Weijun Cui

ZheJiang Academy of Agricultural Sciences

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Jianping Chen

Ningbo University

Xinling Song

Second Hospital of Shandong University

Fei Yan

Ningbo University

Hongying Zheng

Ningbo University

Le Jia

Shandong Agricultural University

Jianjun Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

Yuwen Lu

Ningbo University

Jiejun Peng

Ningbo University

Kelei Han

Anhui Academy of Agricultural Sciences

Mengfei Ji

Ningbo University

Cooperative Institutions

ZheJiang Academy of Agricultural Sciences

Ningbo University

Zhejiang University

Shandong Agricultural University

Ministry of Agriculture and Rural Affairs

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Agricultural Sciences

Northwest A&F University

Huazhong University of Science and Technology

Nanjing Agricultural University

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A single amino acid in coat protein of Pepper mild mottle virus determines its subcellular localization and the chlorosis symptom on leaves of pepper

Journal of General Virology (2020)

Kelei Han Hongying Zheng Mengfei Ji Weijun Cui Shuzhen Hu

Pepper mild mottle virus (PMMoV) causes serious economic losses in pepper production in China. In a survey for viral diseases on pepper, two PMMoV isolates (named PMMoV-ZJ1 and PMMoV-ZJ2) were identified with different symptoms in Zhejiang province. Sequence alignment analysis suggested there were only four amino acid differences between the isolates: Val262Gly, Ile629Met and Ala1164Thr in the replicase, and Asp20Asn in the coat protein. Infectious cDNA clones of both isolates were constructed and shown to cause distinctive symptoms. Chlorosis symptoms appeared only on PMMoV-ZJ2-infected plants and the Asp20Asn substitution in the CP was shown to be responsible. Confocal assays revealed that the subcellular localization pattern of the two CPs was different, CP20Asp was mainly located at the cell periphery, whereas most CP20Asn located in the chloroplast. Thus, a single amino acid in the CP determined the chlorosis symptom, accompanied by an altered subcellular localization.

Mottle

Chlorosis

Coat

10.1099/jgv.0.001398

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Citations (17)

Structural characterization and amelioration of sulfated polysaccharides from Ganoderma applanatum residue against CCl4-induced hepatotoxicity

International Immunopharmacology (2021)

Xinling Song Weijun Cui Zheng Gao Jianjun Zhang Le Jia

CCL4

10.1016/j.intimp.2021.107554

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Citations (16)

Antioxidant and anti-ageing effects of enzymatic polysaccharide from Pleurotus eryngii residue

International Journal of Biological Macromolecules (2021)

Chen Zhang Xinling Song Weijun Cui Qihang Yang

Pleurotus eryngii

Residue (chemistry)

10.1016/j.ijbiomac.2021.01.030

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Citations (36)

Renoprotective effects of enzyme-hydrolyzed polysaccharides from Auricularia polytricha on adenine-induced chronic kidney diseases in mice

Biomedicine & Pharmacotherapy (2021)

Xinling Song Hui Pang Weijun Cui Jianjun Zhang Jian Li

The present work was aimed to investigate the protective effects of enzymatic-hydrolyzed Auricularia polytricha polysaccharides (EnAPS) on renal functions. The characterizations were analyzed by physicochemical methods, and the renoprotections were processed in adenine-induced chronic kidney diseases (CKD) models of mice. Animal experiments exhibited that EnAPS showed superior renal-protections contributing to its antioxidant effects of increasing the enzyme activities and decreasing the lipid contents, and anti-inflammatory effects of reducing proinflammatory cytokines than A. polytricha polysaccharides (APS). Besides, the anti-apoptosis effects of EnAPS was proved by down-regulating Bax and Caspase-3 expressions and up-regulating Bcl-2 expressions by molecular biotechnology, and the anti-fibrosis effects was confirmed by histopathological observations of staining. The characterizations indicated that lower molecular weights possibly contributed to the superior renoprotective effects. These results suggested that enzymatic hydrolysis had potential effects in enhancing the bioactivities, and the polysaccharides could be used in the development of functional foods supplement against CKD.

