Maria Zolindaki

General Hospital of Nikea

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Lοukianos S. Rallidis

National and Kapodistrian University of Athens

Nikolaos Dagres

Charité - Universitätsmedizin Berlin

Christos Kotakos

Leeds Teaching Hospitals NHS Trust

ΑΚ

Ανδρέας Κατσιμάρδος

University General Hospital Attikon

Maria Anastasiou‐Nana

Chelsea and Westminster Hospital

Aggeliki H. Velissaridou

General Hospital of Nikea

Christos Varounis

National and Kapodistrian University of Athens

Dimitrios Th. Kremastinos

National and Kapodistrian University of Athens

Alexandros Drosatos

University General Hospital Attikon

John Lekakis

National and Kapodistrian University of Athens

Cooperative Institutions

University General Hospital Attikon

National and Kapodistrian University of Athens

General Hospital of Nikea

Istituti di Ricovero e Cura a Carattere Scientifico

Onassis Cardiac Surgery Center

Aichi Medical University

University of Florence

Laiko General Hospital of Athens

Policlinico San Matteo Fondazione

Evangelismos Hospital

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Letter to the Editor Simvastatin exerts its anti-inflammatory effect in hypercholesterolaemic patients by decreasing the serum levels of monocyte chemoattractant protein-1

Lοukianos S. Rallidis E. Hamodraka Katerina Fountoulaki Georgios Moustogiannis Maria Zolindaki

Aim: To assess the effect of simvastatin on serum levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-6, tumor necrosis factor-α, macrophage colony stimulating factor, C-reactive protein and serum amyloid A in hypercholesterolaemic patients without coronary heart disease. Methods: Sixty consecutive hypercholesterolaemic patients were randomly assigned in a 2:1 process to 40 mg of simvastatin daily (n=40) and to hypolipidaemic only diet (n=20) for 3 months. Blood was taken at baseline and at the end of the study and analysed for lipids and inflammatory markers. Results: From the inflammatory markers only MCP-1 was decreased significantly (217.4±48 versus 177±75 pg/ml, p<0.001) after treatment with simvastatin and this reduction was independent of lipid changes. Conclusion: Simvastatin significantly decreases only MCP-1 levels in hypercholesterolaemic patients suggesting that this molecule is probably a sensitive marker to detect the anti-inflammatory effect of simvastatin in blood. © 2007 Elsevier Ireland Ltd. All rights reserved.

Monocyte

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The impact of smoking on long-term outcome of patients with premature (≤35years) ST-segment elevation acute myocardial infarction

American Heart Journal (2014)

Lοukianos S. Rallidis Eleftherios Sakadakis Konstantinos Tympas Christos Varounis Maria Zolindaki

Mace

Reperfusion Therapy

10.1016/j.ahj.2014.12.003

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Homocysteine is an independent predictor of long-term cardiac mortality in patients with stable coronary artery disease in the era of statins

Coronary Artery Disease (2019)

Lοukianos S. Rallidis Nikolaos Kosmas Taxiarchoula Rallidi Georgios Pavlakis Estela Kiouri

Background Homocysteine (Hcy) is considered a risk factor for cardiovascular disease. Objective To explore the long-term prognostic value of Hcy in patients with stable coronary artery disease (CAD) in the era of statins. Methods A total of 876 consecutive patients with stable CAD were recruited and followed up for a median of 6.1 years. Lipids and Hcy levels were measured at baseline. Primary endpoints were cardiac death and secondary endpoints were hospitalizations for acute coronary syndrome, myocardial revascularization, arrhythmic event or ischemic stroke. Results Follow-up data were obtained from 842 patients of whom 70 had a cardiac death (8.3%), while 258 (30.6%) met the secondary endpoints. Seven hundred four patients (83.6%) were on statins. In univariate Cox regression analysis Hcy predicted the occurrence of cardiac death [hazard ratio: 1.030; 95% confidence interval (CI): 1.018–1.042, P < 0.001] but not the occurrence of secondary endpoints (hazard ratio: 1.010; 95% CI: 0.999–1.020, P = 0.081). Hcy remained an independent predictor of cardiac death after adjustment for conventional risk factors, ejection fraction and statin use (hazard ratio: 1.030; 95% CI: 1.017–1.044, P < 0.001). Patients in the highest tertile of Hcy levels (>14.1 μmol/L) had three times higher risk of cardiac death compared with patients in the lowest tertile (<10.3 μmol/L) (hazard ratio = 3.036, CI: 1.983–4.649, P < 0.001). Conclusion Hcy is an independent predictor of cardiac death in patients with stable CAD in the era of statins.

