Sheng Kang

Shanghai East Hospital

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Yuejin Yang

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhongmin Liu

Shanghai East Hospital

Yi Tian

Shanghai Chest Hospital

Runlin Gao

Chinese Academy of Medical Sciences & Peking Union Medical College

Yutong Cheng

Beijing Anzhen Hospital

Shi-jie You

Chinese Academy of Medical Sciences & Peking Union Medical College

Jue Chen

Rockefeller University

Lieying Fan

Tongji University

Yongjian Wu

Chinese Academy of Medical Sciences & Peking Union Medical College

Jun Dai

Zhejiang Hospital

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai East Hospital

Fu Wai Hospital

Tongji University

Peking Union Medical College Hospital

State Key Laboratory of Cardiovascular Disease

Shanghai Jiao Tong University

Capital Medical University

Peking University

Sun Yat-sen University

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Increased glycated albumin and decreased esRAGE levels are related to angiographic severity and extent of coronary artery disease in patients with type 2 diabetes

Atherosclerosis (2009)

Lin Lu Pu Li Qi Zhang Ling Jie Wang Sheng Kang

10.1016/j.atherosclerosis.2008.12.045

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Citations (77)

Effects of GRK5 and ADRB1 polymorphisms influence on systolic heart failure

Journal of Translational Medicine (2015)

Sheng Kang Xuan Hong Ruan Chang-wu Ping Yu Shanshan Yu

G-protein receptor kinase 5 (GRK5) Gln41 > Leu and β1-adrenergic receptor (ADRB1) Arg389 > Gly polymorphisms presented the different distribution of genotype frequencies between Caucasian American and African American, and produced the difference in β-blocker treatment effect among them with systolic heart failure (SHF). This study sought to identify the distributed characteristics of these variant genotypes in Chinese population, and influence of GRK5 and ADRB1 polymorphisms on SHF morbidity and β-blocker treatment effect in patients with SHF. This study was based on cross-sectional survey data. 1794 and 1718 subjects' ADRB1 and GRK5 gene sequencing (sanger method) data were achieved respectively. Blood samples collection, clinical laboratory detection, electrocardiogram and echocardiography examinations were performed. Medication usage was confirmed at in-hospital visits or the questionnaire by personal interview. GRK5 Leu41Leu genotype was not found in our Chinese population. In non-SHF population, allele frequencies of GRK5 Gln41 and Leu41 were 2782 (0.992) and 22 (0.008) (Hardy-Weinberg equilibrium test χ2 = 0.088, P = 0.767), and allele frequencies of ADRB1 Arg389 and Gly389 were 2127 (0.715) and 849 (0.285) (χ2 = 0.272, P = 0.602). In SHF patients, allele frequencies of Gln41 and Leu41 were 446 (0.991) and 4 (0.009) (χ2 = 0.018, P = 0.893), and allele frequencies of Arg389 and Gly389 were 331 (0.726) and 125 (0.274) (χ2 = 1.892, P = 0.169). Further in logistic regression model, these ADRB1 and GRK5 variants were not significantly independently associated with the risk of SHF morbidity. Those carrying genotype ADRB1 Gly389Gly did not reduce significantly the risk of SHF morbidity after β-blocker therapy. GRK5 Leu41Leu genotype was not found in our Chinese population, neither ADRB1 nor GRK5 variants presented independently associated with the risk of SHF morbidity, most ADRB1 and GRK5 polymorphisms did decrease significantly the risk of SHF morbidity after β-blocker therapy except for those carrying genotype ADRB1 Gly389Gly.

10.1186/s12967-015-0402-7

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Citations (14)

Effects of statin therapy on the progression of carotid atherosclerosis: a systematic review and meta-analysis

Atherosclerosis (2004)

Sheng Kang Yangfeng Wu Xian Li

Jadad scale

10.1016/j.atherosclerosis.2004.08.005

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Citations (126)

Relationship of High-Sensitivity C-Reactive Protein Concentrations and Systolic Heart Failure

Current Vascular Pharmacology (2017)

Sheng Kang Lieying Fan Ming Chen Jue Li Zhongmin Liu

Excessive activated proinflammatory cytokines may promote extracellular matrix alterations which induce adverse left ventricular remodeling in systolic heart failure (SHF). We sought to identify whether high-sensitivity C-reactive protein (hsCRP) levels were independently associated with SHF.In our retrospective case-control study, 2236 subjects were included, and 260 patients had SHF. Blood sample collection, clinical laboratory tests, electrocardiogram and echocardiography examinations were performed. The questionnaires were completed by professional interviews.In 2236 subjects, the prevalence rate of SHF were 1.7, 1.8, 8.4 and 32.6% between hsCRP concentrations (<1 mg/L, ≥1 to <3 mg/L, ≥3 to <10 mg/L and ≥10 mg/L, respectively) (p=0.000). hsCRP concentrations (<1 mg/L, ≥1 to <3 mg/L, ≥3 to <10 mg/L and ≥10 mg/L) were associated in a linear trend with N-terminal pro-brain natriuretic peptide (NT-proBNP, p=0.000) and left ventricular ejection fraction (LVEF, p=0.000). hsCRP was also significantly related to NT-proBNP, LVEF and SHF (r=0.232, p=0.000; r=-0.358, p=0.000 and r=0.413, p=0.000, respectively). In logistic regression model, after adjusting for heart failure risk factors, compared with the low concentration of hsCRP (<1 mg/L), the high concentration of hsCRP (≥10 mg/L) was significantly independently associated with SHF (odds ratio = 10.78 [1.303 to 89.10], p=0.027).Low to high concentration of hsCRP showed a linear trend association with SHF. A high concentration of hsCRP was independently associated with SHF.

