Masaharu Mandai

Osaka Medical and Pharmaceutical University

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Narutsugu Emura

Osaka Medical and Pharmaceutical University

Hiroshi Yoneda

Osaka Hospital

Yasushi Yoshida

Chiba University

Hitoshi Matsumura

Fukuoka University Hospital

Manabu Sakao

Kenji Kuroda

Asahikawa Medical College Hospital

Toshiaki Sakai

Furukawa Electric (Japan)

Takahito Urakami

Osaka Medical and Pharmaceutical University

Seiji Satani

Osaka Hospital

Kenji Kuroda

National Hospital Organization

Cooperative Institutions

Osaka Medical and Pharmaceutical University

National Hospital Organization

Akita University

Tsurumi University

Osaka University

Osaka Metropolitan University

Osaka City University

The University of Tokyo

Asahikawa Medical College Hospital

Osaka University of Pharmaceutical Sciences

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Two cases of HLA‐DR2‐negative hypersomnia manifesting sleep‐onset rapid eye movement periods in the multiple sleep latency test

Psychiatry and Clinical Neurosciences (1999)

Yasushi Yoshida Kenji Kuroda Masaharu Mandai Seiji Satani Narutsugu Emura

We encountered two cases expressing excessive daytime sleepiness (EDS) and manifesting two or more sleep‐onset rapid eye movement (REM) periods in the multiple sleep latency test. Unbearable daytime sleepiness occurred abruptly, which usually led to short‐lasting naps, after which the patients felt refreshed. The EDS was successfully reduced by treatment with methylphenidate. In spite of these features similar to narcolepsy, these cases of REM hypersomnia did not present cataplexy or other auxiliary symptoms of narcolepsy, and, furthermore, the class‐II human leukocyte antigen DR2 appeared to be negative.

Sleep

Sleep Stages

10.1046/j.1440-1819.1999.00525.x

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PS-12-7 The influences of bright light exposure with mecobalamine (methycobal®) infusion on ERPs

Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control (1995)

Manabu Sakao Masaharu Mandai Narutsugu Emura Yoshinobu Nomura Kenji Kuroda

10.1016/0924-980x(95)92832-7

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Prostaglandin E (EP) receptor subtypes and sleep

Neuroreport (2000)

Yasushi Yoshida Hitoshi Matsumura Tomoko Nakajima Masaharu Mandai Takahito Urakami

Prostaglandin (PG) E2 reportedly augmented wakefulness when continuously infused into the third ventricle of the rat brain, whereas it promoted sleep when continuously infused into the subarachnoid space of the ventral surface zone of the rostral basal forebrain, which was designated previously as a PGD2-sensitive sleep-promoting zone (PGD2-SZ). In the present study, we investigated the effects of PGE (EP)-receptor agonists on sleep-wakefulness activities by infusing agonists into the third ventricle or into the subarachnoid space of the PGD2-SZ. Our results indicated that the waking effect is mediated by EP1 and EP2 receptors situating around the third ventricle, whereas the sleep-promoting effect is brought about mainly through activation of EP4 receptors located at or near the subarachnoid space of the PGD2-SZ.

Subarachnoid space

Sleep

Prostaglandin D2

Forebrain

Prostaglandin E2 receptor

10.1097/00001756-200007140-00014

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Citations (29)

PS-45-7 Changes of event-related potentials during abstaining period in alcoholics

Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control (1995)

Masaharu Mandai Manabu Sakao Sei-ichi Kawada Kenji Kuroda Shinichiro Miyazaki

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