Guadalupe C. Vidal‐Cantú

Center for Research and Advanced Studies of the National Polytechnic Institute

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Vinicio Granados‐Soto

Center for Research and Advanced Studies of the National Polytechnic Institute

Héctor Isaac Rocha‐González

Instituto Politécnico Nacional

Rodolfo Delgado‐Lezama

Center for Research and Advanced Studies of the National Polytechnic Institute

Claudia Cervantes‐Durán

Universidad Nacional Autónoma de México

Gabriela Castañeda‐Corral

Universidad Autónoma del Estado de Morelos

Paulino Barragán‐Iglesias

The University of Texas at Dallas

Jorge Baruch Pineda-Farías

University of Pittsburgh

Mariana Bravo‐Hernández

University of California, San Diego

Janet Murbartián

Center for Research and Advanced Studies of the National Polytechnic Institute

Gerardo Reyes‐García

Instituto Politécnico Nacional

Cooperative Institutions

Center for Research and Advanced Studies of the National Polytechnic Institute

Instituto Politécnico Nacional

Universidad Nacional Autónoma de México

Centro de Investigación en Materiales Avanzados

Instituto Nacional de Neurología y Neurocirugía

Mexican Social Security Institute

Centro Medico Nacional Siglo XXI

Hospital de Especialidades

Tecnológico Nacional de México

Autonomous University of San Luis Potosí

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Pharmacy and Pharmacology Communications (1996)

Vinicio Granados‐Soto Guadalupe C. Vidal‐Cantú Francisco Javier Flores‐Murrieta

Some non-steroidal anti-inflammatory drugs (NSAIDs) exhibit sex differences in their pharmacokinetics or pharmacodynamics; pharmacokinetic studies of tolmetin, a potent NSAID used for relief of moderate pain in rheumatoid arthritis, have hitherto been carried out only in males. Here, the pharmacokinetics of tolmetin was studied after an oral administration of 10 mg kg−1 of tolmetin sodium in both male and female Wistar rats. Blood samples were obtained at selected times during 4 h after medication, and tolmetin concentrations were determined by high-performance liquid chromatography. After administration of tolmetin, blood concentrations increased rapidly, reaching the maximal concentration in about 0.3 h in both male and female rats. Then, blood concentrations decayed with a significantly different terminal half-life between male and female rats. In males a half-life of about 0.9 h was observed, whereas in females it was about 3.3 h. The area under the tolmetin blood concentration-time curve for female rats was also significantly higher man that of male rats. These results strongly suggest a sex-related difference in the pharmacokinetics of tolmetin and could reflect differences in isoenzymes of cytochrome P450 that metabolize tolmetin.

Pharmacodynamics

Half-life

10.1111/j.2042-7158.1996.tb00746.x

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Citations (1)

Spinal 5-HT5A receptors mediate 5-HT-induced antinociception in several pain models in rats

Pharmacology Biochemistry and Behavior (2014)

Enriqueta Muñoz‐Islas Guadalupe C. Vidal‐Cantú Mariana Bravo‐Hernández Claudia Cervantes‐Durán Geovanna Nallely Quiñonez‐Bastidas

Dorsal root ganglion

Capsaicin

10.1016/j.pbb.2014.02.001

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Citations (39)

Hypothalamic A11 Nuclei Regulate the Circadian Rhythm of Spinal Mechanonociception through Dopamine Receptors and Clock Gene Expression

Life (2022)

Celia Piña-Leyva Manuel Lara-Lozano Marina Rodríguez-Sánchez Guadalupe C. Vidal‐Cantú Ericka Barrientos Zavalza