10.2174/1570161115666170404121619

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Citations (19)

Angiogenesis and Vasculogenesis at 7-Day of Reperfused Acute Myocardial Infarction

Nature Precedings (2008)

Sheng Kang Yuejin Yang Qingzhi Wang Yue Li Yi Tian

Abstract Objectives This study is to investigate the angiogenesis and vasculogenesis at the first week of reperfused acute myocardial infarction (AMI).Methods 16 of mini-swines (20 to 30 Kg) were randomly assigned to the sham-operated group and the AMI group. The acute myocardial infarction and reperfusion model was created and the pig tail catheter was performed to monitor hemodynamics before left anterior descending coronary artery (LAD) occlusion, 90 min of LAD occlusion and 120 min of LAD reperfusion. Pathologic myocardial tissue was collected at 7-day of LAD reperfusion and further assessed by immunochemistry, dual immunochemistry, in-situ hybridization, real-time quantitative polymerase chain reaction and western blot. Results The infarcted area had higher FLK1 mRNA expression than sham-operated area and the normal area (all P<0.05), and the infarcted and marginal areas showed higher CD146 protein expression than the sham-operated area (all P<0.05), but the microvessel density (CD31 positive expression of microvessels/HP) was not significantly different between the infarcted area and the sham-operated area (8.92±3.05 vs 6.43±1.54) at 7-day of reperfused acute myocardial infarction (P>0.05). Conclusions FLK1 and CD146 expression significantly increase in the infarcted and marginal areas, and the microvessel density is not significantly different between the infarcted area and the sham-operated area, suggesting that angiogenesis and vasculogenesis in the infarcted area appear to high frequency of increase in 7-day of reperfused myocardial infarction.

Vasculogenesis

CD31

Arteriogenesis

Microvessel

10.1038/npre.2008.2066.1

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Characteristics of Confirmed Novel Coronavirus Disease Cases at Shanghai East Hospital: A Retrospective Single-Center Study

Research Square (Research Square) (2020)

Chenghui Fan Lihong Qu Zhongliang Guo Jianhua Zhang Jun Wang

Abstract Background: Since the outbreak of the novel coronavirus disease (COVID-19), the fever outpatient clinic has been open in Shanghai East Hospital (SEH). We analyzed the data for all 4,699 patients from SEH and the 27 confirmed COVID-19 cases among them to determine the clinical and epidemiological characteristics of confirmed COVID-19 cases identified in the SEH. Methods: Data were collected for patients who visited the fever outpatient clinic in the SEH between January 23 and April 30, 2020. We compared the characteristics of confirmed cases, including age, occupation, area, symptoms, laboratory results, and computed tomography (CT) scans, by month. Results: By April 30, 4,699 patients had visited the fever outpatient clinic of the SEH; of those, 27 (0.57%) were confirmed COVID-19 cases. Among the confirmed domestic cases identified between January and February, four of five were from Wuhan, Hubei. Following the spread of the epidemic to other parts of the world, all confirmed cases identified in March–April were cases of individuals who were returning from abroad, mainly Chinese students living abroad. Further, all cases were from outside Shanghai, and no local residents were diagnosed in the clinic. Symptoms, laboratory tests, and CT scans were consistent with previous literature reports of positive COVID-19 cases. Conclusions: Given the necessity to control the spread of this epidemic domestically and abroad, the focus of COVID-19 prevention and control has shifted. In Shanghai, measures taken to prevent COVID-19 spread were very successful. Early isolation and quarantine are necessary and effective measures.

