Nobuhiro Marubayashi

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ChemInform Abstract: Stereoselective Oxidation of 2‐(4‐Chlorophenyl)‐4a,5‐dihydro‐2H‐(1) benzothiopyrano(4,3‐c)pyridazin‐3(4H)‐one to Sulfoxide.

ChemInform (1991)

T Nakao M. OBATA M Kawakami Nobuhiro Marubayashi Kenji Morita

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Sulfoxide

10.1002/chin.199123163

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Monoterpene Alkaloids from Incarvillea sinensis. VI. Absolute Stereochemistry of Incarvilline and Structure of a New Alkaloid, Hydroxyincarvilline.

Chemical and Pharmaceutical Bulletin (1997)

Yu‐Ming Chi Fumio Hashimoto Wen‐Mei Yan Toshihiro Nohara Masami Yamashita

The absolute configuration of incarvilline (1), an important core compound of a number of alkaloids isolated from Incarvillea sinensis LAM., has been determined by the application of Mosher's method and X-ray crystallographic analysis of incarvilline methiodide (1a). Furthermore, the structure of hydroxyincarvilline (2) was also determined by spectroscopic means.

Monoterpene

Methiodide

Absolute Configuration

10.1248/cpb.45.495

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Citations (22)

(4RS,1'RS)-Methyl 1-Phenyl-2-piperidinoethyl 1,4-Dihydro-2,6-dimethyl-4-(2-thienyl)pyridine-3,5-dicarboxylate Methanol Solvate, C₂₇H₃₂N₂O₄S.1.5CH₄O

Acta Crystallographica Section C Crystal Structure Communications (1997)

Nobuhiro Marubayashi Tadashi Mishina Toshio Hamasaki Noriaki Hirayama

The two independent molecules in the asymmetric unit have similar conformations. The 4-thienyl-1,4-dihydropyridine moieties adopt a flat boat conformation commonly observed for 4-aryl-1,4-dihydropyridine derivatives with the 4-thienyl group in a pseudoaxial orientation. The thienyl and phenyl rings are perpendicular to each other. The six methanol molecules in the unit cell stabilize the crystal structure through intermolecular hydrogen bonds involving the N atoms of the dihydropyridine and the piperidine rings of both molecules.

Piperidine

10.1107/s0108270197000528

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Crystal Structure of α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-1-piperidine-propanol (Biperiden)

Analytical Sciences (1999)

Nobuhiro Marubayashi Masami Yamashita Noriaki Hirayama

Piperidine

Propanol

10.2116/analsci.15.815

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Citations (2)

Studies on the constituents of marine opisthobranchia, IV. Two new polyhalogenated monoterpenes from the sea hare Aplysia kurodai

Liebigs Annalen der Chemie (1988)

Tomofumi Miyamoto Ryuichi Higuchi Nobuhiro Marubayashi Tetsuya Komori

Abstract A new cyclic monoterpene, aplysiaterpenoid A ( 1 ), and a new acyclic monoterpene, aplysiaterpenoid B ( 2 ), have been isolated from the marine mollusk, Aplysia kurodai (Aplysiidae), and their structures were determined by chemical, spectral, and X‐ray structural investigations.

Opisthobranchia

Monoterpene

Aplysia

10.1002/jlac.198819881215

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Citations (15)

Studies on the constituents of Atractylodes lancea.

Chemical and Pharmaceutical Bulletin (1989)

Shoji Yahara Tomoko Higashi K. Iwaki Toshihiro Nohara Nobuhiro Marubayashi

From the polar portion of the methanolic extract of the fresh rhizomes of Atractylodes lancea DC., nine new sesquiterpene glycosides [two guaiane-type glycosides, atractylosides A and B (1 and 2), and seven eudesmane-type glycosides, atractylosides C, D, E, F, G, H and I (3-9)] were obtained and their structures were characterized by enzymatic hydrolysis, spectroscopic means and X-ray analysis.