Several types of sensory perception have circadian rhythms. The spinal cord can be considered a center for controlling circadian rhythms by changing clock gene expression. However, to date, it is not known if mechanonociception itself has a circadian rhythm. The hypothalamic A11 area represents the primary source of dopamine (DA) in the spinal cord and has been found to be involved in clock gene expression and circadian rhythmicity. Here, we investigate if the paw withdrawal threshold (PWT) has a circadian rhythm, as well as the role of the dopaminergic A11 nucleus, DA, and DA receptors (DR) in the PWT circadian rhythm and if they modify clock gene expression in the lumbar spinal cord. Naïve rats showed a circadian rhythm of the PWT of almost 24 h, beginning during the night-day interphase and peaking at 14.63 h. Similarly, DA and DOPAC's spinal contents increased at dusk and reached their maximum contents at noon. The injection of 6-hydroxydopamine (6-OHDA) into the A11 nucleus completely abolished the circadian rhythm of the PWT, reduced DA tissue content in the lumbar spinal cord, and induced tactile allodynia. Likewise, the repeated intrathecal administration of D1-like and D2-like DA receptor antagonists blunted the circadian rhythm of PWT. 6-OHDA reduced the expression of Clock and Per1 and increased Per2 gene expression during the day. In contrast, 6-OHDA diminished Clock, Bmal, Per1, Per2, Per3, Cry1, and Cry2 at night. The repeated intrathecal administration of the D1-like antagonist (SCH-23390) reduced clock genes throughout the day (Clock and Per2) and throughout the night (Clock, Per2 and Cry1), whereas it increased Bmal and Per1 throughout the day. In contrast, the intrathecal injection of the D2 receptor antagonists (L-741,626) increased the clock genes Bmal, Per2, and Per3 and decreased Per1 throughout the day. This study provides evidence that the circadian rhythm of the PWT results from the descending dopaminergic modulation of spinal clock genes induced by the differential activation of spinal DR.

PER2

PER1

10.3390/life12091411

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Citations (3)

The role of spinal cord extrasynaptic α ₅ GABA _A receptors in chronic pain

Physiological Reports (2021)

Rodolfo Delgado‐Lezama Mariana Bravo‐Hernández Úrzula Franco‐Enzástiga Yarim Elideth De la Luz-Cuellar Nara S. Alvarado‐Cervantes

Chronic pain is an incapacitating condition that affects a large population worldwide. Until now, there is no drug treatment to relieve it. The impairment of GABAergic inhibition mediated by GABA

10.14814/phy2.14984

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Citations (12)

Role of spinal 5-HT 2 receptors subtypes in formalin-induced long-lasting hypersensitivity

Pharmacological Reports (2015)

Claudia Cervantes‐Durán Guadalupe C. Vidal‐Cantú Beatriz Godínez‐Chaparro Vinicio Granados‐Soto

Pharmacotherapy

Hypersensitivity reaction

10.1016/j.pharep.2015.11.009

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Citations (20)

B vitamins increase the anti-hyperalgesic effect of diclofenac in the rat.

PubMed (2002)

Gerardo Reyes‐García Roberto Medina‐Santillán Flavio Terán‐Rosales Carlos Castillo‐Henkel Guadalupe C. Vidal‐Cantú

B vitamins have been reported to be clinically useful alone or combined with non-steroidal anti-inflammatory drugs (NSAIDs) in some painful disorders such as polyneuropathy [1], neuritis [2], painful vertebral syndrome [3] or rheumatic diseases [4]. There is evidence that B vitamins are able to increase the antinociceptive activity of diclofenac in animals [5,6]. In humans, B vitamin preparations have been extensively used as an analgesic adjuvant combined with diclofenac for the treatment of acute lumbar vertebral pain [3,7]. However, as some negative results have also been reported [8-10], the adjuvant properties of the B vitamins complex are not completely established. In the present study, we evaluated the analgesic activity of diclofenac alone and combined with the B vitamins complex (B1, B6 and B12) in the thermal hyperalgesia test.

Diclofenac

B vitamins

Vitamin b

Antipyretic

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Citations (12)

Role of 5-HT5A and 5-HT1B/1D receptors in the antinociception produced by ergotamine and valerenic acid in the rat formalin test

European Journal of Pharmacology (2016)

Guadalupe C. Vidal‐Cantú Mildred Jiménez-Hernández Héctor Isaac Rocha-González Carlos M. Villalón Vinicio Granados‐Soto

Methysergide

Ergotamine