Lim Yok Zuan

Singapore Immunology Network

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Sharrada Subramaniam

Singapore Immunology Network

Juan J. Lafaille

New York University

Michael Poidinger

Singapore Immunology Network

Sabrina S. Joseph

Henry M. Jackson Foundation

Lakshmi Ramakrishna

SingHealth Duke-NUS Academic Medical Centre

Glenn Wong

Singapore Immunology Network

Sriram Narayanan

Institute of Molecular and Cell Biology

Leigh Ann Jones

Society of Thoracic Surgeons

Deng Xiangying

Singapore Immunology Network

Aina Hoi

Bioprocessing Technology Institute

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Singapore Immunology Network

Agency for Science, Technology and Research

New York University

Howard Hughes Medical Institute

Institute of Biomedical Science

Institute of Molecular and Cell Biology

York University

National University of Singapore

National Institutes of Health

The Ohio State University

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The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response

The Journal of Experimental Medicine (2013)

Jin‐Shu He Michael Meyer‐Hermann Deng Xiangying Lim Yok Zuan Leigh Ann Jones

The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE+ cells in memory responses is particularly unclear. IgE+ B cell differentiation is characterized by a transient GC phase, a bias toward the plasma cell (PC) fate, and dependence on sequential switching for the production of high-affinity IgE. We show here that IgE+ GC B cells are unfit to undergo the conventional GC differentiation program due to impaired B cell receptor function and increased apoptosis. IgE+ GC cells fail to populate the GC light zone and are unable to contribute to the memory and long-lived PC compartments. Furthermore, we demonstrate that direct and sequential switching are linked to distinct B cell differentiation fates: direct switching generates IgE+ GC cells, whereas sequential switching gives rise to IgE+ PCs. We propose a comprehensive model for the generation and memory of IgE responses.

10.1084/jem.20131539

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