Marguerite M. Engler

Uniformed Services University of the Health Sciences

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i-10 index

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Co-Authors

Mary B. Engler

Uniformed Services University of the Health Sciences

Mary J. Malloy

University of California, San Francisco

Penny M. Kris‐Etherton

Pennsylvania State University

Frank M. Sacks

Harvard University

Nancy A. Stotts

University of California, San Francisco

Deanna L. Kroetz

University of California, San Francisco

Erika Sivarajan Froelicher

University of San Francisco

Lawrence J. Appel

Johns Hopkins University

Michele Mietus‐Snyder

Children's National

Thomas P. Flagg

Uniformed Services University of the Health Sciences

Cooperative Institutions

University of California, San Francisco

National Institutes of Health

Harvard University

Brigham and Women's Hospital

University of California, Davis

Stanford University

University of Washington

Tufts University

Uniformed Services University of the Health Sciences

Washington University in St. Louis

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Pediatric Hyperlipidemia: Child and Adolescent Disease Understandings and Perceptions About Dietary Adherence

Journal for Specialists in Pediatric Nursing (2008)

Susan Kools Christine Kennedy Marguerite M. Engler Mary B. Engler

PURPOSE. Pediatric hyperlipidemia increases cardiovascular disease risk. The cornerstone of treatment is a restrictive, lipid‐lowering diet. Child disease understandings and perceptions of dietary adherence were explored, a secondary aim of the Endothelial Assessment of Risk from Lipids in Youth trial. DESIGN AND METHODS. Focus groups and individual interviews were conducted with participants, ages 9–20 years ( n = 50). Data were thematically analyzed. FINDINGS. Adherence is influenced by individual characteristics (developmental level, knowledge), in the context of social interactions (family modeling, peer relationships, school). PRACTICAL IMPLICATIONS. Dietary practices are developed within social interactions. Interventions promoting adherence must consider children within their social contexts.

Hyperlipidemia

Cornerstone

10.1111/j.1744-6155.2008.00151.x

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Citations (10)

γ-Linolenic acid: a pharmacological nutrient for hypertension?

Jean‐Pierre Poisson Sandrine H. Bellenger‐Germain Marguerite M. Engler Huang YungSheng Michel Narce

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The Effects of Berry Extracts on Oxidative Stress in Cultured Cardiomyocytes and Microglial Cells: A Potential Cardioprotective and Neuroprotective Mechanism

Molecules (2022)

Tanisha L. Currie Marguerite M. Engler Cara Olsen Victor Krauthamer Jonathan M. Scott

Oxidative stress is a key underlying factor in cognitive decline and atherosclerosis. Oxidative stress occurs at the cellular level with an imbalance between reactive oxygen species and reactive nitrogen species and a deficiency in antioxidants. Mounting evidence suggests that berry flavonoids may promote cellular health by exerting antioxidant properties. Black currant and various berry extracts were tested in microglia (BV-2) and cardiomyocyte (HL-1) cell lines to study their biological effects. The principal ingredients in black currant and cranberry extract-delphinidin 3-rutinoside (D3R) and cyanidin 3-glucoside (C3G), were also assessed. A menadione-induced oxidative stressor was used, and its output was quantified to detect oxidative stress (CellROXTM). Black currant extract had similar antioxidant effects as N-acetylcysteine (NAC) in HL-1 cells with regard to cellular protection, whereas cranberry extract was ineffective. In contrast, cranberry extract was comparable in effectiveness to black currant extract in BV-2 cells. D3R and C3G also reduced oxidative stress similarly to whole berry extracts, which indicates that these ingredients may confer the antioxidant effects of berries. Black currant and cranberry extracts inhibit oxidative stress in microglial and cardiomyocyte cell lines. Black currant extract was more effective in reducing oxidative stress in the HL-1 cells, whereas cranberry extract was comparable in reducing oxidative stress in the BV-2 cells. The results suggest that berry flavonoids exert neuro- and cardioprotective effects.

