Sara Carella

Sapienza University of Rome

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Maria Giuseppina Onesti

Sapienza University of Rome

Paolo Fioramonti

SUNY Upstate Medical University

Nicolò Scuderi

Sapienza University of Rome

Michele Maruccia

University of Bari Aldo Moro

Pasquale Fino

Sapienza University of Rome

Diego Ribuffo

Policlinico Umberto I

Graziano Spinelli

Sapienza University of Rome

N. Scuderi

Policlinico Umberto I

Cinzia Marchese

Sapienza University of Rome

Federico Lo Torto

Policlinico Umberto I

Cooperative Institutions

Ospedali Riuniti di Ancona

109

Sapienza University of Rome

Policlinico Umberto I

Istituti di Ricovero e Cura a Carattere Scientifico

University of Naples Federico II

University of Milan

University of Perugia

Ospedale San Pietro Fatebenefratelli

University of Rome Tor Vergata

University of Bologna

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Rigenase® and Polyhexanide combination for Wounds Treatment: The PMCF Survey

Journal of Surgery (2023)

G. Di Chiara Caliumi Luca Palombi Antonio Gallese Alessandro Scalise

As the sequence of events of impaired wound healing is well characterized, the possibility to identify treatments that are already in the market and that are known to target one or, even better, many of the described molecular events can be taken into account.In this regard, several molecules with different indications have shown beneficial effects in promoting wound healing.Through these molecules, a most recent and effective one is represented by Rigenase ® , a peculiar patented triticum vulgare extract which in association with polyhexanide, an antiseptic that doesn't give any resistance to bacteria, characterizes the Fitostimoline ® Plus formulations.Rigenase ® , consists of a mix of oligosaccharides, having consolidated activities in the wound healing process.Polyhexanide is an antiseptic that has specific activities on bacteria, fungi and some viruses.The Fitostimoline ® Plus formulations are present in the form of gauzes, spray and cream and all represent a valid and safe alternative for the treatment of various type of wounds, including burns, abrasions, ulcers and lesions.In this trial, we evaluated through a survey on a large population of patients, the efficacy and tolerability of the Fitostimoline® Plus formulations considering which one is the eligible product for each specific indication, in order to help the physicians to choose among the various types of these medical devices.

10.29011/2575-9760.001896

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Peripheral Blood Mononuclear Cells

Springer eBooks (2023)

Sara Carella Maria Giuseppina Onesti

10.1007/978-3-031-45453-0_26

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Citations (2)

A clinical case of cutaneous silica granuloma.

PubMed (2014)

Maria Giuseppina Onesti Pasquale Fino Vittoria Amorosi F. Piro Doria Pedace

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The use of Peripheral Blood-Mononuclear Cells in Scleroderma patients: an observational preliminary study

Research Square (Research Square) (2020)

Sara Carella Caterina Rossi Diego Ribuffo Maria Giuseppina Onesti

Abstract Background Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by vasculopathy and excessive production of collagen, which lead to skin and visceral fibrosis. The aim of our study is to assess the potential benefits of peripheral blood mononuclear cells (PB-MNCs) implants in the treatment of clinical manifestations such as mouth impairment, hand disability, digital ulcers and Raynaud’s phenomenon in Scleroderma patients. Methods From February 2016 to May 2019, 10 female patients were enrolled from the outpatient clinic of the Plastic Surgery Unit of Sapienza University of Rome. Parameters evaluated were: patients’ disability, using the Health Assessment Questionnaire (HAQ) disability index (DI) and the scleroderma HAQ (sHAQ); mouth opening capacity, by measuring the maximum interincisal distance and the mouth perimeter; hand mobility, assessed with clinical exam and the Hand Mobility in Scleroderma (HAMIS) scale; Raynaud’s phenomenon, evaluated through nailfold capillaroscopy; digital ulcers, examined through their features and incidence of appearance. SPSS software was used for a simple descriptive statistical analysis performed by the Student's paired t-test. P values less than 0.05 were considered statistically significant. Results The treatment showed a significant improvement of all the parameters evaluated at 1-year follow-up, it was well-tolerated by all the patients and the only complications noticed were small areas of ecchymosis. Conclusions Our results suggest that PB-MNCs injection could represent a treatment option to take into account for SSc patients. The procedure we used is easy and fast to perform, minimally invasive and not-operator dependent. We hope our observational and preliminary study could be considered as a starting point for further research studies.

Scleroderma (fungus)

Systemic scleroderma

Angiology

Outpatient clinic

10.21203/rs.3.rs-53467/v1

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Surgical and Laser Treatment of Sturge-Weber Syndrome

Aesthetic Plastic Surgery (2009)

Maria Giuseppina Onesti Paolo Fioramonti Sara Carella Graziano Spinelli Nicolò Scuderi

Sturge–Weber syndrome

Angiomatosis

Port-wine stain

Laser Treatment

Trigeminal Nerve

10.1007/s00266-009-9327-y

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Citations (5)

Clinical Management of Complications Following Filler Injection

Aesthetic Plastic Surgery (2021)

Sara Carella G Ruggeri Raffaele La Russa Gianpietro Volonnino Paola Frati

Filler (materials)

Erythema

10.1007/s00266-021-02650-4

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A new association between hyaluronic acid and collagenase in wound repair: an open study.

