Silvia D. Rohr

European Molecular Biology Laboratory

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Manuel Stemmer

Max Planck Institute for Biological Intelligence

Gáspár Jékely

Heidelberg University

Aleksandra Marconi

University of Cambridge

Jocelyn L.Y. Tang

New York University

Detlev Arendt

European Molecular Biology Laboratory

Laura Schuhmacher

European Molecular Biology Laboratory

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Èlia Benito‐Gutiérrez

University of Cambridge

Giacomo Gattoni

Columbia University

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European Molecular Biology Laboratory

University of Cambridge

Heidelberg University

University College London

European Molecular Biology Laboratory

European Bioinformatics Institute

Max Planck Institute for Biological Intelligence

Max Planck Institute for Intelligent Systems

University of Konstanz

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The dorsoanterior brain of adult amphioxus shares similarities in expression profile and neuronal composition with the vertebrate telencephalon

BMC Biology (2021)

Èlia Benito‐Gutiérrez Giacomo Gattoni Manuel Stemmer Silvia D. Rohr Laura Schuhmacher

The evolutionary origin of the telencephalon, the most anterior part of the vertebrate brain, remains obscure. Since no obvious counterpart to the telencephalon has yet been identified in invertebrate chordates, it is difficult to trace telencephalic origins. One way to identify homologous brain parts between distantly related animal groups is to focus on the combinatorial expression of conserved regionalisation genes that specify brain regions.

10.1186/s12915-021-01045-w

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Patterning of a telencephalon-like region in the adult brain of amphioxus

bioRxiv (Cold Spring Harbor Laboratory) (2018)

Èlia Benito‐Gutiérrez Manuel Stemmer Silvia D. Rohr Laura Schuhmacher Jocelyn L.Y. Tang

ABSTRACT The evolutionary origin of the vertebrate telencephalon remains unsolved. A major challenge has been the identification of homologous brain parts in invertebrate chordates. Here we report evidence for a telencephalic region in the brain of amphioxus, the most basally branching invertebrate chordate. This region is characterised, like its vertebrate counterpart, by the combined expression of the telencephalic markers FoxG1, Emx and Lhx2/9 . It is located at the anterior neural border and dorsal-ventrally patterned, as in vertebrates, by the antagonistic expression of Pax4/6 and Nkx2.1 , and a ventral Hh signal. This part of the brain develops only after metamorphosis via sustained proliferation of neuronal progenitors at the ventricular zone. This is concomitant with a massive expansion of late differentiating neuronal types as revealed by neuropeptide and neurotransmitter profiling. Overall, our results suggest that the adult amphioxus brain shows remarkable similarities to the vertebrate embryonic brain, thus providing a key missing link in understanding the invertebrate-to-vertebrate transition in chordate brain evolution.

Chordate

Ganglionic eminence

Notochord

10.1101/307629

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Citations (12)