Makarios Eleftheriades

National and Kapodistrian University of Athens

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Alexandros Sotiriadis

Aristotle University of Thessaloniki

Nikolaos Vlahos

National and Kapodistrian University of Athens

Panagiota Pervanidou

National and Kapodistrian University of Athens

Emmanouil Manolakos

University of Ioannina

ΙL

Ιrene Lambrinoudaki

National and Kapodistrian University of Athens

Christos Chatzakis

Aristotle University of Thessaloniki

Anna Eleftheriades

University Hospital of Basel

Konstantinos Panoulis

Aretaeio Hospital

Ioannis Papastefanou

King's College London

Konstantinos Dinas

Aristotle University of Thessaloniki

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National and Kapodistrian University of Athens

191

Aretaeio Hospital

Aristotle University of Thessaloniki

Alexandra Hospital

LETO Maternity Hospital

University General Hospital Attikon

Athens State University

Ippokrateio General Hospital of Thessaloniki

Athens Medical Center

Children's Hospital Agia Sophia

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Safety of COVID-19 Vaccination in Pregnancy: A Systematic Review

Diagnostics (2024)

Angeliki Gerede G. Daskalakis Themistoklis Mikos Christos Chatzakis Εleftherios Vavoulidis

The COVID-19 pandemic has posed significant risks to pregnant women and those recently pregnant, leading to heightened mortality and morbidity rates. Vaccination has emerged as a pivotal strategy in reducing COVID-19-related deaths and illnesses worldwide. However, the initial exclusion of pregnant individuals from most clinical trials raised concerns about vaccine safety in this population, contributing to vaccine hesitancy. This review aims to consolidate the existing literature to assess the safety and efficacy of COVID-19 vaccination in pregnant populations and neonatal outcomes. Diverse studies were included evaluating various aspects of safety for women and their newborns, encompassing mild to severe symptoms across different vaccines. The findings indicate the overall safety and efficacy of COVID-19 vaccination, with minimal adverse outcomes observed, including mild side effects like pain and fever. Although most studies reported the absence of severe adverse outcomes, isolated case reports have raised concerns about potential associations between maternal COVID-19 vaccination and conditions such as fetal supraventricular tachycardia and immune-mediated diseases. Our review underscores the importance of ongoing surveillance and monitoring to ensure vaccine safety in pregnant women. Overall, COVID-19 vaccination during pregnancy remains a safe and effective strategy, emphasizing the need for continued research and vigilance to safeguard maternal and fetal health.

Pandemic

10.3390/diagnostics14161775

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Assessment of body composition in Wistar rat offspring by DXA in relation to prenatal and postnatal nutritional manipulation

Pediatric Research (2016)

Makarios Eleftheriades Homeira Vafaei Ismene Dontas George Vaggos K. Marinou

10.1038/pr.2016.61

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Citations (16)

Preeclampsia and Cerebral Palsy in Offspring

Children (2022)

Miltiadis Badagionis Theodoros Ν. Sergentanis Panagiota Pervanidou Emmanouil Kalampokas Nikolaos Vlahos

The aim of this systematic review and meta-analysis is to examine the association between exposure to preeclampsia during pregnancy and the occurrence of cerebral palsy in offspring. For this reason, the authors searched PubMed/Medline, EMBASE, and Google Scholar databases (end-of-search: 22 November 2021) and identified the most relevant studies. Then, a meta-analysis of all the eligible studies was performed. Subgroup and meta-regression analyses by study design, degree of adjustment, and geographical region were also conducted. A total of 10 studies were finally included, and no statistical significance was noted in the association between preeclampsia and cerebral palsy (pooled OR = 1.16, 95% CI: 0.77–1.74). The subgroup of studies that provided adjusted odds ratios for any variable except for gestational age showed a statistically significant association (pooled OR = 1.62, 95% CI: 1.36–1.93), whereas the association dissipated in studies also adjusting for gestational age (pooled OR = 1.63, 95% CI: 0.48–5.50). In conclusion, it seems that preeclampsia is not associated with cerebral palsy independently of gestational age; however, further research is needed to shed light on this topic.