Outpatient clinic

Isolation

10.21203/rs.3.rs-33689/v1

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Citations (0)

WITHDRAWN: Low Density Lipoprotein Receptor Related Protein 6-mediated Cardiovascular Diseases and associated signaling pathways

Canadian Journal of Cardiology (2019)

Sheng Kang Jielin Pu

10.1016/j.cjca.2019.05.021

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Comparison of in-hospital and long-term outcomes between a Cypher stent and a Taxus stent in Chinese diabetic patients with coronary artery disease

Chinese Medical Journal (2007)

Yuejin Yang Bo Xu Sheng Kang Wei-dong Pei Ji‐Lin Chen

Background The sirolimus and paclitaxel distribution patterns and tissue residence time may be modified in atherosclerotic lesions for patients with diabetes, and the biological mechanisms of action for these agents differ significantly. Previous clinical trials have yielded discrepant results of major adverse cardiac events and restenosis between a sirolimus-eluting stent and a paclitaxel-eluting stent in coronary artery disease. Therefore, this study was conduced to compare in-hospital and long-term clinical outcomes between patients receiving sirolimus-eluting stent (Cypher or Cypher Select stent) and paclitaxel-eluting stent (Taxus Express stent) after percutaneous intervention (PCI) in Chinese patients with diabetes. Methods One hundred and sixty-four consecutive diabetic patients underwent PCI in Fuwai Hospital from April 2004 to December 2004. Of them, 101 patients received Cypher or Cypher Select stents (Cypher group, 145 stents) and 63 patients received Taxus Express stents (Taxus group, 129 stents). Repeat coronary angiography was performed at 6-month and clinical outcomes were evaluated at 1- and 3-year follow-up. Stent thrombosis was classified according to Academic Research Consortium (ARC). Results The two groups did not differ significantly with respect to cardiac death, recurrent myocardial infarction (re-MI), target vessel revascularization (TVR) and occurrence of major adverse cardiac events (MACE). And the MACE-free cumulative survival at 1- and 3-year follow-up and early, late and very late thrombosis rates were also similar in the two groups (all P>0.05). There was a trend favoring PES over SES with regard to reducing cardiac death (0 vs 2.0%, P=0.524), re-MI (0 vs 2.0%, P=0.524), the composite of the cardiac death and re-MI (0 vs 4.0%, P=0.299) and very late thrombosis (0 vs 3.0%, P=0.295) between 1-year and 3-year follow-up. Conclusion The study indicates that PCI with either Cypher or Taxus stents is associated with similar efficacy and safety in the small population of Chinese diabetic patients during long-term follow-up.

Mace

Sirolimus

10.1097/00029330-200711010-00003

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Citations (5)

Expressions of eNOS3 and Ve-Cadherin in Microvascular Endothelium at 7-Day of Reperfused Acute Myocardial Infarction

Cardiovascular & Haematological Disorders - Drug Targets (2009)

Sheng Kang Yue-Jin Yang Qingzhi Wang Yue Li Yi Tian

Objective: To investigate the expressions of eNOS3 and Ve-cadherin at the first week of reperfused acute myocardial infarction (AMI). Methods:16 of mini-swines (20 to 30 Kg) were randomly assigned to the sham-operated group and the AMI group. Pathologic myocardial tissue was collected at 7-day of LAD reperfusion and assessed by immunofluorescence and laser co-focus microscope scan, in-situ hybridization, real-time quantitative polymerase chain reaction and western blot. Results: At 7-day of reperfusion, the eNOS3 mRNA and protein expressions in the infarcted and marginal areas were lower than those in the normal area and sham-operated area (all P < 0.05), similarly the infarcted and marginal areas had lower Ve-cadherin mRNA expression than the normal area and the sham-operated area (all P < 0.05), and Ve-cadherin protein expression was lower in the infarcted area compared with the marginal area, the normal area and the sham-operated area (all P < 0.05). Conclusion: Lowexpressions of eNOS3 and Ve-cadherin in the salvaged sub-healthy microvascular endothelium of infarcted and marginal areas suggest that endothelial system is impaired at 7-day of reperfused acute myocardial infarction.

VE-cadherin

Immunofluorescence

10.2174/187152909788488663

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Citations (3)

Analysis of Type a Personality in Patients with Recurrent Vasovagal Syncope

SSRN Electronic Journal (2022)

Guang Xia Yong Ye Sheng Kang Bo Hu Jielin Pu

Background To analyze the personality of patients with recurrent vasovagal syncope (VVS) and to observe the response to metoprolol succinate in recurrent VVS patients during head-up tilt test (HUTT) with different personality types. Methods Patients with recurrent VVS (at least 2 times) who were admitted to the syncope center of our hospital and healthy subjects matched for age and sex were collected. Questionnaires were used to analyze their personality types. After oral administration of metoprolol succinate daily for 5-7 days, a head-up tilt test (HUTT) was conducted again to compare the efficacy of metoprolol succinate on VVS patients with different personality types. Results One hundred forty-two recurrent VVS patients and 142 healthy people without syncope were enrolled. Behavioral analysis showed that the proportion of type A personality was 76.4% in the recurrent VVS group, which was significantly higher than that of the control group (40.8%, P<0.01). After taking metoprolol succinate, the rate of recurrent syncope during HUTT was 37.8% and 58.5% in VVS patients of type A personality and non-A personality, respectively (all P <0.05). Conclusion The proportion of type A personality in the recurrent VVS group was significantly higher than that of the control group. Metoprolol succinate improves the sensitivity to HUTT in recurrent VVS patients with type A personality.

Vasovagal Syncope

Personality type

10.2139/ssrn.4212239

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Citations (0)