The continent ileostomy (CI) was first described in 1969 as an important advancement in the surgical treatment of patients with ulcerative colitis, providing an option for fecal continence to patients who would otherwise require a conventional ileostomy. The CI enjoyed a brief period of relative popularity during the 1970s before being displaced by today's gold standard for the surgical treatment of ulcerative colitis, the restorative proctocolectomy (ileal pouch-anal anastomosis [IPAA]). Although the CI is only rarely performed today, it still has a role to play in the treatment of patients with inflammatory bowel disease who have failed medical treatment. Current indications are patients with failed IPAAs who are not candidates for redo-IPAA, patients who require total proctocolectomy but cannot be reconstructed with IPAA, and patients with an existing conventional ileostomy that is adversely affecting their quality of life. CI, however, is a complex procedure that carries significant risk of both postoperative complications and the need for reoperation over the long term due to slippage of the nipple valve. Patients being considered for this procedure should undergo extensive preoperative counseling and must have a thorough understanding of the associated risks and a realistic vision of anticipated benefits. In well-selected and properly motivated patients, however, CI can be durable in the majority with long-term pouch survival rates approaching 80%. Published data suggest that these patients enjoy greater quality of life than their counterparts with a conventional ileostomy and that 95% would choose to undergo the procedure again or recommend it to another.

Proctocolectomy

Ileostomy

Toxic megacolon

Pouch

10.1097/mib.0000000000000160

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Citations (43)

Imprint

Breast Care (2012)

Christoph Thomssen Norbert Marschner Michael Untch Thomas Decker Susanna Hegewisch‐Becker

10.1159/000337706

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Effects Of Darbepoetin Alpha on Brain Tissue Oxidative Stress in Experimental Ethanol Administration

Balkan Medical Journal (2009)

Pınar Seymen Erman Aytaç Feray Bölükbaşı Fatih Demir Habibe Genç

Objectives: The hyperglycosylated erythropoietin analogue darbepoetin alpha (aalpha;) has longer half-life and higher in vivo activity. There is no data about the effects of darbepoetin-aalpha; on ethanol-induced oxidative stress. In this study, we investigated the effects of darbepoetin-aalpha; on brain tissue oxidant/antioxidant status and nitric oxide levels in experimental ethanol administration. Patients and Methods: Forty-four adult male Wistar albino rats were randomly divided into groups: salinetreated group (S) (n=10), saline and darbepoetintreated group (D) (10 amu;g/kg) (n=10), experimental ethanol-administered [2.5 g/kg (2.6 ml/kg) twice at 2-hr intervals] group (E) (n=12), ethanol-administered and darbepoetin-treated group (ED) (n=12). Results: Malondialdehyde (MDA) levels of ED group were significantly lower than E group (palt;0.05). Glutathione (GSH) levels of ED group were significantly higher than E group (palt;0.001). NO levels of ED group were significantly lower than E group (palt;0.001). Conclusion: We have observed that darbepoetin-aalpha; decreases oxidants and increases antioxidants against ethanol-induced oxidative stress. Darbepoetin-aalpha; is protective in ethanol-induced organism via its antioxidant activity. Turkish Baslik: Deneysel Etanol Uygulamasinda Darbepoetin Alfanin Beyin Dokusu Oksidatif Stresi Uzerine Etkileri Anahtar Kelimeler: Darbepoetin alfa; oksidatif stres; NO; lipit peroksidasyonu Amac: Eritropoetin analogu darbepoetin alfa, yari omru uzun ve in vivo yuksek aktiviteye sahip bir molekuldur. Alkolun etkili oldugu organizmada darbepoetinin etkisi henuz ortaya konulmamistir. Bu calismada, deneysel etanol uygulamasinda darbepoetin alfanin beyin dokusu oksidan/antioksidan denge ve nitrik oksit seviyesi uzerine etkilerini arastirdik. Hastalar ve Yontemler: Kirk dort eriskin erkek Wistar Albino sican raslantisal olarak gruplara ayrildi: %0.9 NaCl uygulanan grup (S) (n=10), %0.9 NaCl ve darbepoetin verilen grup (D) (10 amu;g /kg) (n=10), deneysel etanol uygulamasi yapilan [2.5 g/kg (2.6 ml/kg) 2-saatlik araliklar ile iki defa] grup (E) (n=12), etanol uygulanan ve darbepoetin verilen grup (ED) (n=12). Bulgular: ED grubu malondialdehit (MDA) degerleri E grubundan anlamli olarak dusuktu (palt;0.05). ED grubu glutatyon (GSH) degeri E grubundan anlamli olarak yuksekti (palt;0.001). ED grubu NO degerleri E grubundan anlamli olarak dusuktu (palt;0.001). Sonuc: Deneysel etanol uygulamasi modelinde darbepoetin alfanin oksidanlari dusurdugunu, antioksidanlari ise artirdigini gozlemledik. Darbepoetin alfa antioksidan aktivitesi ile alkol uygulanan organizmada koruyucu etkilere sahiptir.

