Lung‐Chang Lin

Hospital Tuanku Ja’afar

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Rei‐Cheng Yang

Changhua Christian Hospital

Chen‐Sen Ouyang

National Kaohsiung University of Science and Technology

Ching‐Tai Chiang

National Pingtung University

Rong‐Ching Wu

Henan University of Technology

Hui‐Chuan Wu

Kaohsiung Medical University

Yi-Hung Chiu

I-Shou University

Hin‐Kiu Mok

National Sun Yat-sen University

Ruey-Chang Wei

National Sun Yat-sen University

Wei‐Te Lee

Kaohsiung Municipal Hsiao-Kang Hospital

Chin-Lin Tsai

Kaohsiung Medical University

Cooperative Institutions

Kaohsiung Medical University

National Yang Ming Chiao Tung University

Kaohsiung Medical University Chung-Ho Memorial Hospital

National Taiwan University

National Taiwan University Hospital

Taipei Medical University

Taipei Veterans General Hospital

National Defense Medical Center

National Sun Yat-sen University

China Medical University

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Neuropeptide Y Gene Polymorphism and Plasma Neuropeptide Y Level in Febrile Seizure Patients in Taiwan

The Kaohsiung Journal of Medical Sciences (2007)

Lung‐Chang Lin Hung‐Shun Lin Rei‐Cheng Yang

Neuropeptide Y (NPY) has been shown to depress the hyperexcitability of neurons. In the present study, we investigated the association between the nucleotide (nt) 5671 C/T polymorphism of the NPY gene and the plasma NPY level in patients with febrile seizures (FS). Fifty‐six patients with FS and 55 control subjects were enrolled. Genotype and allele frequencies were compared. The frequencies of genotypes TT, TC and CC for the NPY gene nt 5671 C/T polymorphism were 21.4%, 28.6% and 50.0%, respectively, in patients with FS, and 14.6%, 40.0% and 45.4%, respectively, in control subjects. The frequencies of alleles T and C were 35.7% and 64.3%, respectively, in patients with FS, while those in the control group were 34.5% and 65.5%, respectively. We found no significant relationship between the NPY gene nt 5671 C/T polymorphism and FS. The plasma NPY concentrations of the FS group, the age‐matched non‐FS group, and subjects aged > 6 years in the non‐FS group were 48.23±32.49, 55.36±23.12, and 70.10±60.31 pg/mL, respectively. These results indicate no statistical difference in plasma NPY concentration between FS patients and the non‐FS group. However, plasma NPY concentration was found to increase significantly with age.

Febrile seizure

Gene polymorphism

10.1016/s1607-551x(08)70003-2

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Citations (7)

The neuropsychological outcome of pediatric patients with refractory epilepsy treated with VNS — A 24-month follow-up in Taiwan

Epilepsy & Behavior (2016)

Jeng-Dau Tsai Ying‐Chao Chang Lung‐Chang Lin Kun‐Long Hung

Refractory (planetary science)

Pediatric epilepsy

10.1016/j.yebeh.2015.12.030

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Citations (22)

Determination of Antiepileptic Drugs Withdrawal Through EEG Hjorth Parameter Analysis

International Journal of Neural Systems (2020)

Chen‐Sen Ouyang Rei‐Cheng Yang Rong‐Ching Wu Ching‐Tai Chiang Lung‐Chang Lin

The decision to continue or to stop antiepileptic drug (AED) treatment in patients with prolonged seizure remission is a critical issue. Previous studies have used certain risk factors or electroencephalogram (EEG) findings to predict seizure recurrence after the withdrawal of AEDs. However, validated biomarkers to guide the withdrawal of AEDs are lacking. In this study, we used quantitative EEG analysis to establish a method for predicting seizure recurrence after the withdrawal of AEDs. A total of 34 patients with epilepsy were divided into two groups, 17 patients in the recurrence group and the other 17 patients in the nonrecurrence group. All patients were seizure free for at least two years. Before AED withdrawal, an EEG was performed for each patient that showed no epileptiform discharges. These EEG recordings were classified using Hjorth parameter-based EEG features. We found that the Hjorth complexity values were higher in patients in the recurrence group than in the nonrecurrence group. The extreme gradient boosting classification method achieved the highest performance in terms of accuracy, area under the curve, sensitivity, and specificity (84.76%, 88.77%, 89.67%, and 80.47%, respectively). Our proposed method is a promising tool to help physicians determine AED withdrawal for seizure-free patients.

