Xiuqin Yang

China Pharmaceutical University

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Zhiyin Xiao

Gannan Normal University

Fulai Yang

China Pharmaceutical University

Jing Jin

Wuhan Textile University

Yishu Bao

Chinese University of Hong Kong

Qingfa Zhou

China Pharmaceutical University

Zhuming Guo

Capital Medical University

Xiaoming Liu

Beijing Institute of Technology

Yabing He

Zhejiang Normal University

L.‐W. Antony Chen

University of Nevada, Las Vegas

Binyu Xu

Nanchang University

Cooperative Institutions

China Pharmaceutical University

Chinese Academy of Sciences

Jiaxing University

Shanghai Jiao Tong University

Nanchang University

Zhejiang Normal University

Liaoning Normal University

Huazhong University of Science and Technology

State Key Laboratory of Natural Medicine

University of Science and Technology of China

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Phosphine-mediated domino reactions of phthalimidomalonates with allenoates or but-2-ynoate: facile entry into highly functionalized pyrroloisoindolinone derivatives

Organic Chemistry Frontiers (2017)

Zhusheng Huang Qingqing Chen Xiuqin Yang Yang Liu Li Zhang

A phosphine-mediated γ-umpolung/Wittig/γ-umpolung reaction between phthalimidomalonates and allenoates/but-2-ynoate furnishes highly functionalized pyrroloisoindolinone derivatives in synthetically useful yields.

Domino

Domino Effect

10.1039/c6qo00775a

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Citations (15)

Catalyst-free sulfenylation of indoles with sulfinic esters in ethanol

Green Chemistry (2018)

Xiuqin Yang Yishu Bao Zonghao Dai Qingfa Zhou Fulai Yang

A novel catalyst-free method for the synthesis of structurally diverse indole thioethers in moderate to excellent yields.

Sulfinic acid

10.1039/c8gc01764f

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Citations (49)

Iodine-Promoted Deoxygenative Iodization/Olefination/Sulfenylation of Ketones with Sulfonyl Hydrazides: Access to β-Iodoalkenyl Sulfides

Organic Letters (2018)

Yishu Bao Xiuqin Yang Qingfa Zhou Fulai Yang

A highly regio- and stereoselective synthesis of β-haloalkenyl sulfides using commercially available ketones and sulfonyl hydrazides as starting materials has been developed. This protocol obviates the need for alkynes and traditional sulfenylating agents and therefore opens up a new door to construct β-iodoalkenyl sulfides in a highly simple manner. This study reveals that ketones could be used as vinyl iodide precursors in organic synthesis.

Sulfonyl

10.1021/acs.orglett.8b00511

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Citations (30)

CCDC 1848783: Experimental Crystal Structure Determination

The Cambridge Structural Database (2018)

Zhiyin Xiao Ran Jiang Jing Jin Xiuqin Yang Binyu Xu

10.5517/ccdc.csd.cc201t52

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Citations (0)

CCDC 1963449: Experimental Crystal Structure Determination

The Cambridge Structural Database (2020)

Xiuqin Yang Jing Jin Zhuming Guo Zhiyin Xiao L.‐W. Antony Chen

10.5517/ccdc.csd.cc23x428

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Further exploration of the reaction between cis‐[Fe(CO)₄I₂] and alkylamines: An aminium salt of fac‐[Fe(CO)₃I₃]⁻ or an amine‐bound complex of fac‐[Fe(CO)₃I₂(NH₂R)]?

Applied Organometallic Chemistry (2021)

Jinzhong Guo Zhuming Guo Zhiyin Xiao Jing Jin Xiuqin Yang

Four new monoiron (II) tricarbonyl complexes with the amine bound, fac ‐[Fe(CO) 3 I 2 (NH 2 R)] (R = Et, 1 ; n Pr, 2 ; n Bu, 3 ; n Pent, 4 ), were reported using cis ‐[Fe(CO) 4 I 2 ] as the precursor. All the complexes 1 – 4 were structurally confirmed by various techniques such as ultraviolet–visible (UV–vis), Fourier transform infrared (FTIR), and nuclear magnetic resonance (NMR) spectra and elemental analysis of which complexes 1 and 2 are crystallographically determined. The reaction of the precursor with alkylamines proceeded in two main parallel pathways to form both aminium salts of fac ‐[Fe(CO) 3 I 3 ] − and the amine‐bound complexes ( 1 – 4 ). Their dominances altered with the reaction time. These complexes in DMSO undergo quick decomposition with complex 1 as the relatively most stable one ( t 1/2 = 7.3 min) although they are stable in solid status. Unlike the triiodo anion and pyridinyl analogs showing severe cytotoxicity due to the generation of iodine radical during the decomposition, no iodine radicals were detected from the fac ‐[Fe(CO) 3 I 2 (NH 2 R)] complexes. Therefore, the cell viability of RT112 cells was not affected by the presence of the amine‐bound iron complex ( 1 ) up to 100 μmol L −1 .

10.1002/aoc.6280

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Citations (4)

CCDC 2057374: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Jinzhong Guo Zhuming Guo Zhiyin Xiao Jing Jin Xiuqin Yang

10.5517/ccdc.csd.cc271vx2

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CCDC 1848782: Experimental Crystal Structure Determination

The Cambridge Structural Database (2018)

Zhiyin Xiao Ran Jiang Jing Jin Xiuqin Yang Binyu Xu

10.5517/ccdc.csd.cc201t41

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Citations (0)

CCDC 1848780: Experimental Crystal Structure Determination

The Cambridge Structural Database (2018)

Zhiyin Xiao Ran Jiang Jing Jin Xiuqin Yang Binyu Xu

10.5517/ccdc.csd.cc201t2z

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Diiron(ii) pentacarbonyl complexes as CO-releasing molecules: their synthesis, characterization, CO-releasing behaviour and biocompatibility

Dalton Transactions (2018)

Zhiyin Xiao Ran Jiang Jing Jin Xiuqin Yang Binyu Xu

Four diiron(ii) carbonyl complexes, [Fe2(μ-SR)3(CO)5X] (X- = Br-, I-; R = CH2CH3, CH2CH2CH3) were facilely synthesized by reacting [Fe(CO)4X2] with monothiolates. Their potential as carbon monoxide-releasing molecules (CORMs) was systematically investigated, revealing that their CO-releasing behaviour is highly solvent-dependent. Specifically, in dimethyl sulfoxide (DMSO), the CO-releasing kinetics were fast. Intermediates with a lower oxidation state might be involved in the reaction. By contrast, in less polar solvents such as methanol, acetonitrile and dichloromethane, intermediates featuring the triiron carbonyl cation, [Fe3(μ-SCH2CH3)6(CO)6]+, were isolated. The triiron intermediate underwent further decomposition to liberate CO. One of the iodo complexes was also examined for its CO-release in PBS solution when solubilised with DMSO in the presence of deoxy-Mb and the CO-release was found to be quantitative. Furthermore, kinetic analyses were performed and the CO-release in general obeyed a first-order kinetic model. Plausible CO-releasing pathways are proposed for the parent complexes and the triiron intermediate. Assessments in cytotoxicity indicated that the cytoxicity of the diiron(ii) complexes varied with both the halide and thiolate and those bearing bromide and the thiolate with longer chains were more biocompatible.

Biocompatibility

10.1039/c8dt03982h

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Citations (18)