Two patients with idiopathic Fanconi syndrome and glucose intolerance were studied from a metabolic perspective. They had fasting hyperglycemia, massive glucosuria, insulinopenia, ketosis, and elevated serum free fatty acids. There was a markedly blunted insulin secretory response to glucagon, tolbutamide, glucose, and arginine. One patient had the findings of diabetic retinopathy and a sensory neuropathy. Neither patient could convert galactose to glucose, but they did not have galactosemia. As a result of these studies, and previous reports in which similar changes were noted, we conclude that diabetes mellitus may occur in patients who have had idiopathic Fanconi syndrome for many years.
Journal Article Viral Infection of Human Fetal Islets of Langerhans: Replication of Human Cytomegalovirus in Cultured Human Fetal Pancreatic Islets Get access Kei Numazaki, M.D., Ph.D., Kei Numazaki, M.D., Ph.D. Department of Microbiology, Montreal Children’s Hospital and McGill University, and Laboratory of Biochemical Genetics, McGill University, Montreal Children’s Hospital Research Institute, and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada Address reprint requests to Dr. Wainberg: Lady Davis Institute, Jewish General Hospital, 3755 Chemin Cote Ste-Catherine, Montreal, Quebec H3T 1E2, Canada. Search for other works by this author on: Oxford Academic Google Scholar Hy Goldman, M.D., Hy Goldman, M.D. Department of Microbiology, Montreal Children’s Hospital and McGill University, and Laboratory of Biochemical Genetics, McGill University, Montreal Children’s Hospital Research Institute, and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar Ines Wong, RT, Ines Wong, RT Department of Microbiology, Montreal Children’s Hospital and McGill University, and Laboratory of Biochemical Genetics, McGill University, Montreal Children’s Hospital Research Institute, and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar Mark A. Wainberg, Ph.D. Mark A. Wainberg, Ph.D. Department of Microbiology, Montreal Children’s Hospital and McGill University, and Laboratory of Biochemical Genetics, McGill University, Montreal Children’s Hospital Research Institute, and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 90, Issue 1, 1 July 1988, Pages 52–57, https://doi.org/10.1093/ajcp/90.1.52 Published: 01 July 1988 Article history Received: 14 September 1987 Accepted: 30 November 1987 Published: 01 July 1988
Abstract Eight children with X-linked hypophosphatemia (three girls and five boys between three and 15 years of age) were treated for a total of 11,297 patient days with an inorganic phosphate salt...
Abstract A tissue culture system for the growth of human fetal and infantile thymic epithelial (TE) cells has been established and characterized. We have investigated the effects of infection of these cells by human cytomegalovirus (CMV), measles virus, and human immunodeficiency virus type‐1 (HIV‐1). In the case of CMV, morphological changes were apparent by 2–4 days after viral inoculation of infantile TE cells. CMV‐related antigens were detected by immunofluorescence after 12 days, and progeny infectious CMV was recovered from culture media after 18 days. Following infection by measles virus, distinctive, multinucleated giant TE cells appeared in both cultures of fetal and infantile TE cells. Measles virus‐inoculated TE cells displayed an altered phenotype, as revealed by reaction with monoclonal antibodies with specificity for a variety of TE markers. Finally, infection of TE cells by HIV‐1 resulted in cellular disarrangement, increased numbers of Hassall's corpuscles, and multinucleated giant cells. An increase in the number of cells reactive with monoclonal antibodies, specific for Hassall's corpuscles, was observed in the case of cells infected by either measles virus or HIV‐1. These findings suggest that a variety of different viruses can successfully infect thymic epithelial tissue. Because of the important role of the thymus in development of the immune system, it is reasonable to conclude that viral infection of thymic tissue might play an important role in virus‐mediated suppression of immune responsiveness.