Atractylodes

Aglycone

10.1248/cpb.37.2995

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Citations (33)

Biologically active glycosides from asteroidea, XXVII. Stereochemistry of the C‐17 side chain of 26‐homothornasterol B: Novel triethylaluminum‐promoted rearrangement and alkylation of epoxy alcohols

Liebigs Annalen der Chemie (1991)

Masanori Honda Takashi Igarashi Nobuhiro Marubayashi Tetsuya Komori

Abstract The absolute configuration of 3,6‐di‐ O ‐acetyl‐26‐homothornasterol B ( 3 ) obtained previously besides the 3,6‐di‐ O ‐acetyl derivative ( 2 ) of (20 S ,24 S )‐24‐ethylthornasterol A by aldol reaction 2a) of the mixture of (3 S )‐3‐ethyl‐4‐methyl‐2‐(trimethylsiloxy)‐1‐pentene ( 7 ) and 3,4‐dimethyl‐2‐(trimethylsiloxy)‐1‐hexene ( 8 ) with (+)‐diacetylasterone ( 1 ) has been determined by X‐ray structural analysis as (20 S ,24 S ,25 R )‐3β,6α‐diacetoxy‐20‐hydroxy‐24‐methyl‐26‐homo‐5α‐cholest‐9(11)‐en‐23‐one. On the basis of these results a novel rearrangement and alkylation of the epoxy alcohols 6, 9, 13 , and 15 with triethylaluminium have been discovered and investigated. The reaction occurs when the C‐4 position adjacent to the epoxide ring is congested.

Side chain

Aldol reaction

Derivative (finance)

10.1002/jlac.1991199101108

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Citations (6)

Molecular Conformation of 2′-Deoxy-2′-methylidene-cytidine: A Potent Antineoplastic Nucleoside

Nucleosides and Nucleotides (1992)

Yuriko Yamagat Ken‐ichi Tomita Nobuhiro Marubayashi Ikuhiko Ueda Shinji Sakata

Abstract 2′-Deoxy-2′-methylidenecytidine (DMDC), a potent inhibitor of the growth of tumor cells, was crystallized with two different forms. One is dihydrated (DMDC·2H2O) and the other is its hydrochloride salt (DMDC·HCLl). Both crystal and molecular structures have been determined by the X-ray diffraction method. In both forms the glycosidic and sugar conformations are anti and C(4′)-exo, respectively, whereas the conformation about the exocyclic bond is trans for DMDC·2H2O and gauche + for DMDC·HCl. Proton nuclear magnetic resonance data of DMDC indicate a preference for the anti C(4′)-exo conformation found in the solid state. These molecular conformations were compared with the related pyrimidine nucleosides. When the cytosine bases are brought into coincidence, DMDC displays the exocyclic C(4′)-C(5′) bond located on the very close position to those of pyrimidine nucleosides with typical overall conformations. On the other hand, the hydroxyl O(3′)-H groups are separated by ca. 3 Å in the cases of DMDC and other pyrimidine nucleosides which have the C(2′)-endo sugar conformation. This result may be useful for the implication about the mechanism of the biological activity of DMDC.

Cytidine

Molecular model

Cytosine

10.1080/07328319208021744

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Citations (5)

ChemInform Abstract: Biologically Active Glycosides from Asteroidea. Part 29. X‐Ray Crystallographic Analysis of Desulfated Asterosaponin P1 Isolated from the Starfish Asterina pectinifera.

ChemInform (1992)

Y. Cho Ryota Higuchi Nobuhiro Marubayashi I. Ueda Tetsuya Komori

10.1002/chin.199216280

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ChemInform Abstract: Copper(II) and Nickel(II) Complexes of N,N′,N′′,N′′′‐Tetrakis(2‐aminoethyl)‐1,4,7,11‐tetraazacyclotetradecane (taei), ‐1,4,8,12‐tetraazacyclopentadecane (taep), and ‐1,5,9,13‐tetraazacyclohexadecane (taeh). Crystal Structures of (Cu2(taep))(ClO4)4, (Cu2(taeh))(ClO4)4, and (Cu2(N3)(taeh))(ClO4)3.

ChemInform (1990)

Ichiro Murase I. Ueda Nobuhiro Marubayashi S. Kida Naohide Matsumoto

Abstract The new octamine dinucleating ligands (I) are synthesized by a known method reacting the parent tetraazamacrocycles with N‐tosylaziridine in refluxing acetonitrile, followed by treatment with HBr/acetic acid.

10.1002/chin.199051331

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