10.3390/children9030385

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Pregnancy outcomes in the different phenotypes of gestational diabetes mellitus based on the oral glucose tolerance test. A systematic review and meta-analysis

Diabetes Research and Clinical Practice (2023)

Christos Chatzakis Anna Eleftheriades Eleftheria Demertzidou Konstantinos Dinas Nikolaos Vlahos

Glucose tolerance test

10.1016/j.diabres.2023.110913

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Citations (6)

First trimester prediction of small‐ and large‐for‐gestation neonates by an integrated model incorporating ultrasound parameters, biochemical indices and maternal characteristics

Acta Obstetricia Et Gynecologica Scandinavica (2011)

Ioannis Papastefanou Athena P. Souka Athanasios Pilalis Makarios Eleftheriades Vasiliki Michalitsi

Abstract Objective. To identify maternal/pregnancy characteristics, first trimester ultrasound parameters and biochemical indices which are significant independent predictors of small‐for‐gestational age (SGA) and large‐for‐gestational age (LGA) neonates. Design. Retrospective cross‐sectional study. Setting. Two fetal Medicine Units. Population. 4 702 singleton pregnancies presenting for screening for chromosomal abnormalities by nuchal translucency and maternal serum biochemistry at 11–14 weeks. Methods. Reference ranges for birthweight applied to our population were constructed by the Royston and Wright method. Multiple logistic regression was applied to develop first trimester prediction models for SGA and LGA. Main outcome measures. Birth of SGA or LGA neonate. Results. Maternal height, parity, smoking, assisted conception, delta crown–rump length, delta nuchal translucency, free beta human chorionic gonadotrophin and pregnancy‐associated plasma protein‐A were significant independent predictors of SGA. Maternal weight and height, smoking, delta crown–rump length and delta nuchal translucency were significant independent predictors of LGA. Models for SGA (AUC=0.7296, CI: 0.69–0.76, p <0.0001) and LGA (AUC=0.6901, CI: 0.65–0.72, p <0.0001) were derived, applicable to routine obstetric population at low risk for these conditions. For 20% screen positive rate the modeling achieves sensitivities of about 55% for SGA and 48% for LGA neonates. Conclusion. Prediction for birthweight deviations is feasible using data available at the routine 11–14 weeks’ examination. Delta CRL and delta nuchal translucency were significant independent predictors for both SGA and LGA.

Crown-rump length

10.1111/j.1600-0412.2011.01271.x

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Visceral Leishmaniasis in a Twin Pregnancy: A Case Report and Review of the Literature

Journal of Clinical Medicine (2024)

Grigorios Karampas Sevasti Koulouraki George L. Daikos Christina Nanou Leon Aravantinos

Visceral leishmaniasis (VL), often referred to as kala-azar, is quite rare in developed countries during pregnancy. Only few studies have evaluated its impact on perinatal outcome. It is caused primarily by Leishmania donovani or Leishmania infantum and presents with a wide spectrum of clinical manifestations from cutaneous ulcers to multisystem disease. Differential diagnosis is challenging as symptoms and signs are insidious, mimicking other diseases. Misdiagnosis can result in severe adverse perinatal outcomes, even maternal/neonatal death. Early treatment with liposomal amphotericin-B (LAmB) is currently the first choice with adequate effectiveness. We report a rare case of VL in a twin pregnancy with onset at the second trimester, presenting with periodic fever with rigors, right flank pain, and gradual dysregulation of all three cell lines. The positive rK39 enzyme-linked immunosorbent assay test confirmed the diagnosis. Treatment with LAmB resulted in clinical improvement within 48 h and in the delivery of two late-preterm healthy neonates with no symptoms or signs of vertical transmission. The one-year follow-up, of the mother and the neonates, was negative for recurrence. To our knowledge, this is the first reported case of VL in a twin pregnancy, and consequently treatment and perinatal outcome are of great importance.