Proinflammatory cytokine

10.1016/j.biopha.2020.111004

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Citations (19)

Characterization of Proteins Involved in Chloroplast Targeting Disturbed by Rice Stripe Virus by Novel Protoplast–Chloroplast Proteomics

International Journal of Molecular Sciences (2019)

Jinping Zhao Jingjing Xu Binghua Chen Weijun Cui Zhongjing Zhou

Rice stripe virus (RSV) is one of the most devastating viral pathogens in rice and can also cause the general chlorosis symptom in

Proteome

Chlorosis

10.3390/ijms20020253

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Citations (29)

A polysaccharide of PFP-1 from Pleurotus geesteranus attenuates alcoholic liver diseases via Nrf2 and NF-κB signaling pathways

Food & Function (2021)

Xinling Song Wenxue Sun Weijun Cui Le Jia Jianjun Zhang

A polysaccharide named PFP-1 was isolated from the Pleurotus geesteranus fruiting body, and potential investigations on ameliorating oxidative stress and liver injury against alcoholic liver disease (ALD) were performed in mice.

Pleurotus

10.1039/d1fo00310k

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Citations (31)

Structural characterization of Hericium erinaceus polysaccharides and the mechanism of anti-T2DM by modulating the gut microbiota and metabolites

International Journal of Biological Macromolecules (2023)

Weijun Cui Xinling Song Xueping Li Le Jia Chen Zhang

Hericium erinaceus

10.1016/j.ijbiomac.2023.125165

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Citations (20)

Downregulation of Light-Harvesting Complex II Induces ROS-Mediated Defense Against Turnip Mosaic Virus Infection in Nicotiana benthamiana

Frontiers in Microbiology (2021)

Shiyou Qiu Xuwei Chen Yushan Zhai Weijun Cui Xuhong Ai

The light-harvesting chlorophyll a / b complex protein 3 (LHCB3) of photosystem II plays important roles distributing the excitation energy and modulating the rate of state transition and stomatal response to abscisic acid. However, the functions of LHCB3 in plant immunity have not been well investigated. Here, we show that the expression of LHCB3 in Nicotiana benthamiana ( NbLHCB3 ) was down-regulated by turnip mosaic virus (TuMV) infection. When NbLHCB3 was silenced by tobacco rattle virus-induced gene silencing, systemic infection of TuMV was inhibited. H 2 O 2 was over-accumulated in NbLHCB3 -silenced plants. Chemical treatment to inhibit or eliminate reactive oxygen species (ROS) impaired the resistance of the NbLHCB3 -silenced plants to TuMV infection. Co-silencing of NbLHCB3 with genes involved in ROS production compromised the resistance of plants to TuMV but co-silencing of NbLHCB3 with genes in the ROS scavenging pathway increased resistance to the virus. Transgenic plants overexpressing NbLHCB3 were more susceptible to TuMV. These results indicate that downregulation of NbLHCB3 is involved in defense against TuMV by inducing ROS production.

Turnip mosaic virus

Tobacco rattle virus

10.3389/fmicb.2021.690988

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Suppression of nbe‐miR166h‐p5 attenuates leaf yellowing symptoms of potato virus X on Nicotiana benthamiana and reduces virus accumulation

Molecular Plant Pathology (2018)

Shu Wang Weijun Cui Xinyang Wu Quan Yuan Jinping Zhao

MicroRNAs (miRNAs) play essential roles in plant development. There is increasing evidence that changed expression of miRNAs in virus-infected plants contributes to the development of viral symptoms. Here, we analysed the altered expression of miRNAs of Nicotiana benthamiana in response to Potato virus X (PVX) by Illumina Solexa sequencing. One of the 21 miRNAs significantly affected, nbe-miR166h-p5, was closely associated with viral symptoms. Using the Tobacco rattle virus-based miRNA suppression (VbMS) system, we found that the suppression of nbe-miR166h-p5 in plants caused leaves to turn dark green with increased chlorophyll. When PVX was inoculated on nbe-miR166h-p5-suppressed plants, the leaf yellowing symptom of PVX was largely attenuated with less reduction in chlorophyll content, and the accumulation of PVX was decreased. nbe-miR166h-p5 was also up-regulated in plants infected by Turnip mosaic virus (TuMV), and its suppression attenuated the leaf yellowing symptom of TuMV and decreased viral accumulation. Three potential targets of nbe-miR166h-p5 were identified. The results indicate the association of nbe-miR166h-p5 with symptoms of PVX and also with those of TuMV, providing useful information on the relationship between miRNA and viral infection.

Potato virus X

Potexvirus

Turnip mosaic virus

Tobacco rattle virus

10.1111/mpp.12717

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Citations (19)

Stropharia rugoso-annulata acetylated polysaccharides alleviate NAFLD via Nrf2/JNK1/AMPK signaling pathways

International Journal of Biological Macromolecules (2022)

Xueping Li Weijun Cui Yanfei Cui Xinling Song Le Jia

10.1016/j.ijbiomac.2022.06.156

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Citations (19)