Lijuan Zhao

Nanjing University of Chinese Medicine

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Li Lin

Zhongkai University of Agriculture and Engineering

Jun Li

The University of Texas Health Science Center at Houston

Zhendong Qin

Zhongkai University of Agriculture and Engineering

Ming Bai

First Affiliated Hospital of Henan University

Yan Yu

China Rehabilitation Research Center

Yi‐Chao Zheng

Zhengzhou University

Hong‐Min Liu

Zhengzhou University

Zhijie Lu

South China Normal University

Jiagang Tu

Huazhong Agricultural University

Meilan Zhou

Wuhan Pulmonary Hospital

Cooperative Institutions

Chinese Academy of Sciences

228

Chinese Academy of Medical Sciences & Peking Union Medical College

179

Zhengzhou University

147

Shandong University

142

Shanghai Jiao Tong University

130

Nanjing Medical University

121

Peking University

118

Sichuan University

118

Sun Yat-sen University

108

Air Force Medical University

103

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Impact of therapeutic plasmapheresis on the duration of organ failure in patients with hypertriglyceridemia-associated acute pancreatitis

Annals of Intensive Care (2024)

Lanting Wang Jing Zhou Cheng Lv Donghuang Hong Zuozheng Wang

Abstract Background Plasmapheresis is widely used for severe hypertriglyceridemia-associated acute pancreatitis (HTG-AP) to remove excessive triglycerides from plasma. This study aimed to evaluate whether plasmapheresis could improve the duration of organ failure in HTG-AP patients. Methods We analyzed a cohort of patients from a multicenter, prospective, long-running registry (the PERFORM) collecting HTG-AP patients admitted to the study sites within 72 h from the onset of symptoms. This study was based on data collected from November 2020 to March 2023. Patients who had organ failure at enrollment were involved in the analyses. The primary outcome was time to organ failure resolution within 14 days. Multivariable Cox regression model was used to evaluate the association between plasmapheresis and time to organ failure resolution. Directed acyclic graph (DAG) was used to identify potential confounders. Results A total of 122 HTG-AP patients were included (median [IQR] sequential organ failure assessment (SOFA) score at enrollment, 3.00 [2.00–4.00]). Among the study patients, 46 underwent plasmapheresis, and 76 received medical treatment. The DAG revealed that baseline serum triglyceride, APACHE II score, respiratory failure, cardiovascular failure, and renal failure were potential confounders. After adjusting for the selected confounders, there was no significant difference in time to organ failure resolution between patients undergoing plasmapheresis and those receiving exclusive medical treatment (HR = 1.07; 95%CI 0.68–1.68; P = 0.777). Moreover, the use of plasmapheresis was associated with higher ICU requirements (97.8% [45/46] vs. 65.8% [50/76]; OR, 19.33; 95%CI 2.20 to 169.81; P = 0.008). Conclusions In HTG-AP patients with early organ failure, plasmapheresis was not associated with accelerated organ failure resolution compared to medical treatment but may be associated with more ICU admissions. Trial registration : The PERFORM study was registered in the Chinese Clinical Trial Registry (ChiCTR2000039541). Registered 30 October 2020.

Plasmapheresis

10.1186/s13613-024-01285-3

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Citations (1)

Association of URG11 and Twist with clinical pathological characteristics and prognosis in patients with IgA nephropathy

Nephrology Dialysis Transplantation (2013)

Rui Du Lijuan Zhao Xia Li L. Liu Wenjuan Sun

BackgroundOur previous studies demonstrated that URG11 is involved in hypoxia-induced tubular epithelial–mesenchymal transition and the development of kidney fibrosis in cellular and animal models. The objective of this study was to determine the expression levels of URG11 in kidneys with IgA nephropathy (IgAN), and the association of URG11 with various clinical parameters.

10.1093/ndt/gft252

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Citations (6)

Transcriptomic analysis of the head kidney of Topmouth culter ( Culter alburnus ) infected with Flavobacterium columnare with an emphasis on phagosome pathway

Fish & Shellfish Immunology (2016)

Lijuan Zhao Jiagang Tu Yulei Zhang Jinfu Wang Ling Yang

KEGG

Housekeeping gene

10.1016/j.fsi.2016.09.001

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Citations (38)

Dual-modal aptasensor based on multifunctional acridone derivative for rapid detection of exosomal proteins and cancer diagnosis

Sensors and Actuators B Chemical (2024)

Yaokun Xia Gengzhen Zhu Lijuan Zhao Caixia Yan Ze‐Ning Huang

Acridone

Derivative (finance)

