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Raúl Aguirre‐Gamboa

University of Chicago

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Cisca Wijmenga

University Medical Center Groningen

Mihai G. Netea

Radboud University Nijmegen

Yang Li

Helmholtz Centre for Infection Research

Lude Franke

University Medical Center Groningen

Vinod Kumar

Radboud University Nijmegen

Leo A. B. Joosten

Iuliu Hațieganu University of Medicine and Pharmacy

Sebo Withoff

University Medical Center Groningen

Serena Sanna

Institute of Genetic and Biomedical Research

Iris H. Jonkers

University Medical Center Groningen

Hans J. P. M. Koenen

Radboud University Nijmegen

Cooperative Institutions

University of Groningen

University Medical Center Groningen

Radboud University Nijmegen

Radboud University Medical Center

University Medical Center

Radboud Institute for Molecular Life Sciences

University of Chicago

Harvard University

University Medical Center Utrecht

Utrecht University

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GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology

Immunity (2023)

Zachary M. Earley Wioletta Lisicka Joseph Sifakis Raúl Aguirre‐Gamboa Anita Kowalczyk

10.1016/j.immuni.2022.12.009

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Citations (16)

BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses

Immunity (2024)

Sarah Sun Raúl Aguirre‐Gamboa L. Charlotte J. de Bree Joaquín Sanz Anne Dumaine

Progenitor

10.1016/j.immuni.2024.07.021

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Citations (5)

Additional file 4 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

Figshare (2021)

Xiaojing Chu Martin Jaeger Joep Beumer Olivier B. Bakker Raúl Aguirre‐Gamboa

Additional file 4. Table S4

10.6084/m9.figshare.14921236

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Additional file 19 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

Figshare (2021)

Xiaojing Chu Martin Jaeger Joep Beumer Olivier B. Bakker Raúl Aguirre‐Gamboa

Additional file 19. Table S18

10.6084/m9.figshare.14921206

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GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology

Zenodo (CERN European Organization for Nuclear Research) (2022)

Raúl Aguirre‐Gamboa

10.5281/zenodo.7272314

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Understanding human immune function using the resources from the Human Functional Genomics Project

Nature Medicine (2016)

Mihai G. Netea Leo A. B. Joosten Yang Li Vinod Kumar Marije Oosting

Functional Genomics

10.1038/nm.4140

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Citations (73)

Additional file 20 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

Figshare (2021)

Xiaojing Chu Martin Jaeger Joep Beumer Olivier B. Bakker Raúl Aguirre‐Gamboa

Additional file 20. Table S19

10.6084/m9.figshare.14921212

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Additional file 3 of Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

Figshare (2021)

Xiaojing Chu Martin Jaeger Joep Beumer Olivier B. Bakker Raúl Aguirre‐Gamboa

Additional file 3. Table S3

10.6084/m9.figshare.14921233

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Additional file 2 of A systematic review and functional bioinformatics analysis of genes associated with Crohn’s disease identify more than 120 related genes

Figshare (2022)

Debora Garza-Hernandez Maricruz Sepúlveda-Villegas José Garcia‐Pelaez Raúl Aguirre‐Gamboa Péter L. Lakatos

Additional file 2. List of Pubmed IDs for genes curated trough PubTerm.

10.6084/m9.figshare.19593933

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Transmission of stimulus-induced epigenetic changes through cell division is coupled to continuous transcription factor activity

Frontiers in Immunology (2023)

Sarah Sun Raúl Aguirre‐Gamboa Luis B. Barreiro

Trained immunity, or innate immune memory, has been attributed to the long-term retention of stimulus-induced histone post-translational modifications (PTMs) following clearance of the initial stimulus. Yet, it remains unknown how this epigenetic memory can persist for months in dividing cells given the lack of any known mechanism for stimulus-induced histone PTMs to be directly copied from parent to daughter strand during DNA replication. Here, using time course RNA-seq, ChIP-seq, and infection assays, we find that trained macrophages are transcriptionally, epigenetically, and functionally re-programmed for at least 14 cell divisions after stimulus washout. However, the epigenetic changes observed after multiple rounds of cell division do not result from the self-sustained propagation of stimulus-induced epigenetic changes through cell division. Instead, long-lasting epigenetic differences between trained and non-trained cells are always coupled with changes in transcription factor (TF) activity, emphasizing the central role played by TFs, and gene expression changes more broadly, in driving the transmission of stimulus-induced epigenetic changes across cell divisions.

Stimulus (psychology)

Epigenesis

10.3389/fimmu.2023.1129577

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Citations (6)

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