Qiannan Hou

University of Electronic Science and Technology of China

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Yonghong Lin

Chengdu Women's and Children's Central Hospital

Lu Huang

Zhejiang Provincial People's Hospital

Xin Li

Sichuan University

Yan Li

Nanchang University

Mingrong Xi

Affiliated Hospital of Shaanxi University of Chinese Medicine

Li He

University of Electronic Science and Technology of China

Dingqian Gu

University of Electronic Science and Technology of China

He Li

Chengdu Women's and Children's Central Hospital

Tianjiao Liu

Chengdu Women's and Children's Central Hospital

Zhaolin Gong

University of Electronic Science and Technology of China

Cooperative Institutions

Chengdu Women's and Children's Central Hospital

University of Electronic Science and Technology of China

Sichuan University

West China Second University Hospital of Sichuan University

Capital Medical University

He University

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Huazhong University of Science and Technology

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Diaphragmatic hernia during pregnancy: A case report with a review of the literature from the past 50 years

Journal of Obstetrics and Gynaecology Research (2011)

Yue Chen Qiannan Hou Zhu Zhang Jian Zhang Mingrong Xi

Abstract Diaphragmatic hernia is a rare complication during pregnancy. Only 30 reports have been published on this subject in English between 1959 and 2009. Due to misdiagnoses and management delays, diaphragmatic hernia usually presents itself as a life‐threatening emergency. Here, we present a case report of a patient with a traumatic diaphragmatic hernia who became acutely symptomatic during pregnancy. The diaphragmatic hernia was managed successfully, and we describe the presentation, management and outcome of this case. We also present a review of all of the reported cases of diaphragmatic hernias complicating pregnancy that have been published in English during the past 50 years.

Presentation (obstetrics)

10.1111/j.1447-0756.2010.01451.x

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Citations (48)

Does transvaginal natural orifice transluminal endoscopic surgery affect female sexual function?: a prospective cohort study

BMC Women s Health (2023)

Dingyu Xu Li He Yonghong Lin Yayu Zhou Zhaolin Gong

To evaluate the effect of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) on female sexual function.

10.1186/s12905-023-02566-y

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Citations (3)

Abstract A25: Variations of human papillomavirus type 16 in cervical, lung, and skin cancers in Sichuan, China

Clinical Cancer Research (2010)

Jian Zhang Tao Wang Min Han Zhihui Yang Min Zhang

Abstract Human papillomavirus (HPV) is closely related with many kinds of cancers such as cervical, lung, and skin cancers, etc. HPV 16 showed intratypic variations that were known to differ in oncogenic potential and geographic distribution. This study was designed to analyze sequence variants in oncogenes E6, E7 and L1 of HPV 16 in cervical, lung, and skin cancers in Sichuan, China. Materials from 138 non-malignant controls, 122 cervical cancer patients, 104 lung cancer patients and 104 skin cancer patients were analyzed by PCR and direct sequencing. The infection rates of HPV 16 in cervical, lung, skin cancers were respectively 68.9%, 17.3%, 5.8%. The Asian prototype was the most prevalent variant in cervical cancer in Sichuan (40%). Compared with that detected in cervical cancer, lung and skin cancers showed more monotonous variations, but several mutations on L1 genes existed only in lung or skin cancers such as G6818C, C7011A, and C7017A. Citation Information: Clin Cancer Res 2010;16(14 Suppl):A25.

10.1158/1078-0432.tcmusa10-a25

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Does Transvaginal Natural Orifice Transluminal Endoscopic Surgery Affect Female Sexual Function?: a Prospective Cohort Study

Research Square (Research Square) (2023)

Dingyu Xu He Li Yonghong Lin Yayu Zhou Zhaolin Gong

Abstract Background To evaluate the effect of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) on female sexual function. Methods: The trial was registered at the Chinese Clinical Trial Registry (ChiCTR2100050887, 07/09/2021). In this prospective cohort study, we prospectively analyzed the data of the female sexual function index (FSFI) questionnaire of 130 patients who underwent laparoscopy in Chengdu Women's and Children's Central Hospital due to gynecological benign diseases. The patients were assigned to the vNOTES group and the control group (underwent traditional laparoscopic surgery or transumbilical laparoendoscopic single-site surgery). Results: There were 4 cases dropout in the vNOTES group and 2 cases dropout in the control group. There was no difference in FSFI scores between the vNOTES group and the control group before and after surgery. There was no difference in postoperative FSFI scores between the vNOTES group and the control group. The time to start sexual life after surgery in the vNOTES group was later than that in the control group (39.34 ± 0.71 d versus 37.86 ± 0.69 d, P < 0.05). Conclusions: vNOTES has no significant adverse effect on female sexual function, however, the time to start sexual life after vNOTES is later than that after trans-abdominal laparoscopy.