10.1016/j.snb.2024.135517

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Citations (5)

FP326REGIONAL CITRATE ANTICOAGULATION vs. NO-ANTICOAGULATION FOR CONTINUORS VENOVENOUS HEMOFILTRATION IN PATIENTS WITH LIVER FAILURE AND INCREASED BLEEDING RISK: A RETROSPECTIVE CASE-CONTROL STUDY

Nephrology Dialysis Transplantation (2019)

Yan Yu Feng Ma Yangping Li Lijuan Zhao Li Li

Hemofiltration

10.1093/ndt/gfz106.fp326

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Application of fly ash in the treatment of oil-containing wastewater

Li Shuxin Lijuan Zhao

In order to solve the environmental pollution caused by oil-containing wastewater and fly ash, application of fly ash as sorbent, added after modification and combined with other process in the treatment of oil-containing wastewater was summarized. The results show that application of fly ash in oil-containing wastewater treatment has the characteristic of simple in process, good effect and lower operation cost. And this process has expansive application foreground. The problems remained were pointed out. Further research on the mechanism of wastewater treatment with fly ash, separation and final utilization of the saturated fly ash are needed to do in the near future.

Expansive

10.1109/icetce.2011.5774192

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Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis

Molecules (2021)

Zhiman Li Lijuan Zhao Yunshi Xia Jianbo Chen Hua Mei

The activation of hepatic stellate cells (HSC) plays a key role in the progression of hepatic fibrosis, it is essential to remove activated HSC through apoptosis to reverse hepatic fibrosis. Schisandrin B (Sch B) is the main chemical component of schisandrin lignan, and it has been reported to have good hepatoprotective effects. However, Schisandrin B on HSC apoptosis remains unclear. In our study, we stimulated the HSC-T6 and LX-2 cell lines with TGF-β1 to induce cell activation, and the proliferation and apoptosis of the activated HSC-T6 and LX-2 cells were detected after treatment with different doses of Schisandrin B. Flow cytometry results showed that Sch B significantly reduced the activity of activated HSC-T6 and LX-2 cells and significantly induced apoptosis. In addition, the cleaved-Caspase-3 levels were increased, the Bax activity was increased, and the Bcl-2 expression was decreased in HSC-T6 and LX-2 cells treated with Sch B. Our study showed that Sch B inhibited the TGF-β1-induced activity of hepatic stellate cells by promoting apoptosis.

Hepatic stellate cell

Hepatic fibrosis

10.3390/molecules26226882

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Citations (15)

Mannose receptor of Epinephelus coioides exerts antiviral activity against red-spotted grouper nervous necrosis virus and regulates apoptosis and inflammation

Aquaculture (2021)

Menglan Zhang Zhijie Lu Meizhen Tang Gan Pan Lijuan Zhao

Mannose receptor

10.1016/j.aquaculture.2021.737264

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Effect of velvet antler on the immune activity of cyclophosphamide-induced immunosuppressed mice

Food and Agricultural Immunology (2022)

Songxin Liu Zhiman Li Zi-jun Shao Yunshi Xia Lijuan Zhao

To study the antioxidant and immune protection activity of velvet antler (VA) in cyclophosphamide-induced immunocompromised mice, BALB/c mice were intragastrically administered 100, 300, or 500 mg/(kg·d) VA for 30 days, and were intraabdominally injected with cyclophosphamide to create a hypoimmune murine model. Cellular immunity, macrophage phagocytic activity, natural killer (NK) cell activity, white blood cell count, splenic lymphocyte subsets and the mRNA expression levels of serum cytokines were analysed. We found that the IC50 for removing 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), OH, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals of VA were 0.476, 4.33, and 37.92 mg/mL, respectively. VA could enhance innate and adaptive immunity of mice by improving cellular immunity, macrophage phagocytic ability, and NK cell activity; promoting the production of IL-4, IFN-γ, TNF-α and other cytokines; increasing the content and ratio of lymphocyte subsets. These results indicate that VA has good antioxidant activity and can improve the immune function of cyclophosphamide-induced immunodeficient mice.

ABTS

Cellular immunity

White blood cell

10.1080/09540105.2022.2128070

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Citations (2)

Anticoagulant Therapy Improves Survival in Non-COVID-19 Pneumonia: A Retrospective Cohort Study

Haiming Hu Yixing Zhu Rong Hu Xiangwen Zeng Lijuan Zhao

Anticoagulant Therapy

2019-20 coronavirus outbreak

10.2139/ssrn.5076145

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