A surplus seedling was found during survey germ plasma resources of Chinese Chestnut (Castanea mollissima Bl.) in Anhui province in 1993. Based on appraisal of its vegetative plants, it is shown that it has strong ability to produce more pistillate flowers and strong resistance to pruning and detrimental conditions, and that it produces early fruits (the last ten days of August) with high yield and good quality. Its nuts are big (average weight is 25.0 g), and they are shiny and attractive. After the branches of young trees are heavily cut, the fruits mature relatively late (the last ten days of November) on the sprouts. The nuts can be stored for a long time (those in bracts can be stored till the next March). Its quality is good and its commercial value is high.
The administration of You Gui Wan (YGW) decoction has been observed to improve vaginal atrophy induced by ovariectomy (OVX) in rats. The aim of the current study was to explore the possible mechanisms underlying this effect. Following OVX, 37 Sprague Dawley female rats were randomly divided into three groups which were orally administered with YGW decoction, saline or estrogen for 11 weeks. In parallel with this, 19 normal and 17 rats with sham‑surgery were used as controls. The effects of these treatments on estrogen receptors (ER) and various angiogenic factors, including vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor‑1 (VEGFR‑1), angiopoietin (Ang)1 and 2 and basic fibroblast growth factor (bFGF) in the vagina were compared using immunohistochemistry or quantitative polymerase chain reaction (qPCR). OVX was found to induce significant vaginal atrophy and decrease the expression of ER and various angiogenic factors when compared with the normal and sham‑surgery animals (all P<0.05). Estrogen replacement and the administration of YGW decoction reversed the vaginal atrophic process. The hormonal replacement and YGW treatment recovered the protein expression of ER‑α and ‑β, VEGF and VEGFR‑1 and the mRNA levels of ER‑α, VEGF, VEGFR‑1, Ang1 and 2, and bFGF when compared with OVX‑rats with saline, normal and sham‑surgery treatments (all P<0.05). Thus, it may be concluded that a possible mechanism underlying the effect of YGW on OVX‑induced vaginal atrophy may be the upregulated expression of ER and various angiogenic factors in the vaginal tissue.
An improved cellular genetic algorithm (cGA) is proposed to study the optimization of the job-shop scheduling problem (JSP). Combining with the characteristics of JSP, a sequence-based coding mechanism is presented. The small overlapped neibhborhoods of cGA help to enhance the population diversity and exploration. An adaptive selection operation based on fitness of neighborhood is designed to prevent from getting into local optimal. The improved cellular genetic algorithm is tested on some instances and compared with simple genetic algorithm. The computational results show that the improved cellular genetic algorithm is effective on JSP.
The article have described the optimization of the engine performance problem as nonlinear multi-objective programming, and have analyzed the operation principle of the variable cycle engine, made models of maximum thrust , maximum unit thrust, minimum oil consumption, and then adopts the genetic algorithm to solve the model, gained the guide vane angle of CDFS,the guide vane angle of low-pressure.Turbine and the nozzle throat area when the performance is optimal . It is a problem about multi-objective optimization, obtained a series of satisfactory solution and then selected a set of approximate optimal solution as the final argument. Lastly, The matlab software is used to illustrate the effectiveness of the results.
Influenza virus is a single-stranded RNA virus that causes influenza in humans and animals. About 600 million people around the world suffer from influenza every year. Upon recognizing viral RNA molecules, TLR7 (Toll-like receptor) initiates corresponding immune responses. Traditional Chinese Medicines (TCMs), including Yinqiao powder, Xinjiaxiangruyin and Guizhi-and-Mahuang decoction, have been extensively applied in clinical treatment of influenza. Although the therapeutic efficacy of TCMs against influenza virus in vivo was reported previously, its underlying mechanisms are not clearly understood. This study aimed to investigate the immunological mechanisms in the treatment of influenza virus infected mice with three Chinese herbal compounds as well as the effect on TLR7/NF-κB signaling pathway during recovery.Wild type and TLR7 KO C57BL/6 mice were infected with influenza virus FM1 and then treated with three TCMs. The physical parameters of mice (body weight and lung index) and the expression levels of components in TLR7/NF-κB signaling pathway were evaluated.After viral infection, Guizhi-and-Mahuang decoction and Yinqiao powder showed better anti-viral effect under normal condition. Compared to the viral control group, expression levels of TLR7, MyD88, IRAK4 and NF-κB were significantly reduced in all treatment groups. Furthermore, the three TCM treatment groups showed poor therapeutic efficacy and no difference in viral load compared to the viral control group in TLR7 KO mice.Our study indicated that Guizhi-and-Mahuang decoction and Yinqiao powder might play a crucial role of anti-influenza virus by regulating TLR7/NF-κB signal pathway.
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