Richard Feichtinger

Technische Universität Braunschweig

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Ralf Schnabel

Technische Universität Braunschweig

Heinke Schnabel

Max Planck Society

Heinke Holzkamp

Technische Universität Braunschweig

Donald G. Moerman

University of British Columbia

Stéphane Flibotte

University of British Columbia

Erica Li-Leger

University of British Columbia

Laurent Molin

Institut NeuroMyoGène

Jörn Kiselev

Fulda University of Applied Sciences

Pierre Gönczy

École Polytechnique Fédérale de Lausanne

J. Bamat

Swiss Group For Clinical Cancer Research

Cooperative Institutions

Max Planck Institute of Biochemistry

Technische Universität Braunschweig

Max Planck Institut für Zellbiologie

Charité - Universitätsmedizin Berlin

University of British Columbia

Fraunhofer Institute for Software and Systems Engineering

University of Zurich

Max Planck Society

European Molecular Biology Laboratory

École Polytechnique Fédérale de Lausanne

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Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans

Nature (2005)

Jason M. Kinchen Juan Cabello Doris Klingele Kelvin Wong Richard Feichtinger

CDC42

Rac GTP-Binding Proteins

Small GTPase

10.1038/nature03263

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Citations (263)

Complexity of Developmental Control: Analysis of Embryonic Cell Lineage Specification in Caenorhabditis elegans Using pes-1 as an Early Marker

Genetics (1999)

Laurent Molin Heinke Schnabel Titus Kaletta Richard Feichtinger Ian A. Hope

Abstract In the early Caenorhabditis elegans embryo five somatic founder cells are born during the first cleavages. The first of these founder cells, named AB, gives rise to 389 of the 558 nuclei present in the hatching larva. Very few genes directly involved in the specification of the AB lineage have been identified so far. Here we describe a screen of a large collection of maternal-effect embryonic lethal mutations for their effect on the early expression of a pes-1::lacZ fusion gene. This fusion gene is expressed in a characteristic pattern in 14 of the 32 AB descendants present shortly after the initiation of gastrulation. Of the 37 mutations in 36 genes suspected to be required specifically during development, 12 alter the expression of the pes-1::lacZ marker construct. The gene expression pattern alterations are of four types: reduction of expression, variable expression, ectopic expression in addition to the normal pattern, and reduction of the normal pattern together with ectopic expression. We estimate that ∼100 maternal functions are required to establish the pes-1 expression pattern in the early embryo.

Ectopic expression

Caenorhabditis

Lineage (genetic)

10.1093/genetics/151.1.131

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Citations (11)

Identification of essential genes in Caenorhabditis elegans through whole-genome sequencing of legacy mutant collections

G3 Genes Genomes Genetics (2021)

Erica Li-Leger Richard Feichtinger Stéphane Flibotte Heinke Holzkamp Ralf Schnabel

Abstract It has been estimated that 15%–30% of the ∼20,000 genes in C. elegans are essential, yet many of these genes remain to be identified or characterized. With the goal of identifying unknown essential genes, we performed whole-genome sequencing on complementation pairs from legacy collections of maternal-effect lethal and sterile mutants. This approach uncovered maternal genes required for embryonic development and genes with apparent sperm-specific functions. In total, 58 putative essential genes were identified on chromosomes III–V, of which 52 genes are represented by novel alleles in this collection. Of these 52 genes, 19 (40 alleles) were selected for further functional characterization. The terminal phenotypes of embryos were examined, revealing defects in cell division, morphogenesis, and osmotic integrity of the eggshell. Mating assays with wild-type males revealed previously unknown male-expressed genes required for fertilization and embryonic development. The result of this study is a catalog of mutant alleles in essential genes that will serve as a resource to guide further study toward a more complete understanding of this important model organism. As many genes and developmental pathways in C. elegans are conserved and essential genes are often linked to human disease, uncovering the function of these genes may also provide insight to further our understanding of human biology.

Model Organism

Lethal allele

Caenorhabditis

10.1093/g3journal/jkab328

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Citations (8)

SmartSenior’s Interactive Trainer - Development of an Interactive System for a Home-Based Fall-Prevention Training for Elderly People

Advanced technologies and societal change (2012)

Michael John Stefan Klose Gerd Kock Michael Jendreck Richard Feichtinger

Trainer

10.1007/978-3-642-27491-6_22

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Citations (11)

mex-1 and the general partitioning of cell fate in the earlyC. elegans embryo

Mechanisms of Development (1996)

Ralf Schnabel Christiane Weigner Harald Hutter Richard Feichtinger Heinke Schnabel

Blastomere

Cell fate determination

Lineage (genetic)

Polarity (international relations)

10.1016/0925-4773(95)00466-1

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Citations (41)

Identification of essential genes in Caenorhabditis elegans through whole genome sequencing of legacy mutant collections

bioRxiv (Cold Spring Harbor Laboratory) (2021)

Erica Li-Leger Richard Feichtinger Stéphane Flibotte Heinke Holzkamp Ralf Schnabel

ABSTRACT It has been estimated that 15-30% of the ∼20,000 genes in C. elegans are essential, yet many of these genes remain to be identified or characterized. With the goal of identifying unknown essential genes, we performed whole genome sequencing on complementation pairs from legacy collections of maternal-effect lethal and sterile mutants. This approach uncovered maternal genes required for embryonic development and genes with putative sperm-specific functions. In total, 58 essential genes were identified on chromosomes III, IV, and V, of which 49 genes are represented by novel alleles in this collection. Of these 49 genes, 19 (40 alleles) were selected for further functional characterization. The terminal phenotypes of embryos were examined, revealing defects in cell division, morphogenesis, and osmotic integrity of the eggshell. Mating assays with wild-type males revealed previously unknown male-expressed genes required for fertilization and embryonic development. The result of this study is a catalogue of mutant alleles in essential genes that will serve as a resource to guide further study toward a more complete understanding of this important model organism. As many genes and developmental pathways in C. elegans are conserved and essential genes are often linked to human disease, uncovering the function of these genes may also provide insight to further our understanding of human biology.

Lethal allele

Model Organism

Caenorhabditis

10.1101/2021.06.16.448744

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Citations (0)

Centriolar SAS-5 is required for centrosome duplication in C. elegans

Nature Cell Biology (2004)

Marie Delattre Sebastian A. Leidel Khursheed A. Wani Karine Baumer J. Bamat

Centriole

Centrosome cycle

Microtubule organizing center

Basal body

Spindle pole body

10.1038/ncb1146

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Citations (159)