We designed a multi-institutional retrospective study to investigate the previously unreported failure pattern, survivals, and prognostic factors after postoperative radiotherapy (PORT) in triple negative breast cancer (TNBC) patients in South Korea.
Although an ascorbic acid-loaded dissolving microneedle patch has been developed to improve anti-wrinkle effects, an efficacy evaluation with a control group has not yet been performed. In this study, the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch was evaluated in a double-blind clinical study with a control group. In addition, a cumulative skin irritation and sensitization potential of the ascorbic acid-loaded dissolving microneedle patch was performed.Twenty-three subjects were selected for anti-wrinkle effect evaluation in a double-blind clinical study. Subjects were divided into two groups. Group I subjects applied an ascorbic acid-loaded dissolving microneedle patch on a crow's feet area on the left side of the face and a control sample on a crow's feet area on the right side of the face every 4 days. Group II subjects placed the same patches on opposite sides of the face. Global Photodamage Score and skin replica analysis were conducted by visual inspection and skin visiometer, respectively. A skin irritation and sensitization assessment was performed on 51 subjects using the modified Shelanski & Shelanski procedure. Cumulative skin irritation potential and skin sensitization of the ascorbic acid-loaded dissolving microneedle patch and control sample were evaluated.Skin treated with the ascorbic acid-loaded dissolving microneedle patch showed a statistically significant improvement in both the Global Photodamage Score and visiometer R values (P < 0.05) compared with the control sample. The R2 value (maximum roughness), in particular, showed a highly significant improvement (P < 0.01). The skin irritation and sensitization assessment demonstrated that the ascorbic acid-loaded dissolving microneedle patch did not induce any cumulative skin irritation potential or skin sensitization.An ascorbic acid-loaded dissolving microneedle patch produced a significant anti-wrinkle effect without skin irritation and sensitization problems. This cosmetic dissolving microneedle patch can be used efficiently in the anti-wrinkle cosmetic field with patient convenience.
Abstract Background Idiopathic guttate hypomelanosis (IGH) is a commonly acquired leucoderma that is characterized by discrete, round or oval porcelain‐white macules ∼2–5 mm in diameter that increases in number with age. A variety of therapies with variable success rates, including cryotherapy, superficial abrasion and topical retinoids are currently being used. Objectives The effects of fractional CO 2 laser therapy on IGH were investigated in this pilot study. Patients and methods A total of 40 patients with IGH were enrolled. The hypopigmented lesions were treated using a 10 600‐nm carbon dioxide fractional laser (CO 2 FL). Two months after a single treatment, physicians’ clinical assessments were performed and the patients’ overall satisfaction was evaluated. Results The mean age of enrolled patients was 57.5 ± 10.9 years and the gender ratio was 7 : 33. The face was the most commonly treated area, although the extremities are epidemiologically the most frequently affected areas. Two months after treatment, objective assessments performed by two independent dermatologists indicated more than 50% improvement in 36 patients (90%), compared with baseline. In addition, 33 patients (82.5%) were very satisfied or satisfied with just one session of CO 2 FL treatment. Although a few patients complained of long‐standing erythema and postinflammatory hyperpigmentation, these problems spontaneously resolved within 2 months after the assessments. No other noticeable side effects were observed. Conclusion CO 2 FL might be a very convenient and effective modality for treating IGH without significant side effects.
4641 Background: Recently, in technical aspects, almost all kinds of open gastric cancer surgeries can be reproduced laparoscopically. However, many controversies exist due to no evidence and no long-term results. There was no prospective multi-center large- scale randomized controlled trial in the world on the long-term outcome of laparoscopic gastric cancer surgery. Korean Laparoscopic Gastrointestinal Surgery Study Group, therefore, proposed a multi-institutional prospective randomized trial on comparing laparoscopy-assisted distal gastrectomy (LADG) versus open distal gastrectomy (ODG) for gastric cancer (KLASS Trial) after the feasibility and validity of these procedures had been evaluated by analyzing retrospective multi-center large series. Methods: Patient eligible criteria are as follows; pathologically proven gastric adenocarcinoma, age: 20 ∼ 80 years, preoperative stage: cT1N0M0, cT1N1M0, cT2aN0M0, no history of other cancer, no history of chemotherapy or radiotherapy, and written informed consent. Primary endpoint of this trial is to elucidate that there is no difference of overall survivals between LADG and ODG groups. The planned sample size per arm is 700 (1,400 in total). First of all, we compared morbidity and mortality between two groups by interim analysis in order to evaluate the safety of this trial. The time of interim analysis was decided on the hypothesis that the morbidity of this trial is not significantly different from that of previous reports on open gastric cancer surgeries (17%∼20%). Results: There were 179 LADG and 163 ODG patients. There was no significant difference between two groups in terms of age, gender, and comorbidity. Postoperative complication rates of LADG and ODG groups were 10.5% (17/179) and 14.7% (24/163), respectively (p=0.137). Reoperations were required in 3 cases of LADG and also 3 cases of ODG patients (p=1.000). Postoperative mortality was 1.1% (2/179) in LADG and 0% (0/163) in ODG patients (p=0.497). Conclusions: There was no significant difference of morbidity and mortality between LADG and ODG patients. This trial, therefore, is acceptable and should be ongoing. No significant financial relationships to disclose.
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