Twin Pregnancy

Rare disease

10.3390/jcm13082400

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The severity of hot flashes is associated with the risk for incident metabolic syndrome and new-onset hypertension after the menopause

Endocrine Abstracts (2023)

Eleni Armeni Areti Augoulea Andreas Efstathiou Panagiota Chatzivasileiou George Kaparos

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

10.1530/endoabs.90.oc4.6

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The Role of the Mediterranean Diet in Assisted Reproduction: A Literature Review

Nutrients (2024)

Dimitris Baroutis Theodoros Kalampokas Eleni Katsianou Alexandros Psarris G. Daskalakis

The Mediterranean Diet, characterized by high consumption of plant-based foods, olive oil, moderate intake of fish and poultry, and low consumption of red meat and processed foods, has been suggested to improve assisted reproductive technology (ART) outcomes. This narrative review aimed to summarize and synthesize the evidence from observational studies on the associations between preconception adherence to the Mediterranean Diet and ART outcomes. PubMed/MEDLINE, Embase, ScienceDirect, Google Scholar, and Web of Science databases were searched to identify relevant studies. Seven observational studies (

Mediterranean Diet

10.3390/nu16162807

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Maternal serum levels of neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9) and their complex MMP-9/NGAL in pregnancies with preeclampsia and those with a small for gestational age neonate: a longitudinal study

Prenatal Diagnosis (2014)

Grigorios Karampas Makarios Eleftheriades Konstantinos Panoulis Myrto Rizou Alexander Haliassos

Background The aim of this study was to determine maternal serum concentrations of neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9), and MMP-9/NGAL complex longitudinally in pregnancy, in normal pregnancies, in pregnancies that developed preeclampsia and in pregnancies that delivered a small for gestational age infant (SGA). Methods Neutrophil gelatinase-associated lipocalin, MMP-9, and MMP-9/NGAL were determined in the first, second, and third trimesters in 33 normal pregnancies, 12 pregnancies complicated by preeclampsia, and 14 pregnancies that delivered a SGA neonate. Results Median NGAL concentration (ng/mL) in normal pregnancies increased significantly from 12.8 in the first trimester to 25.9 in the second trimester (p = 0,002) and 48.0 (p < 0.0001) in the third trimester. In preeclamptic pregnancies, NGAL was significantly higher, compared with normal pregnancies, in the first (30.9; p = 0.006) and second (44.6; p = 0.015) trimesters. MMP-9 and MMP-9/NGAL complex concentrations in preeclamptic pregnancies did not differ significantly from normal pregnancies in either trimester. Pregnancies with an SGA infant did not have different marker concentrations in either trimester, compared with normal pregnancies. Conclusion Maternal serum NGAL, MMP-9, and MMP-9/NGAL complex concentrations tend to increase during pregnancy in normal and preeclamptic pregnancies. NGAL was significantly elevated in the first and second trimesters, in pregnancies that later developed preeclampsia. © 2014 John Wiley & Sons, Ltd.

Neutrophil gelatinase-associated lipocalin

Matrix metalloproteinase 9

10.1002/pd.4337

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Citations (23)

Investigating the Link between Early Life and Breast Anomalies

Children (2023)

Panagiotis Christopoulos Alkis Matsas Makarios Eleftheriades Georgia Kotsira Anna Eleftheriades

Several factors during childhood and adolescence are thought to be associated with the development of proliferative benign breast diseases and breast cancer in adulthood. In order to identify them, the authors conducted an extensive review of the literature up to October 2022, searching for clinical studies, reports, and guidelines in English. A thorough Medline/Pubmed and Google scholar database research was performed, investigating the link between diet, exercise, age of menarche, body mass index, ionizing radiation exposure during childhood and adolescence, and proliferative breast diseases and breast cancer in adulthood. A list of keywords, including breast disorders, adolescence, childhood, and breast cancer was included in our search algorithm. Numerous studies concede that the development of breast disease in adulthood is influenced by various risk factors, whose influence begins during early childhood and adolescence.

Menarche

Breast development

10.3390/children10030601

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Citations (3)