Antiepileptic drug

Drug withdrawal

10.1142/s0129065720500367

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Citations (17)

Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy

Epilepsy & Behavior (2011)

Lung‐Chang Lin Wei‐Te Lee Chien-Hua Wang Hsiu‐Lin Chen Hui‐Chuan Wu

MOZART

Refractory (planetary science)

10.1016/j.yebeh.2010.12.044

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Citations (63)

Early evaluation of the therapeutic effectiveness in children with epilepsy by quantitative EEG: A model of Mozart K.448 listening—a preliminary study

Epilepsy Research (2014)

Lung‐Chang Lin Chen‐Sen Ouyang Ching‐Tai Chiang Hui‐Chuan Wu Rei‐Cheng Yang

Vagus Nerve Stimulation

Music Therapy

10.1016/j.eplepsyres.2014.06.020

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Citations (15)

Alopecia and colon ulcers following azathioprine use in a patient with myasthenia gravis: A case report

Medicine (2022)

Wan‐Yi Hsu Pei‐Chin Lin Yi‐Ching Liu Lung‐Chang Lin

Rationale: Azathioprine is a purine analog (PA) used to treat myasthenia gravis (MG). However, some patients are sensitive to azathioprine and develop severe side effects, such as leukopenia, alopecia, and diarrhea soon after using the medication. Pharmacogenetics plays a crucial role in such intolerance. Patient concerns: A 16-year-old woman with MG developed hair loss, pancytopenia, bloody diarrhea, and fever shortly after azathioprine treatment. Diagnosis: Pharmacogenetic analysis revealed compound heterozygosity of the nudix hydrolase 15 ( NUDT15 ) gene, which led to suppressed NUDT15 function. Colonoscopy revealed large ulcers with polypoid lesions in the terminal ileum, cecum, ascending colon, and rectum. These are the characteristics of inflammatory bowel disease (IBD). Interventions: Sanger sequencing of NUDT15 gene and colonoscopy for bloody stool evaluation. Outcomes: The patient recovered completely from this acute episode after discontinuation of azathioprine treatment. Her hemogram turned back to normal range. There was also no blood in stool during follow-up. Lessons: Pharmacogenetic effects should be considered when prescribing PA medication. The possibility of secondary or concomitant autoimmune diseases must always be considered in patients with MG.

10.1097/md.0000000000029986

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Oxcarbazepine誘發史帝文-強森症候群-一個案報告

林龍昌賴彬卿楊曉芳楊瑞成 Lung‐Chang Lin

Oxcarbazepine

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Salmonella/rotavirus coinfection in hospitalized children

The Kaohsiung Journal of Medical Sciences (2012)

Wei‐Te Lee Pei‐Chen Lin Lung‐Chang Lin Hsiu‐Lin Chen Rei‐Cheng Yang

Abstract This study's aim was to analyze the characteristics and severity of acute gastroenteritis related to infection with rotavirus (group R), nontyphoid Salmonella (NTS; group S), and infection with both rotavirus and Salmonella (group B) in children in southern Taiwan in order to improve diagnosis and expedite appropriate management. The medical records of children admitted between October 2002 to September 2008 for acute gastroenteritis related to rotavirus, NTS, or coinfection were collected and analyzed.Among 2040 reviewed medical records, 40 patients were infected with both pathogens, while 501 cases were infected with rotavirus alone and 189 were infected with NTS alone. There were no significant differences between the three groups in terms of age at admission or sex. The age distribution of the reviewed cases revealed that children between the ages of 12–24 months comprised the largest proportion of cases in each group. Higher concentrations of fecal leukocytes and fecal pus cells and longer hospitalizations were observed in group B in comparison with groups S and R ( p < 0.05). Clinical severity was significantly higher in groups B and S than group R ( p < 0.05). A proportional association was found between the monthly case number of rotavirus infections and the mean monthly temperature difference in southern Taiwan ( r = 0.9248; p < 0.0001). In summary, concomitant rotavirus infection with NTS infection did not affect the clinical manifestations of the reviewed patients. Rotavirus infection was less severe in most clinical manifestations, but vomiting was more severe in rotavirus‐infected patients. Positive fecal leukocytes and positive fecal pus cells were more frequent during coinfection. There was a strong positive relationship between the incidence of rotavirus gastroenteritis and the mean monthly temperature difference.

Medical record

Concomitant

Group A

Acute gastroenteritis

10.1016/j.kjms.2012.04.025

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Citations (15)

Hyperammonemia and positive allopurinol test in hyperinsulinism–hyperammonemia syndrome: Taiwanese case report

Pediatrics International (2009)

Lung‐Chang Lin Wuh‐Liang Hwu Rei‐Cheng Yang

General hospital

10.1111/j.1442-200x.2009.02812.x