10.21203/rs.3.rs-2935160/v1

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Posterior Uterine Fibroid Resection: Which Surgical Approach is More Suitable?

Research Square (Research Square) (2024)

Qiannan Hou Xin Li Lu Huang Qiang Zhang Dan Feng

Abstract Objective: This study aims to objectively assess the effect of three surgical approaches for posterior uterine fibroid resection: transumbilical laparoendoscopic single-site surgery (LESS), vaginal natural orifice transluminal endoscopic surgery (vNOTES) in prone position (vNOTES-P), and vNOTES in the lithotomy position (vNOTES-L). Methods: A retrospective analysis was conducted on data pertaining to all patients who underwent vNOTES and LESSfor single posterior fibroids at our institution from January 2023 to July 2023. Patients were categorized into three groups based on the surgical approach: vNOTES-Pgroup (n=30), vNOTES-L group (n=17), and LESS group (n=32). Comparative analysis was performed on the demographic characteristics and perioperative outcomes among the three groups of patients. Results: All 79 patients underwent surgery without the need for conversion to laparotomy. There were no statistically significant differences among the LESS group, vNOTES-P group, and vNOTES-L group in terms of operative time, intraoperative blood loss, and perioperative complication rates. In the vNOTES-L group, two patients required conversion to LESS during surgery. The time to postoperative flatus was significantly shorter in the vNOTES group compared to the LESS group (P < 0.05). However, three cases of postoperative infection occurred in the vNOTES group, while none were reported in the LESS group. Conclusion: Compared to LESS, vNOTES demonstrates significant advantages in alleviating postoperative pain, shortening time to passage of flatus, and enhancing cosmetic outcomes. Particularly, vNOTES-P for posterior uterine fibroid resection, as an emerging surgical approach, offers certain advantages in facilitating surgical maneuverability and reducing operative time, rendering it more suitable for posterior uterine fibroid resection.

Uterine Fibroids

Lithotomy position

10.21203/rs.3.rs-4407841/v1

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Association of Signal Transducer and Activator of Transcription 3 Gene Polymorphisms with Cervical Cancer in Chinese Women

DNA and Cell Biology (2011)

Kana Wang Bin Zhou Jian Zhang Ya-lan Xin Ting Lai

Signal transducer and activator of transcription (STAT) plays an important role in regulating cell proliferation, differentiation, and apoptosis. Previous studies revealed that abnormal expression/activation of STAT family members were present in a large group of human malignant tumors. In the present study, using polymerase chain reaction (PCR)–restriction fragment length polymorphism, DNA sequencing, and Taqman probe real-time PCR techniques, we analyzed two single-nucleotide polymorphisms (SNPs) in the STAT5B and STAT3 genes (rs6503691 and rs4769793, respectively) in 275 Chinese cervical cancer patients and 340 controls. Our results indicated that the genotype and allele frequencies of SNP rs4769793 were significantly different between the cervical cancer patients and normal subjects (p < 0.05, odds ratio = 1.35, 95% confidence interval = 1. 07–1.70). In addition, stratified analyses revealed that the polymorphism of rs4769793 was also associated with poor tumor differentiation and positive parametrial invasion (p < 0. 05). In contrast, SNP rs6503691 did not show any difference between patients and controls or association with patient clinical characteristics. Collectively, these findings suggested that STAT3 gene polymorphism (rs4769793) was associated with the susceptibility as well as poor differentiation and parametrial invasion of cervical cancer in Chinese women.