PubMed (2013)

Maria Giuseppina Onesti Paolo Fioramonti Sara Carella Pasquale Fino Valentina Sorvillo

Most ulcers occur with slough and need debridement treatment. Surgical treatment is usually performed but many patients need an additional chemical therapy to promote healing process. This type of wound bed preparation is slower than surgical one, but it is essential in those patients who are not eligible for surgery because of systemic diseases. A collagenase derived from the bacterium Clostridium hisolyticum is the most used.To evaluate the safety and the effectiveness of a new collagenase produced by Vibrio algynoliticum.Forty patients were enrolled and daily treated for five weeks with Bionect Start® ointment. Parameters took into account were fibrin degradation and pain relief. The same team carried out treatment during the study period of five weeks.32 patients achieved a relevant reduction of the ulcer size, an improvement of the wound bed and a reduction of fibrin and exudates. Among of 32, 14 patients presented with a complete healing. Eight patients had mild or no improvements. The patients referred a remarkable pain reduction, 20 out of 40 patients reported a decrease in pain during treatment, 16 patients referred no pain at all and four patients had no significant changes.The application of this product on the lesions promotes vascularized granulation tissue and reduces formation of fibrin and exudate. Furthermore, a macroscopical margins proliferation is highlighted after a short time and an improvement of periwound skin is observed during the treatment period. Bionect Start® allowed easy removal of dressing, less pain for patient, reduction of dressing time.

Granulation tissue

Debridement (dental)

Microbial collagenase

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The effects of COVID-19 pandemic on elective post-bariatric surgery waiting list: a single Plastic Surgery Center investigation

DOAJ (DOAJ: Directory of Open Access Journals) (2020)

G Marruzzo Ugo Redi Luca Patanè Enrico Cavalieri Jacopo Maria Frattaroli

Objective After massive weight loss, patients that meet specific criteria can be inserted in an ad-hoc post-bariatric surgery list in order to be subjected to body contouring procedures. During COVID-19 pandemic, the Italian National Health System has been overwhelmed by the continue load of life-threatening patients that needed medical assistance. Plastic surgery practice enormously scaled back during this period and this fact greatly affected elective procedures waiting lists. The aim of our study is to analyze how the lockdown and its related sanitary policies affected post-bariatric patients' behaviors towards the delay of their procedure. Patients and methods A 7-item questionnaire was administered to all patients. Change in the desire to be subjected to body contouring procedures was recorded. Smoking status, level of training during quarantine and psychological co-morbidities were also evaluated. Results 124 patients completed the questionnaire. Data analysis showed that none of them encountered a decrease of the desire to be subjected to post-bariatric plastic surgery procedures. Conclusions The present study showed that all the patients in the waiting list did not modify their interest in being subjected to post-bariatric surgery procedures, even though the waiting time increased.

Body contouring

Abdominoplasty

Pandemic

Waiting list

Weight Loss Surgery

Elective surgery

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Subcutaneous angioleiomyoma of the nasal tip. Report of a rare case.

PubMed (2012)

Maria Giuseppina Onesti Michele Maruccia Sara Carella Antônio Rossi G. Soda

Angioleiomyoma is a rare benign tumor of smooth muscle origin. It has been reported in many anatomical sites, but it is very rare in the nose. This article describes the case of a 46-year-old woman, with a subcutaneous vascular leiomyoma of the nasal tip. She reported a small painless mass. The skin which was covering it became strongly erythematous at high temperatures, with an annoying increase of the sensitivity. There are no specific imaging techniques capable of characterizing the vascular leiomyoma, however sonography represents an excellent modality for initial evaluation of this kind of lesion. We chose excision with an open rhinoplasty approach for treatment of the lesion. Obvious and disfiguring scars do not remain with this surgical approach. The patient had immediate and complete relief of her symptoms, the aesthetic result is very good and her satisfaction is complete.

Angioleiomyoma

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Paget extramammario: un caso clinico di Paget vulvare

Maria Giuseppina Onesti Paolo Fioramonti Sara Carella Giuseppe Spinelli

Il Paget extrammammario e una patologia rara che generalmente colpisce la popolazione in eta senile. Si puo localizzare prevalentemente al livello della cute in regione ascellare, perineale e perianale, vulvare nelle donne e peniena nell’uomo. Istologicamente e una neoplasia intraepiteliale, caratterizzata dalla presenza delle cellule di Paget come la sua controparte mammaria, che e spesso associata a carcinoma duttale invasivo sottostante ed e generalmente considerata d’origine ghiandolare (ghiandola mammaria sottostante) e/o duttale. Il Paget extramammario, invece, e associato ad un carcinoma invasivo sottostante solo nel 25% dei casi e la sua patogenesi e controversa. Le pazienti con morbo di Paget vulvare sono a rischio per una seconda neoplasia sincrona o metacrona: l’adenocarcinoma del colon-retto, in particolare per localizzazione perianale, il carcinoma della cervice uterina, dell’utero, dell’ovaio, della vagina, dell'epitelio transizionale dalla pelvi renale all'uretra ed il carcinoma mammario. Il morbo di Paget vulvare rappresenta un’entita clinica ben definita e la piu frequente fra le forme extramammarie, costituendo circa l’1% di tutte le neoplasie vulvari. La diagnosi si basa sulla presenza delle cellule di Paget nel contesto dell’epitelio, facilmente identificate all'esame istologico. La terapia della VPD prevede un’ampia escissione locale con una profondita di resezione tale da interessare tutti gli annessi cutanei. Nei casi in cui sia istologicamente dimostrata l'associazione con un adenocarcinoma sottostante invasivo o sia presente invasione stromale, occorre integrare l'approccio chirurgico vulvare alla linfoadenectomia inguino-femorale. Descriviamo il trattamento chirurgico di una paziente affetta da Paget vulvare, soffermandoci sul management clinico e i risultati ottenuti.

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