Darbepoetin alfa

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Impact of Increased Body Mass Index on Laparoscopic Surgery for Rectal Cancer

European Surgical Research (2011)

Tayfun Karahasanoğlu İsmail Hamzaoğlu Bilgi Baca Erman Aytaç Ebru Kirbiyik

Laparoscopy was initially considered to be a risky procedure for rectal cancer patients, especially patients with an increased body weight. The literature is scarce regarding the effects of obesity on laparoscopic rectal surgery. The aim of the current study was to analyze the effect of an increased body mass index (BMI) on outcome of laparoscopic surgery for rectal cancer.Patients who underwent laparoscopic rectal resection were allocated to one of three groups according to their BMI: normal weight (BMI < 25), overweight (25 ≤ BMI < 30) and obese (BMI ≥ 30). These three groups were compared with each other in terms of patient demographics, postoperative hospital stay, postoperative complications and histopathological data.There were 100 patients operated on for rectal cancer. The median BMI of the patients was 27 (range 18.5-40) kg/m(2), and 43, 43 and 14 patients were classified as normal weight, overweight and obese, respectively. The conversion rate was 4.7% in the overweight group and 0% in the other groups. The proportion of complications and oncological outcomes between the groups showed no significant difference (p > 0.05).Apparently, increased BMI is not a contraindication for laparoscopic rectal surgery.

Contraindication

10.1159/000321360

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Citations (34)

Iloprost Pretreatment Before Unilateral Nephrectomy: An Experimental Study in Rats

Asian Journal of Surgery (2008)

Erman Aytaç Pınar Seymen Göksel Dikmen Hafize Uzun Hakkı Oktay Seymen

Iloprost

Malondialdehyde

10.1016/s1015-9584(08)60061-5

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Citations (2)

Supplementary Material for: Excision of Nonpalpable Breast Cancer with Indocyanine Green Fluorescence-Guided Occult Lesion Localization (IFOLL)

Figshare (2012)

Fatih Aydoğan Volkan Özben Erman Aytaç Hatice Bal Yılmaz Ali Çerçel

Background: Currently employed techniques for the localization of nonpalpable breast lesions suffer from various limitations. In this paper, we report on 2 patients in order to introduce an alternative technique, indocyanine green fluorescence-guided occult lesion localization (IFOLL), and determine its applicability for the surgical removal of this type of breast lesions. Case Reports: Preoperatively, one of the patients had a needle biopsyproven diagnosis of breast cancer, and the other one had suspicious findings for malignancy. Lesion localization was performed within 1 h before surgery under ultrasonography control by injecting 2 ml and 0.2 ml of indocyanine green into the lesion and its subcutaneous tissue projection, respectively. During surgery, the site of skin incision and the resection margins were identified by observing the area of indocyanine-derived fluorescence under the guidance of a near-infrared-sensitive camera. In both cases, the breast lesion was correctly localized, and the area of fluorescence corresponded well to the site of the lesions. Subsequent surgical excision was successful with no complications. On histopathologic examination, the surgical margins were found to be clear. Conclusion: IFOLL seems to be a technically applicable and clinically acceptable procedure for the removal of nonpalpable breast cancer.

Occult

Indocyanine Green

10.6084/m9.figshare.5123305

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Combined laparoscopic–robotic approach in complex re‐operative colorectal surgery – a video vignette

Colorectal Disease (2017)

İsmail Ahmet Bilgin Erman Aytaç Ilknur Erenler Bilgi Baca İsmail Hamzaoğlu

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Vignette

Colorectal Surgery

10.1111/codi.13687

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Lipid Peroxidation and Visual Evoked Potentials of Rats Exposed to Cigarette Smoke in Hypobaric, Hyperbaric and Normobaric Conditions

The FASEB Journal (2006)

Nihal Koç Erman Aytaç İlhan Tan Pınar Atukeren Oya Yeter

Visual evoked potentials

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