Mehmet Doğru

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i-10 index

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Comparison of the differences in circadian autonomic function in hyperlipidemic men with and without erectile dysfunction

International Urology and Nephrology (2009)

Mehmet Doğru M. Murad Başar

Hyperlipidemia

Autonomic function

10.1007/s11255-009-9658-2

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Citations (4)

Differences in left ventricular structure, functions and elastance in the patients with normotensive blood pressure.

Mehmet Doğru E. Tireli Mahmut Güneri Atila Iyısoy Turgay Çelik

OBJECTIVE We aimed in this study to investigate the differences in left ventricular (LV) structure, function and elastance parameters in the patients with normotensive blood pressure (BP) levels. METHODS A total of 294 normotensive patients (<140/90 mmHg) (135 males, mean age: 45+/-11 years; 159 females, mean age 38+/-10 years) were enrolled into the present cross-sectional study. Patients were categorized into three groups according to their BP levels as optimal BP (<120/80 mmHg), normal BP (120-129 / 80-84 mmHg) and high normal BP (129-139 / 84-89 mmHg) groups. We evaluated LV structure and functions by using Doppler echocardiography in all participants. Afterwards we compared the measurements for revealing the echocardiographic differences among the BP groups. In this study, one-way ANOVA Kruskal-Wallis, one-way ANCOVA and partial correlation analysis tests were used for the statistically evaluation of the data. In addition, relative risk ratios (RR) were also calculated for determination of the effects of BP levels to echocardiographic parameters. RESULTS There were significant statistical differences in left atrial diameter (LA) (p=0.002), transmitral A wave velocity (A) (p=0.002), meridional wall stress (MWS) (p<0.001), pulmonary capillary wedge pressure (PCW) (p=0.029) among BP groups. After the correction of the data for anthropometric measurements, multiple comparisons have shown that only end-systolic (Es) and end-diastolic elastance (Ed) were different between the normal and high-normal BP groups (for Es, p=0.013; for Ed, p=0.007). But it was found that optimal BP group had significant differences in LV structure and function parameters when compared to high normal BP group (for LA, p=0.028; for A, p=0.035; for MWS, p=0.002; for Es, p<0.001; for Ed, p<0.001). Besides, increased RR were detected for increased left atrial diameter index and pulmonary capillary wedge pressure values in high-normal BP group (RR: 1.537, 95% CI (1.197-1.974), p=0.005 and RR: 1.272, 95% CI (1.089-1.485), p=0.032, respectively). CONCLUSION Pathologic changes in LV due to increasing BP begin at below-hypertensive BP levels. It could be possible that normal BP stage is the beginning level of these changes.

Fractional shortening

Pulmonary wedge pressure

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Skeletal Dentoalveolar and Soft Tissue Effects of β Thalassemia Major

International Archives of Medical Research (2017)

Atılım Akkurta Mehmet Doğru Arzum Güler Doğru Kamile Keskin

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Production of lipase by a newly isolated Bacillus coagulans under solid-state fermentation using melon wastes

Applied Biochemistry and Biotechnology (2007)

Hüseyin Alkan Zübeyde Baysal Fikret Uyar Mehmet Doğru

Bacillus coagulans

Solid-State Fermentation

10.1007/bf02686016

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Citations (79)

A rial elect c romech c anical coupling int n erv r al and P-wav a e dispersion in healt l hy h elderl r y l

Nesligül Yıldırım Murat Tulmaç Vedat Şimşek Mehmet Doğru Haksun Ebinç

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Kinik Asitin Antioksidan ve Antimikrobiyal Kapasitesi

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi (2022)

Leyla Ercan Mehmet Doğru

Recently, agents with natural antioxidant and antimicrobial properties have been popularly studied. For this purpose, phenolic compounds, terpenes, and organic acids are examined in their antioxidant and antimicrobial properties. Of these, organic acids are increasingly being used in pharmacology, medicine, food, and industry. Quinic acid is a natural organic compound found in many edible fruits and plants. In this study, the antioxidant effect of quinic acid, which has the structure of cyclohexane carboxylic acid, was determined in vitro using seven different methods (DPPH, ABTS, CUPRAC, DMPD, FRAP, Fe3+ reduction, and Total antioxidant method). In addition, its antimicrobial effect on fungi (C. albicans), gram-positive bacteria (S. aureus, S. pyogenes), and gram-negative bacteria (E. coli, K. pneumoniae, and P. aeruginosa) were determined by the disk diffusion method. As a result, it was found that quinic acid has broad-spectrum antimicrobial properties, but its antioxidant properties are too low to be highlighted. While its antimicrobial activity was quite good, especially on K. pneumoniae E. coli, S. aureus, S. Pyogenes, and P. aeruginosa, it did not show any effect on C. albicans. Although the antioxidant property of quinic acid is low, it showed more antioxidant properties in the DMPD method, which is one of these methods, because it dissolves very well in water.