10.3390/molecules27092789

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Citations (6)

The Cardioprotective Effects of Flavonoids

Marguerite M. Engler Mary B. Engler

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Considerations for Optimizing Warfighter Psychological Health with a Research-Based Flavonoid Approach: A Review

Nutrients (2023)

Tanisha L. Currie Marguerite M. Engler Victor Krauthamer Jonathan M. Scott Patricia A. Deuster

Optimal nutrition is imperative for psychological health. Oxidative stress and inflammation are underlying etiologies for alterations in psychological health. Warfighters are at risk of health concerns such as depression due to increased stress in austere environments and family separation while deployed. Over the last decade, research has demonstrated the health benefits of flavonoids found in fruits and berries. Berry flavonoids have potent antioxidant and anti-inflammatory properties by inhibiting oxidative stress and inflammation. In this review, the promising effects of various berries rich in bioactive flavonoids are examined. By inhibiting oxidative stress, berry flavonoids have the potential to modulate brain, cardiovascular, and intestinal health. There is a critical need for targeted interventions to address psychological health concerns within the warfighter population, and a berry flavonoid-rich diet and/or berry flavonoid dietary supplement intervention may prove beneficial as an adjunctive therapy. Structured searches of the literature were performed in the PubMed, CINAHL, and EMBASE databases using predetermined keywords. This review focuses on berry flavonoids’ critical and fundamental bioactive properties and their potential effects on psychological health in investigations utilizing cell, animal, and human model systems.

CINAHL

Health Benefits

Depression

10.3390/nu15051204

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Citations (6)

Accountability and Transparency in Medical Publishing: Position and Policies of Le Jacq on Authorship, Acknowledgments, Conflicts of Interest, and Secondary and Redundant Publication

The American Heart Hospital Journal (2008)

Gene Snyder Elizabeth B. Ferretti Nanette K. Wenger John E. Strobeck Marc A. Silver

Atlanta

Haven

Columbia university

10.1111/j.1751-7168.2008.08161.x

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Citations (2)

Perceived learning needs of patients with coronary artery disease using a questionnaire assessment tool

Heart & Lung (1997)

Mildred Czar Mlittnsg Ed Marguerite M. Engler

Marital status

Content Validity

10.1016/s0147-9563(97)90070-4

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Citations (58)

Lipoprotein‐Associated Phospholipase A₂: A Promising Vascular‐Specific Marker for Screening Cardiovascular Risk?

Progress in Cardiovascular Nursing (2009)

Joung Hee Lee Marguerite M. Engler

Atherosclerosis is an inflammatory disease that can be assessed by circulating biomarkers. Lipoprotein‐associated phospholipase A 2 (Lp‐PLA 2 ) is an enzyme produced in atherosclerotic plaque and is bound to low density lipoprotein and high‐density lipoprotein cholesterol. It has a role in the pathogenesis of atherosclerosis by promoting vascular inflammation. It is emerging as a vascular‐specific marker and predictor of risk for cardiovascular disease (CVD) events. Increasing evidence from many prospective epidemiologic studies have shown that elevated levels of Lp‐PLA 2 are associated with future CVD events. Measurement of Lp‐PLA 2 in individuals may provide clinically relevant information about their future risk of CVD events. Pharmacologic therapies and/or risk factor modification could be initiated after identification of individuals at risk for CVD. This review provides an overview of the pathophysiology, epidemiologic evidence, and clinical utility of Lp‐PLA 2 .

Pathogenesis

Lipoprotein-associated phospholipase A2

Lipoprotein(a)

Pathophysiology

10.1111/j.1751-7117.2009.00057.x

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Citations (3)

The Emerging Role of Flavonoid-Rich Cocoa and Chocolate in Cardiovascular Health and Disease

Nutrition Reviews (2006)

Mary B. Engler Marguerite M. Engler

Cocoa and chocolate have recently been found to be rich plant-derived sources of antioxidant flavonoids with beneficial cardiovascular properties. These favorable physiological effects include: antioxidant activity, vasodilation and blood pressure reduction, inhibition of platelet activity, and decreased inflammation. Increasing evidence from experimental and clinical studies using cocoa-derived products and chocolate suggest an important role for these high-flavanol-containing foods in heart and vascular protection.

Dark chocolate

Cardiovascular Health

10.1301/nr.2006.mar.109-118

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Citations (13)

The Mediterranean Diet: Is It Cardioprotective?

Progress in Cardiovascular Nursing (2005)

Marita C. Bautista Marguerite M. Engler

Coronary heart disease is one of the leading causes of morbidity and mortality in the United States. Dietary interventions are first-line therapy for coronary heart disease prevention and treatment. Increasing scientific evidence suggests that the traditional Mediterranean diet may reduce the risk of cardiovascular disease. The cardiovascular benefits of this whole-diet approach may outweigh those of typically prescribed low-fat diets. The burden of coronary heart disease is enormous, and nutritional approaches that optimize cardiovascular health are essential. Clinical trial evidence supporting the role of the Mediterranean diet in cardiovascular health is presented with an emphasis on the physiological effects of omega-3 fatty acids. Implications for clinical practice and future research are also discussed.

Mediterranean Diet

Cardiovascular Health

Secondary Prevention

Clinical Practice

10.1111/j.0889-7204.2005.04558.x

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Citations (34)