SNP

10.1089/dna.2010.1179

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Citations (30)

Transvaginal natural Orifical transluminal Endoscopy for sacrocolpopexy: A case series report

Heliyon (2023)

Youwen Mei He Li Yan Li Chengling Zhang Qiannan Hou

BackgroundTo describe the surgical technique and operative outcomes of transvaginal natural orifice transluminal endoscopic surgery (V-NOTES) for sacrocolpopexy with or without robotic surgical system in patients with pelvic organ prolapse (POP).MethodsPatients with POP undergoing traditional transvaginal natural orifice transluminal endoscopic surgery (TV-NOTES) or robotic transvaginal natural orifice transluminal endoscopic surgery (RV-NOTES) for sacrocolpopexy performed by one surgeon from Sep 2020 to Jan 2023 in our hospital were included in this study. The baseline demographics and operative outcomes were collected and analyzed. In addition, some surgical skills were presented. The operative outcomes of V-NOTES for sacrocolpopexy performed by three beginners were also presented.ResultsEight patients who underwent TV-NOTES, and two patients who underwent RV-NOTES were included in this study. The mean operative time was 180 ± 49 min, and the estimated blood loss was 107 ± 82 ml for these ten cases. Particularly, the operative time of the two patients who underwent RV-NOTES was 275 and 132 min, while the estimated blood loss (EBL) was 100 and 50 ml respectively. During the follow-up period, no mesh exposure and recurrence were observed. In addition, five cases of TV-NOTES for sacrocolpopexy by beginners were all successfully completed.ConclusionBoth TV-NOTES and RV-NOTES appeared to be feasible and safe for sacrocolpopexy.

10.1016/j.heliyon.2023.e23606

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Citations (3)

How many missed abortions are caused by embryonic chromosomal abnormalities and what are their risk factors?

Frontiers in Genetics (2023)

Xin Li Han Kang Huifeng Yin Tianjiao Liu Qiannan Hou

Introduction: Though embryonic chromosome abnormalities have been reported to be the most common cause of missed abortions, previous studies have mainly focused on embryonic chromosome abnormalities of missed abortions, with very few studies reporting that of non-missed abortion. Without chromosome studies of normal abortion samples, it is impossible to determine the risk factors of embryo chromosome abnormalities and missed abortion. This study aimed to investigate the maternal and embryonic chromosome characteristics of missed and non-missed abortion, to clarify the questions that how many missed abortions are caused by embryonic chromosomal abnormalities and what are their risk factors. Material and methods: This study was conducted on 131 women with missed or non-missed abortion from the Longitudinal Missed Abortion Study (LoMAS). Logistic regression analysis was used to identify the association between maternal covariates and embryonic chromosomal abnormalities and missed abortions. Data on the characteristics of women with abortions were collected. Results: The embryonic chromosome abnormality rate was only 3.9% in non-missed abortion embryos, while it was 64.8% in missed-abortion embryos. Assisted reproductive technology and prior missed abortions increased the risk of embryonic chromosome abnormalities by 1.637 (95% CI: 1.573, 4.346. p = 0.010) and 3.111 (95% CI: 1.809, 7.439. ( p < 0.001) times, respectively. In addition, as the age increased by 1 year, the risk of embryonic chromosome abnormality increased by 14.4% (OR: 1.144, 95% CI: 1.030, 1.272. p = 0.012). Moreover, advanced age may lead to different distributions of chromosomal abnormality types. Conclusion: Nearly two-thirds of missed abortions are caused by embryonic chromosomal abnormalities. Moreover, advanced age, assisted reproductive technology, and prior missed abortions increase the risk of embryonic chromosomal abnormalities.

Chromosome abnormality

Abnormality

Products of conception

10.3389/fgene.2022.1058261

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Citations (3)

Retroperitoneal sentinel lymph node biopsy by transvaginal natural orifice transluminal endoscopic surgery in early stage endometrial cancer: a video

Gynecology and Pelvic Medicine (2023)

Yan Li He Li Qiannan Hou Qiang Zhang Dingqian Gu

10.21037/gpm-23-4

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Updated Progress of Interleukin-17 in Gynecological Tumors

Chung-Hua Fu Ch'an K'o Tsa Chih (2010)

Wenjie Qing Sha Lv Qiannan Hou

Interleukin (IL)-17 is a pro-inflammatory cytokines mainly produced by activated CD4+ T lymphocytes , which involved in the immune response, inflammation and autoimmune diseases , with biological functions of strong recruitment of neutrophils, promoting a variety of cytokines release inflammatory factors and cell proliferation. Present study found that interleukin-17 is significant in tumor development .This article focus on the relationships among interleukin-17 and ovarian cancer, cervical cancer, choriocarcinoma and other gynecological tumors. Key words: interleukin (IL)-17; T helper cell; cancer

Interleukin 15

10.3877/cma.j.issn.1673-5250.2010.05.020

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