Constantin-Alin Maftei

Technical University of Munich

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Christine Bayer

Klinikum rechts der Isar

Kuangyu Shi

University of Bern

Peter Vaupel

University Medical Center Freiburg

Sabrina T. Astner

Praxis für Humangenetik

Sibylle Ziegler

Ludwig-Maximilians-Universität München

Sung-Cheng Huang

University of California, Los Angeles

Michaël Baumann

Heidelberg University

Daniela Schilling

Technical University of Munich

Ala Yaromina

Maastricht University

Daniel Zips

University Children's Hospital Tübingen

Cooperative Institutions

Klinikum rechts der Isar

Technical University of Munich

Heidelberg University

German Cancer Research Center

München Klinik

Deutschen Konsortium für Translationale Krebsforschung

Klinik und Poliklinik für Strahlentherapie und Radioonkologie

Klinik und Poliklinik für Nuklearmedizin

University Hospital Carl Gustav Carus

Ludwig-Maximilians-Universität München

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Comparison of (immuno-)fluorescence data with serial [18F]Fmiso PET/CT imaging for assessment of chronic and acute hypoxia in head and neck cancers

Radiotherapy and Oncology (2011)

Constantin-Alin Maftei Kuangyu Shi Christine Bayer Sabrina T. Astner Peter Vaupel

PET Imaging

Hypoxia

10.1016/j.radonc.2011.05.079

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Citations (17)

Quantifying the heterogeneity of tumor microvasculature using pharmacokinetic modeling for [18F]FMISO PET

Kuangyu Shi Christine Bayer Constantin-Alin Maftei Sabrina T. Astner Florian Gaertner

Biodistribution

Source

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Citations (1)

Changes in the fraction of total hypoxia and hypoxia subtypes in human squamous cell carcinomas upon fractionated irradiation: Evaluation using pattern recognition in microcirculatory supply units

Radiotherapy and Oncology (2011)

Constantin-Alin Maftei Christine Bayer Kuangyu Shi Sabrina T. Astner Peter Vaupel

Hypoxia

Tumor Hypoxia

10.1016/j.radonc.2011.05.023

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Citations (17)

Preclinical evaluation of parametric image reconstruction of [¹⁸F]FMISO PET: correlation withex vivoimmunohistochemistry

Physics in Medicine and Biology (2013)

Xiaoyin Cheng Christine Bayer Constantin-Alin Maftei Sabrina T. Astner Peter Vaupel

Compared to indirect methods, direct parametric image reconstruction (PIR) has the advantage of high quality and low statistical errors. However, it is not yet clear if this improvement in quality is beneficial for physiological quantification. This study aimed to evaluate direct PIR for the quantification of tumor hypoxia using the hypoxic fraction (HF) assessed from immunohistological data as a physiological reference. Sixteen mice with xenografted human squamous cell carcinomas were scanned with dynamic [18F]FMISO PET. Afterward, tumors were sliced and stained with H&E and the hypoxia marker pimonidazole. The hypoxic signal was segmented using k-means clustering and HF was specified as the ratio of the hypoxic area over the viable tumor area. The parametric Patlak slope images were obtained by indirect voxel-wise modeling on reconstructed images using filtered back projection and ordered-subset expectation maximization (OSEM) and by direct PIR (e.g., parametric-OSEM, POSEM). The mean and maximum Patlak slopes of the tumor area were investigated and compared with HF. POSEM resulted in generally higher correlations between slope and HF among the investigated methods. A strategy for the delineation of the hypoxic tumor volume based on thresholding parametric images at half maximum of the slope is recommended based on the results of this study.

Ex vivo

PET Imaging

Statistical parametric mapping

10.1088/0031-9155/59/2/347

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Citations (8)

Monitoring PAI-1 and VEGF Levels in 6 Human Squamous Cell Carcinoma Xenografts During Fractionated Irradiation

International Journal of Radiation Oncology*Biology*Physics (2012)

Christine Bayer Achim Kielow Daniela Schilling Constantin-Alin Maftei Daniel Zips

CD31

Colocalization

Plasminogen activator inhibitor-1