An analysis of 98 cases of acute postoperative pancreatitis has been made. The development of acute postoperative pancreatitis was found to be associated with the appearance of fat tissue necrosis under the influence of the activated enzymes of the pancreas The involvement of exocrinous and endocrinous structures of the pancreas into the inflammatory process was developing with progressing of the disease. Postoperative purulent pancreatitis was caused by the secondary infection of the pancreas and the pancreatic fat tissue.