Paolo Mantegazza

Research Field

Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists

Naunyn-Schmiedeberg s Archives of Pharmacology (1986)

F. Zambotti N. Zonta R. Tammiso P. Ferrario Benjamin Hafner

10.1007/bf00569658

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Citations (21)

Perinatal morphine treatment inhibits pruning effect and regeneration of serotoninergic pathways following neonatal 5,7‐HT lesions

Journal of Neuroscience Research (1993)

Alfred Gorio Anna Maria Di Giulio Elena Germani Caterina Bendotti A Bertelli

Lesion of the serotoninergic system in neonate rats is an ideal model for assessing the activity of chemical substances capable of affecting neuronal plasticity and regeneration (Jonsson et al., Dev Brain Res 16: 171-180, 1984). Treatment of newborn rats within 6 hr from birth with the selective neurotoxin 5,7-dihydroxytryptamine causes degeneration of the most distal serotoninergic axons. In our experimental conditions we have observed that after such neurotoxic treatment there is spinal cord denervation, which is particularly remarkable in the lumbar segment. This degenerative event is followed by gradual regeneration of the lesioned axons, with good reinnervation of the entire cord within 8 weeks. The degeneration-regeneration process is correlated with a transient hyperinnervation of the pons-medulla and hypothalamus by the short collaterals (pruning effect), as evidenced by increased serotonin content. Perinatal morphine exposure markedly impairs serotonin regeneration in the spinal cord. In addition, opiate treated rats are more susceptible to lesions, as shown by the neurotoxin induced denervation of the cortex, pons-medulla, and hypothalamus, which does not occur in lesioned controls. Therefore, our observations suggest that perinatal exposure to morphine affects the plasticity and regeneration of the developing serotoninergic system by increasing its susceptibility to neurotoxic lesions and reducing its regenerative capacity.

Pruning

10.1002/jnr.490340411

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Citations (13)

Pulse-width equivalent to pulse-amplitude discrete control of linearsystems

Journal of Guidance Control and Dynamics (1992)

F. Bernelli Zazzera Paolo Mantegazza

This paper presents a method to translate pulse-amplitude modulated discrete controls, for which many design algorithms exist, into pulse-width modulated controls extensively used in aerospace applications. Assuming that a discrete control law is available for a linear time-invariant multivariable system, the conditions for an approximate equivalent pulse-width application of the inputs are developed. The approximation is based on pulse, i.e., amplitude • duration, intensity equivalence, and on the evaluation of an optimum firing delay that maintains, independently from the control and external input, the dynamic performances of the system, including stability. A simple numerical example on a second-order system points out the benefits and drawbacks of the method, which is then applied to a typical complex aerospace design problem, i.e., shape and pointing control of a space antenna.

10.2514/3.20858

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Citations (34)

Professor Paul Mantegazza's Gesammelte Schriften : (Physiologie der Liebe, Hygiene der Liebe, Physiologie des Genusses)

Paolo Mantegazza

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Effect of etoperidone on the depletion of brain 5-hydroxytryptamine and catecholamines induced respectively by p-chloromethamphetamine and 6-hydroxydopamine in rats

Pharmacological Research Communications (1979)

Michele O. Carruba Marco Parenti Sante Ricciardi Giovanni B. Picotti Paolo Mantegazza

Hydroxydopamine