples were collected before and 24 h after PCI for measuring CK-MB and troponin-I. The primary endpoint was considered to be postprocedural variations of CK-MB and troponin-I levels in both groups. The secondary endpoint was the percentage of pre-procedural myocardial infarction (PMI) occurrence, defined as the elevation of post-PCI troponin-I, between study groups. Findings: Both the baseline and 24-h CK-MB were significantly higher in omega-3 group. Although 24-h troponin-I increased less in omega-3-treated arm compared to the control group, no statistically significant variation was observed between the two groups. With regard to PMI occurrence, no significant difference was detected among study groups. Conclusion: Despite the beneficial but nonsignificant effects of omega-3 on decreasing post-PCI elevation of troponin-I and PMI occurrence, further investigations with bigger study population, higher doses of omega-3 and longer duration of treatment, and long-term follow-up of patients are required to better test the potential effects of omega-3 in improving clinical outcomes in CKD patients undergoing PCI.

Clinical endpoint

Creatine kinase

Creatine

10.4103/jrpp.jrpp_17_24

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Citations (6)

Evaluation of prophylactic antibiotic administration at the surgical ward of a major referral hospital, Islamic Republic of Iran

Eastern Mediterranean Health Journal (2011)

Ghazal Vessal Soha Namazi Mohammad Ali Davarpanah Farzaneh Foroughinia

We evaluated the appropriateness of antibiotic prophylaxis administered before surgery at a major referral hospital in Shiraz, against the American Society of Hospital Pharmacists (ASHP) guidelines. Data on surgical procedure, choice of antibiotic and administration were gathered for all surgeries performed on hospitalized patients during 15 days in March 2010. Of 155 patients included in the analysis, 98% received prophylactic antibiotic before surgery; according to ASHP guidelines, prophylaxis was needed in only 106 (68.4%). Of these 106, only 8 patients received the correct antibiotic regimen. The commonest regimens administered were cefazolin + gentamicin (47.6%), cefazolin (20.5%) and cefuroxime (8.5%). Antibiotic prophylaxis was continued in 83% of cases, while this was necessary in only 37%. In only 1 surgical procedure were all evaluated parameters correct.

Cefazolin

Cefuroxime

10.26719/2011.17.8.663

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Citations (40)

An evaluation of classification algorithms for prediction of drug interactions: Identification of the best algorithm

International Journal of Pharmaceutical Investigation (2018)

Nasrin Shokrpour Rita Rezaee Reza Akbari Milad Nasiri Farzaneh Foroughinia

Introduction: One of the main causes of medical errors is drug interaction which occurs when a drug decreases or increases the effect of another drug. Drug interactions occur as a result of changes in pharmacodynamics, pharmacokinetics, or a combination of both. Due to the problems caused by these errors and lack of an efficient system of automatic diagnosis of drug interactions, and also since a large amount of these interactions can be prevented, we aimed to search for drug interactions in the medical texts and also classify and identify the best algorithm. Methods: A two‑stage classification was used to solve the problem of unbalanced data dispersion in drug interaction classes. A subset of the most suitable features was identified for classification. In the first step of designing a binary classification, pairs of drugs which interact with each other and those which do not be separated. Then, we classified the pairs of drug interactions in one of the following four classes: effect, advice, mechanism, and int. In this study, different algorithms were used in both types of classifications, based on the type of data and expert opinion. To validate the first‑stage model, we considered 90% of the data as training data and the rest were considered as the test data. To validate the second‑stage model, we used the difference verification method. Weka data analysis software was also used for designing the model; then, the classification was made. Results: The results showed that the most appropriate features were mutual information (obtaining a score of 1000) and parts of speech. The efficiency of J48 algorithm in the stage of separating the drugs with and without interaction (F‑measure = 0.914) and also in the multiclass stage of the bagging algorithm (F‑measure = 0.915) was the highest among other algorithms. ZeroR algorithm required the shortest time to build the model (less than half a second) in both stages. Conclusion: According to the results of J48 algorithms and random forest, it can be concluded that decision tree is the most appropriate approach in the extraction and automatic classification of drug interactions, using the features derived from the text to be applied in clinical decision support system.

Identification

Statistical classification

Binary classification

10.4103/jphi.jphi_19_18

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Citations (5)

Drug utilization evaluation of meropenem: an important broad-spectrum antibiotic for the treatment of serious bacterial infections in hospitalized patients

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

Farzaneh Foroughinia Seyed Mohammadreza Hashemian Fanak Fahimi

Increasing trend in the development of antibiotic resistance is one the major concerns of health care systems throughout the world. Several factors are responsible of the emergence of this problem of which frequent inappropriate uses of antimicrobial agents plays an important role. Therefore, in the study we aimed to assess the appropriateness of the usage of meropenem, a broad-spectrum antibiotic, in a teaching affiliated hospital.This study is an observational prospective research on drug utilization. All patients admitted to Masih Daneshvari hospital that had received meropenem during Jun to July 2011 were enrolled in the study. To evaluate the appropriate use of meropenem, an institutional standard guideline was designed by pharmacy and therapeutic committee using evidence-based guidelines. Prescriptions were considered appropriate if they were compliant with the guideline. The total number of meropenem vials used during this period was 2153 vials. Most prescriptions started empirically (85.9%). Of these, 16.9% of prescriptions continued according to lab results whereas 69% of meropenem courses remained empirical. Our results showed that meropenem was started appropriately in 64.8% of patients whereas just 74.3% of patients received the drug for an adequate duration.In conclusion, our study and several other surveys detected various areas of inappropriate use of broad-spectrum antiobiotics such as meropenem. With regard to the important role of these drugs in the treatment of serious nosocomial infections, a combination of both restrictive and educational measures appears to be necessary to improve rational antibiotic usage as well as to decrease in the frequency of antibiotic resistant.

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