Clinical endpoint

Hyperhomocysteinemia

Univariate analysis

10.1097/mca.0000000000000800

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Usefulness of elevated levels of soluble vascular cell adhesion molecule-1 in predicting in-hospital prognosis in patients with unstable angina pectoris

The American Journal of Cardiology (2003)

Lοukianos S. Rallidis Helen I. Gika Maria Zolindaki T. Xydas K. Paravolidakis

Unstable angina

Pathophysiology

10.1016/j.amjcard.2003.07.029

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Citations (25)

Low Serum Free Testosterone Association With Cardiovascular Mortality in Men With Stable CAD

Journal of the American College of Cardiology (2018)

Lοukianos S. Rallidis Christos Kotakos Stelios Tsalavoutas Ανδρέας Κατσιμάρδος Alexandros Drosatos

Association (psychology)

Free testosterone

10.1016/j.jacc.2018.08.2189

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High levels of lipoprotein (a) and premature acute coronary syndrome

Atherosclerosis (2017)

Lοukianos S. Rallidis G. Pavlakis Alexandra Foscolou Christos Kotakos Ανδρέας Κατσιμάρδος

Lipoprotein(a)

10.1016/j.atherosclerosis.2017.12.011

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P2683Adiponectin is an independent predictor of long-term cardiac mortality in patients with stable coronary artery disease in the era of statins

European Heart Journal (2018)

Lοukianos S. Rallidis Christos Kotakos Ανδρέας Κατσιμάρδος Alexandros Drosatos Maria Zolindaki

10.1093/eurheartj/ehy565.p2683

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Poster Session I: Epidemiology and public health

European Journal of Cardiovascular Prevention & Rehabilitation (2010)

Francesco Sofi Francesca Cesari Sandra Fedi George Broze Rosanna Abbate

Topic: Risk factors and risk prediction Objective: The relationship between protein Z levels and thrombosis is controversial.We performed a systematic review and meta-analysis of all the available studies to assess the association between protein Z and vascular thrombotic diseases.Methods: We conducted an electronic literature search through MedLine, Embase, Google Scholar, Web of Science, The Cochrane Library, bibliographies of retrieved articles and abstracts of congresses up to May, 2009.Studies were included if they analysed protein Z levels in patients with vascular thrombotic diseases.Results: After the review process 28 case-control studies (33 cohort of patients) were included in the final analysis.These studies included 4,218 patients with thrombotic diseases as compared to 4,778 controls.The cumulative analysis for all the studies under a fixed-effects model showed that patients with low protein Z levels are at increased risk of occurring a thrombotic event (OR 1.87, 95%CI 1.62-2.15;p<0.00001).By subgrouping studies according to the different type of the disease, low protein Z levels were found to be a significant risk factor for arterial vascular diseases (OR 1.86, 95%CI 1.51-2.27;p<0.00001), and pregnancy complications (OR 3.42, 95%CI 2.51-4.66;p<0.00001) whereas only a limited significance for venous thromboembolic diseases (OR 1.28, 95%CI 1.00-1.65;p¼0.05) was reported.Conclusion: This is the first meta-analysis that attempted to evaluate the role of protein Z on the occurrence of thrombotic events.The present results suggest, in an overall population of more than 4,000 patients, a possible implication for low levels of this coagulatory protein on the pathogenesis of thrombosis. P53

10.1177/17418267100170s204

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SUBOPTIMAL TREATMENT OF LOW DENSITY LIPOPROTEIN CHOLESTEROL IN VERY HIGH RISK PATIENTS WITH STABLE CORONARY HEART DISEASE

Atherosclerosis Supplements (2008)

Lοukianos S. Rallidis Panagiotis Vavoulis Christos Varounis Maria Zolindaki N Rodolakis

Subgroup analysis

10.1016/s1567-5688(08)70951-6

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Citations (1)

PO19-569 HIGH LEVELS OF FIBRINOGEN ARE ASSOCIATED WITH POOR SHORT-TERM PROGNOSIS IN PATIENTS WITH ACUTE ISCHAEMIC STROKE

Atherosclerosis Supplements (2007)

Lοukianos S. Rallidis Maria Zolindaki Michail Vikelis Georgios Moustogiannis G. Liakos

10.1016/s1567-5688(07)71579-9

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