Quinic acid

ABTS

10.17798/bitlisfen.1167047

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Citations (11)

The Effects of Nocturnal Blood Pressure Paterns and Autonomic Alterations on Erectile Functions in Patients with Hypertension.

PubMed (2019)

Ercan Yuvanç Mehmet Doğru Vedat Şimşek Hüseyin Kandemir Devrim Tuğlu

Hypertension (HT) is known to be of the main risk factors for erectile dysfunction (ED). But non-dipping (<%10 drop in the night) of HT is not investigated truly. The aim of this study was to test the hypothesis that the non-dipper hypertensive patients are more prone to develop erectile dysfunction.This was a cross-sectional clinical study. 70 HT patients diagnosed by Ambulatory blood pressure monitoring (ABPM) were classified into 3 groups (No ED, mild to moderate and severe) according to their International Index of Erectile Function (IIEF) scores. All three groups were compared for their dipping status by ABPM, heart rate variability (HRV) by holter monitoring.In our study non-dipper hypertensives had statistically more erectile dysfunction (P=0.004). Also severe ED patients with non-dipping pattern had decreased dipping blood pressure levels then those of ED(-) patients with non-dipping HT (P= .003)(Daytime Systolic/Nighttime Diastolic Blood Pressure= 0.8 ± 0.07 / 3.90 ± 1.5, respectively). LF/HF daytime/ nighttime in holter reflecting sympathetic overactivity (P< .001).Autonomic dysfunction especially sympathetic overactivity is associated with both non dipping pattern of HT and erectile dysfunction as a common pathologic pathway, besides there might be an association between ED and non dipping HT.

Dipper

Autonomic function

10.22037/uj.v0i0.4135

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Citations (5)

We do our work with all our heart

Journal of Arrhythmia (2014)

İsmail Ateş Zeynettin Kaya Mehmet Doğru

These original images were encountered during interventional procedures. Awareness about the abnormalities that they depict is important to identify them. We present an original image of the coronary sinus lead. The lead was placed in the posterolateral branch of the coronary sinus during cardiac resynchronization therapy combined with implantation of an implantable cardioverter-defibrillator. We observed that the lead achieved a heart shape in the left anterior oblique position (Fig. 1). We would like to dedicate this image to all physicians who are devoted to their work. The fluoroscopic image showing the heart-shaped coronary sinus lead in the left anterior oblique position. We confirm that there are no known conflicts of interest associated with this publication.

Lead (geology)

Anterior wall

Position (finance)

10.1016/j.joa.2014.11.001

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Use of Natural Dye‐Casein Complexes: Effect of Proteolytic Treatment

Preparative Biochemistry & Biotechnology (2006)

Mehmet Doğru Zübeyde Baysal Çetin Aytekin Haluk Aydın

The activity of proteolytic enzymes is commonly measured using casein as a substrate. A modified caseinolysis assay was developed with natural dyes such as juglone, lawsone, berberine, and quercetin for Subtilisin carlsberg, protease type XVI, and trypsin, respectively. The pH dependence and incubation time were determined. K(m), V(max), and k(cat)/K(m) values were also determined for these enzymes. Lawsone was found to be a better substrate than the others.

Lawsone

Juglone

Proteolytic enzymes

Enzyme Kinetics

10.1080/10826060500533984

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Letters to the Editor Coronary stent strut fracture after drug-eluting stent implantation: A newly recognized complication

Turgay Çelik Atila Iyısoy Mehmet Doğru Ersoy Işık

Stent strut fracture (SSF) after drug-eluting stent (DES) implantation may be an important complication after DES implantation particularly in patients undergoing sirolimus eluting stent implantation. Since SSF is a highly relevant adverse event which can result in instent restenosis and thrombosis, we belive that DES with flexible stent platform or biodegradable DES may be needed to prevent this potential catastrophic complication. © 2007 Elsevier Ireland Ltd. All rights reserved.

Coronary stent

Sirolimus

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