Augusto Feynman Dias Nobre

Universidade Federal do Ceará

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Anderson da Cunha Costa

Universidade Federal do Ceará

Mirele Rodrigues Fernandes

Universidade Federal do Ceará

Raimunda Sâmia Nogueira Brilhante

Universidade Federal do Ceará

Raimunda Sâmia Nogueira Brilhante

Universidade Federal do Ceará

Marcos Fábio Gadelha Rocha

Universidade Estadual do Ceará

Anderson Messias Rodrigues

Universidade Federal de São Paulo

Rosemeyre Souza Freire

Universidade Federal do Ceará

Maria Gleiciane Rocha

Universidade Federal do Ceará

Jacó Ricarte Lima de Mesquita

Hospital de São José

Zoilo Pires dè Camargo

Universidade Federal de São Paulo

Cooperative Institutions

Universidade Federal do Ceará

Universidade de Fortaleza

Universidade Estadual do Ceará

Instituto Federal de Educação, Ciência e Tecnologia do Ceará

Secretaria da Saúde

Unichristus

Children's Specialized Hospital

Universidade de São Paulo

KTH Royal Institute of Technology

AlbaNova

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

In vitro study of essential oils encapsulated in chitosan microparticles against Histoplasma capsulatum and their pathogenicity in Caenorhabditis elegans

Biofouling (2025)

Anderson da Cunha Costa Mirele Rodrigues Fernandes Augusto Feynman Dias Nobre Maria Gleiciane Rocha Jacó Ricarte Lima de Mesquita

Histoplasmosis, caused by Histoplasma capsulatum, poses risks for immunocompromised individuals. With limited therapeutic options, this study explores microparticles as antimicrobial delivery systems for Cymbopogon flexuosus and Pelargonium graveolens essential oils against H. capsulatum. The broth microdilution assay showed MICs of 32 to 128 µg/mL in filamentous phase and 8 to 64 µg/mL in yeast phase. Combining microparticles with antifungal drugs demonstrated synergistic effects in both filamentous and yeast-like forms with amphotericin B or itraconazole. Chitosan microparticles reduced H. capsulatum biofilm biomass and metabolic activity by about 60% at 512 µg/mL. In vivo evaluation with Caenorhabditis elegans showed H. capsulatum caused over 90% mortality. These findings highlight the potential use of chitosan microparticles as a delivery system for essential oils against H. capsulatum, especially in combination with other compounds.

Histoplasma

10.1080/08927014.2025.2453184

Cite

Citations (0)

Antifungal Activity of Chitosan against Histoplasma capsulatum in Planktonic and Biofilm Forms: A Therapeutic Strategy in the Future?

Journal of Fungi (2023)

Raimunda Sâmia Nogueira Brilhante Anderson da Cunha Costa Jacó Ricarte Lima de Mesquita Géssica dos Santos Araújo Rosemeyre Souza Freire

Histoplasmosis is a respiratory disease caused by Histoplasma capsulatum, a dimorphic fungus, with high mortality and morbidity rates, especially in immunocompromised patients. Considering the small existing therapeutic arsenal, new treatment approaches are still required. Chitosan, a linear polysaccharide obtained from partial chitin deacetylation, has anti-inflammatory, antimicrobial, biocompatibility, biodegradability, and non-toxicity properties. Chitosan with different deacetylation degrees and molecular weights has been explored as a potential agent against fungal pathogens. In this study, the chitosan antifungal activity against H. capsulatum was evaluated using the broth microdilution assay, obtaining minimum inhibitory concentrations (MIC) ranging from 32 to 128 µg/mL in the filamentous phase and 8 to 64 µg/mL in the yeast phase. Chitosan combined with classical antifungal drugs showed a synergic effect, reducing chitosan’s MICs by 32 times, demonstrating that there were no antagonistic interactions relating to any of the strains tested. A synergism between chitosan and amphotericin B or itraconazole was detected in the yeast-like form for all strains tested. For H. capsulatum biofilms, chitosan reduced biomass and metabolic activity by about 40% at 512 µg/mL. In conclusion, studying chitosan as a therapeutic strategy against Histoplasma capsulatum is promising, mainly considering its numerous possible applications, including its combination with other compounds.

Histoplasma

Broth microdilution

10.3390/jof9121201

Cite

Citations (7)

Exogenous fungal quorum sensing molecules inhibit planktonic cell growth and modulate filamentation and biofilm formation in the Sporothrix schenckii complex

Biofouling (2020)

Raimunda Sâmia Nogueira Brilhante Vandbergue Santos Pereira Augusto Feynman Dias Nobre Jonathas Sales de Oliveira Mirele Rodrigues Fernandes

This study investigated the effect of the quorum sensing molecules (QSMs) farnesol, 2-phenylehtanol, tyrosol and tryptophol against planktonic cells, filamentation and biofilms of Sporothrix spp. The antifungal activity of QSMs was evaluated by broth microdilution. QSMs showed MICs in the ranges of 0.01-1 µM (farnesol), 1-8 mM (2-phenylehtanol and tyrosol), and >16 mM (tryptophol). Filamentous biofilm formation was inhibited by farnesol and 2-phenylehtanol and stimulated by tyrosol. Yeast biofilm formation was inhibited by 2-phenylehtanol and tyrosol. Tryptophol did not affect Sporothrix biofilm formation. QSMs showed MICs against mature biofilms of 8-32 µM (farnesol), 8-32 mM (2-phenylehtanol) and 64-128 mM (tyrosol). In conclusion, farnesol, 2-phenylethanol and tyrosol have antifungal activity against planktonic and sessile cells and modulate filamentation and biofilm formation in Sporothrix spp.

