Xinyue Niu

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2fmzxz

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Distinct reactivities of ortho-chalcone-substituted organophosphines with activated alkynes: skeletal editing or periphery modification

Green Chemistry (2023)

Chaoyang Li Xinyue Niu Wan Xu Zhanwei Bu Wenjing Zhang

We report a substrate-controlled diversity-oriented synthetic strategy that can precisely convert ortho -chalcone-substituted organophosphines into other synthetically challenging organophosphorus compounds via skeletal editing or periphery modification.

Chalcone

10.1039/d3gc03165a

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Citations (4)

Organophosphine as an Alkyl Transfer Shuttle for the Direct β-Alkylation of Chalcones Using Alkyl Halides

The Journal of Organic Chemistry (2022)

Lijie Gu Chaoyang Li Xinyue Niu Xiong‐Li Liu Zhanwei Bu

We report an efficient alkyl transfer strategy for the direct β-alkylation of chalcones using commercially available alkyl bromides as alkyl reagents. In this transformation, the ortho-phosphanyl substituent in the chalcones is crucial for controlling their reactivity and selectivity. It also serves as a reliable alkyl transfer shuttle to transform electrophilic alkyl bromides into nucleophilic alkyl species in the form of quaternary phosphonium salts and transfer the alkyl group effectively to the β-position of the chalcones. This alkyl transfer strategy can be further extended to the alkenylation of ortho-phosphanyl benzaldehydes to assemble functionalized polyenes.

Phosphonium

Beta-Hydride elimination

10.1021/acs.joc.2c02505

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Citations (5)

CCDC 2254846: Experimental Crystal Structure Determination

The Cambridge Structural Database (2024)

Xinyue Niu Chaoyang Li Congcong Zhang Zhanwei Bu Yan Xie

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2fpbzg

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Diastereoselective construction of bridged piperidines through an interrupted dearomative reduction

Chemical Communications (2022)

Huabin Han Lele Wang Xinyue Niu Chaoyang Li Yuanqing Xu

An interrupted dearomative reduction strategy was developed to transform planar chalcone-based pyridinium salts into structurally intriguing bridged piperidines in a completely regio- and diastereoselective manner. This reaction proceeded successfully by using cheap and easily accessible NaBH4 as the reductant under mild conditions without exclusion of oxygen or use of special equipment.

10.1039/d2cc02225g

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Citations (9)

Water-controlled skeletal editing or peripheral modification of ortho-chalcone-substituted organophosphines

Green Synthesis and Catalysis (2024)

Xinyue Niu Chaoyang Li Congcong Zhang Zhanwei Bu Yan Xie

Skeletal editing of organophosphines is highly challenging owing to the high P-C bond dissociation energy. Herein, we report an efficient catalyst- and additive-free skeletal editing strategy to transform easily accessible ortho-chalcone based organophosphines into new and complex phosphine oxides, that are unattainable by conventional methods. Water is indispensable to this transformation and serves as the oxygen source to cleave P-C bonds. Interestingly, it is possible to achieve the peripheral modification of organophosphines into phosphonium salts in the absence of water. This water-controlled skeletal editing or peripheral modification strategy is embedded with the merits of high bond- and ring-forming efficiency and complete regio-, chemo- and stereoselectivity.

Chalcone

Phosphonium

10.1016/j.gresc.2023.12.003

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Citations (1)

CCDC 2194959: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Chaoyang Li Xinyue Niu Wan Xu Zhanwei Bu Wenjing Zhang

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2cp148

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CCDC 2162995: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Huabin Han Lele Wang Xinyue Niu Chaoyang Li Yuanqing Xu

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2bls1s

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CCDC 2168123: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Yusheng Zhao Xinyue Niu Hong Yang Jing Yang Zhizeng Wang

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2bs3gq

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A combination of polarity reversal, Diels–Alder cycloaddition and skeletal remodeling to access pyridine-fused nitrones

Chemical Communications (2022)

Huabin Han Chaoyang Li Xinyue Niu Yuxia Wang Wenjing Zhang

An unprecedented cascade strategy consisting of polarity reversal, normal electron-demand Diels-Alder cycloaddition and skeletal remodeling was developed to construct novel pyridine-fused nitrones in up to 82% yield. The key to the success was the umpolung process, which transformed the electron-deficient 3-nitropyridinium ring into a reactive, π-extended cyclic nitroalkene, serving as a rarely reported hetero-diene to participate in normal Diels-Alder cycloadditions.

Diels–Alder reaction

Umpolung

Polarity (international relations)

Diene

10.1039/d2cc00155a

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Citations (11)

Papers

Citation

H-Index

i-10 index

Papers

Citation

H-Index

i-10 index