Derek C. Waggoner

Urine drug testing (UDT) is a standard practice used for monitoring controlled and illicit substances in ambulatory care patients. Point-of-care (POC) UDTs are useful tools that allow for drug identification within minutes, providing rapid and objective diagnostic assistance for clinicians. The objective of this study was to evaluate the performance characteristics of 3 different POC UDT devices compared to reference methods.A total of 106 residual urine specimens were collected to evaluate the 3 POC UDT devices: the Profile®-V MEDTOX Scan® drugs of abuse test, Quidel Triage® TOX Drug screen, and Quidel Triage Rapid OXY-BUP-MDMA panel. Device performance was assessed by their ability to identify drug classes/compounds compared to manufacturer and reference method (mass spectrometry) cutoffs.The results from quantitative mass spectrometry showed that 77% (84/106) of the samples were positive for one or more drugs. Each device had variable performance across each drug class. Overall, the specificity of the Profile-V MEDTOX Scan test was 90.1%, while the Quidel Triage TOX Drug Screen and Rapid OXY-BUP-MDMA devices had specificities of 89.0% and 50.0% using their respective manufacturer-stated cutoffs. Overall sensitivity was determined to be 98.6%, 97.0%, and 100% for the Profile-V MEDTOX Scan, Quidel Triage TOX Drug Screen, and Rapid OXY-BUP-MDMA, respectively.Of the 3 POC UDT devices evaluated, the Profile-V MEDTOX Scan demonstrated the best overall sensitivity and specificity compared to reference methods. False positive and negative results are possible with UDTs, ultimately the best device may depend on patient population and drugs of interest.

Triage

Point of care

Drug Detection

Point-of-Care Testing

MDMA

Drugs of abuse

Cut-point

10.1093/jalm/jfab095

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Citations (2)

Thermally assisted methylation of glycerol by tetramethylammonium hydroxide thermochemolysis

Journal of Analytical and Applied Pyrolysis (2016)

Derek C. Waggoner Patrick G. Hatcher

Tetramethylammonium hydroxide

Tetramethylammonium

Ammonium hydroxide

10.1016/j.jaap.2016.09.014

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The molecular composition of humic acids, as reflected by FTICR-MS, varies systematically in terms of the total C storage of the corresponding soils

M. A. Jiménez González Derek C. Waggoner Ana María Álvarez Francisco Javier González-Vila Patrick G. Hatcher

2 paginas.-- 2 figuras.-- 4 referencias.-- Comunicacion oral preesentada en el 19th International Conference of Humic Substances and their Contribution to the Climate Change Mitigation 16–21 September 2018 Albena Resort, Bulgaria

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Survival of Acetate in Biodegraded Stream Water DOM: New Insights Based on NMR Spectroscopy

AGUFM (2017)

Stephanie D. Whitty Derek C. Waggoner Jennifer C. Bowen Rose M. Cory L. A. Kaplan

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Molecular evidence for the export of terrigenous organic matter to the north Gulf of Mexico by solid-state 13C NMR and Fourier transform ion cyclotron resonance mass spectrometry of humic acids

Geochimica et Cosmochimica Acta (2021)

Sarah A. Ware Blaine E. Hartman Derek C. Waggoner D. Vaughn Thomas S. Bianchi