Tyrosol

Filamentation

Sporothrix schenckii

Sporothrix

10.1080/08927014.2020.1828373

Cite

Citations (9)

Monographs on the Fishes of the Iberian Peninsula and Madeira

Copeia (1937)

George S. Myers F. De Buen Luis Lozano Rey Augusto Feynman Dias Nobre Adolfo Cesar de Noronha

Peninsula

10.2307/1436281

Cite

Citations (0)

Effect of proton pump inhibitors on susceptibility and melanogenesis of Sporothrix species

Journal of Medical Microbiology (2024)

Augusto Feynman Dias Nobre Alanna Mayara Soares de Sousa Anderson da Cunha Costa Mirele Rodrigues Fernandes Rajender Kumar

Introduction. Sporotrichosis is a subcutaneous infection caused by dimorphic Sporothrix species embedded in the clinical clade. Fungi have virulence factors, such as biofilm and melanin production, which contribute to their survival and are related to the increase in the number of cases of therapeutic failure, making it necessary to search for new options. Gap statement. Proton pump inhibitors (PPIs) have already been shown to inhibit the growth and melanogenesis of other fungi. Aim. Therefore, this study aimed to evaluate the effect of the PPIs omeprazole (OMP), rabeprazole (RBP), esomeprazole, pantoprazole and lansoprazole on the susceptibility and melanogenesis of Sporothrix species, and their interactions with itraconazole, terbinafine and amphotericin B. Methodology. The antifungal activity of PPIs was evaluated using the microdilution method, and the combination of PPIs with itraconazole, terbinafine and amphotericin B was assessed using the checkerboard method. The assessment of melanogenesis inhibition was assessed using grey scale. Results. The OMP and RBP showed significant MIC results ranging from 32 to 256 µg ml −1 and 32 to 128 µg ml −1 , respectively. Biofilms were sensitive, with a significant reduction ( P <0.05) in metabolic activity of 52% for OMP and 50% for RBP at a concentration of 512 µg ml −1 and of biomass by 53% for OMP and 51% for RBP at concentrations of 512 µg ml −1 . As for the inhibition of melanogenesis, only OMP showed inhibition, with a 54% reduction. Conclusion. It concludes that the PPIs OMP and RBP have antifungal activity in vitro against planktonic cells and biofilms of Sporothrix species and that, in addition, OMP can inhibit the melanization process in Sporothrix species.

Terbinafine

10.1099/jmm.0.001870

Cite

Citations (0)

OBSERVATIONS SUR LE COMPORTEMENT ALIMENTAIRE DE LA POPULATION DE TRUITES COMMUNES, SALMO TRUTTA L., DANS LA RIVIÈRE ESTORÂOS, PORTUGAL

Augusto Feynman Dias Nobre Praça Gomes Teixeira Saint-Pée-Sur-Ni Velle

Source

Cite

Citations (0)

Influence of Agaricus blazei Murill polysaccharides on synthesis, stabilization, acute toxicity and antifungal activity of copper (II) oxide nanoparticles

BioMetals (2024)

Álvaro Henrique Candido de Souza Matheus da Silva Campelo Gabriel de Sousa Mesquita Augusto Feynman Dias Nobre Vitória Maria de Freitas Franco

Agaricus

10.1007/s10534-024-00650-w

Cite

Citations (0)

The Political Structure of the Federal Brazilian Republic Under the Constitution of 1988

Augusto Feynman Dias Nobre

Political structure

Federal republic

Cite

Citations (2)

Mollusques de l’expedition scientifique de Francisco Newton à Timor

Augusto Feynman Dias Nobre

Source

Cite

Citations (1)

RESIDÊNCIA PEDAGÓGICA EM BIOLOGIA: RELAÇÃO ENTRE ASPECTOS TECNOLÓGICOS E METODOLÓGICOS

Anais do Colóquio Internacional "Educação e Contemporaneidade" (2021)

Luciana de Lima Augusto Feynman Dias Nobre Thayana Brunna Queiroz Lima Sena

The objective is to describe the technological and methodological aspects of undergraduate students who participated in the Pedagogical Residence (RP) of Biology at the Federal University of Ceará (UFC).The research is exploratory with the application of a questionnaire with 20 graduates of the RP Program between 2018 and 2019.In the data analysis, inferences based on the Discursive Textual Analysis were developed.Together with these procedures, the frequencies of the results obtained were calculated considering three categories: digital equipment, digital resources, and methodological approaches.It is inferred that the residents were guided by expository classes, centered on the teacher using their digital equipment for the presentation of content through digitized audiovisual resources.

10.29380/2021.15.08.01

Cite

Citations (0)