Chuankai Xia

Second Hospital of Anhui Medical University

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Chunjun Yang

Second Hospital of Anhui Medical University

Cheng Cheng

Chinese Academy of Sciences

Xingyu Yang

Heilongjiang Provincial Hospital

Zhicheng Cao

Xidian University

Randy Ko

University of New Mexico

Jing Gao

Chengdu University of Traditional Chinese Medicine

Yajun Guo

Northeastern University

Changbing Shen

Taizhou Second People's Hospital

Liyun Wang

Nantong University

Zheng Bao Lei

United States Naval Academy

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Anhui Medical University

Second Hospital of Anhui Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Nanjing University

Changi General Hospital

University of New Mexico

Chengdu University of Traditional Chinese Medicine

Harbin Medical University

First Affiliated Hospital of Harbin Medical University

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Cold atmospheric plasma promotes different types of superficial skin erosion wounds healing

International Wound Journal (2019)

Jing Gao Liyun Wang Chuankai Xia Xingyu Yang Zhicheng Cao

Abstract Superficial skin erosion wounds are very common in the clinic, and conventional treatments are not always effective; thus, effective and novel therapy is needed. Cold atmospheric plasma (CAP) has been recognised as a promising approach to wound healing. The purpose of this study is to show the potential clinical application of CAP for the healing of different kinds of superficial skin wounds. Seven patients with different kinds of superficial skin wounds (two patients with pyoderma gangrenosum, two patients with trauma would, one patient with giant genital wart, one patient with diabetic foot, and one patient with chronic eczema) were recruited to this study. All patients accepted and received CAP treatment every other day till the wound healed. The expected results were complete wound healing after CAP treatment. All patients achieved complete wound healing after several rounds (range from two to eight) of CAP treatment, and there was no side effect observed. CAP may provide a new and effective choice to solve the problem of the healing of superficial wounds that are not only caused by trauma but also because of eczema. CAP has certain value in the treatment of superficial skin diseases in the future.

Sex organ

10.1111/iwj.13161

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Bactericidal efficacy of cold atmospheric plasma treatment against multidrug-resistant Pseudomonas aeruginosa

Future Microbiology (2020)

Liyun Wang Chuankai Xia Yajun Guo Chunjun Yang Cheng Cheng

Aim: The global of spread multidrug-resistant Pseudomonas aeruginosa has become a public health threat. Cold atmospheric plasma (CAP) is reported to have bactericidal efficacy; however, its effects on clinical super multidrug-resistant P. aeruginosa are unclear. The aim of this study was to investigate the bactericidal efficacy of CAP on a strain of super multidrug-resistant P. aeruginosa. Materials & methods: The effects of CAP treatments were evaluated using assays for the detection of growth, viability, metabolism, virulence factors and reactive oxygen species (ROS) levels. Results: Both CAP treatments dose-dependently inhibited cell viability and metabolic activity, and decreased the expression of several virulence factors. CAP treatment induced a significant increase in intracellular ROS levels, and ROS scavengers inhibited this effect. Conclusion: CAP treatment is a promising option for the clinical inhibition of multidrug-resistant P. aeruginosa, and the development of CAP technologies might be the key to solving the long-standing problem of drug-resistant bacteria.

10.2217/fmb-2019-0265

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Citations (24)