Felix Jebasingh

Christian Medical College & Hospital

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Nihal Thomas

Christian Medical College & Hospital

Thomas Vizhalil Paul

Christian Medical College & Hospital

Nitin Kapoor

Christian Medical College & Hospital

Kripa Elizabeth Cherian

Christian Medical College & Hospital

Hesarghatta Shyamasunder Asha

Christian Medical College & Hospital

Riddhi Dasgupta

Medical College and Hospital, Kolkata

Aaron Chapla

Christian Medical College & Hospital

Hesarghatta S. Asha

Christian Medical College & Hospital

Dukhabandhu Naik

Jawaharlal Institute of Post Graduate Medical Education and Research

Deny Varghese

Christian Medical College & Hospital

Cooperative Institutions

Christian Medical College & Hospital

224

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138

Christian Medical College

137

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All India Institute of Medical Sciences

Institute of Post Graduate Medical Education and Research

Institute of Medical Sciences

Post Graduate Institute of Medical Education and Research

Medical College and Hospital, Kolkata

All India Institute of Medical Sciences Raipur

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Very long-chain acyl-coenzyme A dehydrogenase deficiency —A rare monogenic steatotic liver disease presenting with acute liver injury in adulthood: A case report and brief review on nutrition management

Indian Journal of Gastroenterology (2025)

Leenath Thomas Kausala Sithamparapillai Thomas Alex Kodiatte Felix Jebasingh Sumita Danda

Rare disease

Liver disease

10.1007/s12664-025-01739-x

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Osteoporosis knowledge and beliefs among postmenopausal women: A cross-sectional study from a teaching hospital in southern India

Journal of Family Medicine and Primary Care (2019)

HesarghattaShyamasunder Asha Manickavasagam Senthilraja KripaElizabeth Cherian Felix Jebasingh Nitin Kapoor

Osteoporosis continues to be underrecognized in many parts of India. This study was undertaken to assess the level of knowledge of osteoporosis among postmenopausal women referred for a dual-energy X-ray absorptiometry (DXA) scan in a teaching hospital in southern India.This cross-sectional study assessed the state of awareness in consecutive postmenopausal women referred for a DXA scan using a validated questionnaire - Osteoporosis Knowledge Assessment Tool. The proportion of correct responses was expressed as percentages. The mean scores obtained were also compared between different educational groups.A total of 302 consecutive postmenopausal women who were referred for DXA participated in this study. The mean (standard deviation) age of the postmenopausal women included in this study was 58.8 (6) years. Although most subjects were aware of the consequences of osteoporosis, there was generalized lack of awareness with regard to risk factors and available treatment options. Overall about 60% had poor awareness about osteoporosis.This study showed a gross deficit in awareness of osteoporosis in Indian postmenopausal women. There is a need to prioritize on designing appropriate awareness campaigns in subjects at risk, according to their level of literacy.

Cross-sectional study

10.4103/jfmpc.jfmpc_95_19

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Citations (40)

Video Assisted Thoracoscopic Surgery (VATS) for Excision of an Ectopic Anterior Mediastinal Intra- Thymic Parathyroid Adenoma

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2016)

Dukhabandhu Naik Felix Jebasingh Ramprasath Birla Roy Gnanamuthu Mazhuvanchary Jacob Paul

Ectopic anterior mediastinal parathyroid adenoma is a rare cause of Primary Hyperparathyroidism (PHPT). Imaging studies such as Technetium-99m ((99m)Tc) sestamibi parathyroid scan along with a Single Photon Emission Computerized Tomogram (SPECT), and contrast enhanced Computerized Tomogram (CT) of the neck and thorax can precisely localize the ectopic mediastinal parathyroid adenoma. We report a 40-year-old gentleman who presented with persistent pain in the right shoulder following trivial trauma. His biochemical investigations showed an elevated serum calcium of 11.6mg% (Normal: 8.3-10.4 mg%) along with an elevated iPTH of 1443 pg/ml (normal: 8-70 pg/ml) which were suggestive of primary hyperparathyroidism. The localization studies revealed an ectopic cystic parathyroid adenoma in the anterior mediastinum that was not accessible from the neck. He underwent a Video Assisted Thoracoscopic (VAT) excision procedure with normalization of serum calcium and an uncomplicated recovery. The VAT approach is a successful minimally invasive technique for mediastinal parathyroidectomy.

Anterior mediastinum

Video-assisted thoracoscopic surgery

10.7860/jcdr/2016/18108.8023

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Citations (14)

Cretinism presenting as a pseudotumour

BMJ Case Reports (2015)

D M Mahesh Felix Jebasingh Manash Baruah Nihal Thomas

A 43-year-old man from a remote part of India (over 1800 km from our institution), presented with a headache of 3 years duration. He was of short stature, had delayed puberty and was mentally retarded. On evaluation he was detected to have primary hypothyroidism with markedly elevated thyroid-stimulating hormone titres. A CT of the brain revealed a large sellar mass with suprasellar extension into the third ventricle causing obstructive hydrocephalus. Surgical intervention was deferred due to absence of visual impairment and the presence of gross hypothyroidism. The clinical diagnosis of congenital hypothyroidism was confirmed by the absence of radioiodine uptake in the thyroid bed. With thyroid hormone replacement therapy, the ‘tumour’ underwent significant reduction in size with the resolution of hydrocephalus thereby favouring a potential pituitary pseudotumour. This was an unusual situation of a giant pituitary pseudotumour detected in an adult with untreated congenital hypothyroidism.

Cretinism

Pituitary disorder

Hormone replacement

10.1136/bcr-2014-206124

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Citations (2)

Bilateral maxillary brown tumours as the first presentation of primary hyperparathyroidism

Oral and Maxillofacial Surgery (2008)

Felix Jebasingh Jubbin Jacob A.V. Shah Thomas Vizhalil Paul M. S. Seshadri

Presentation (obstetrics)

Brown tumor

Osteitis fibrosa cystica

Mandible (arthropod mouthpart)

Rare disease

10.1007/s10006-008-0105-9

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Citations (32)

Subclinical hypothyroidism

Current Medical Issues (2018)

Felix Jebasingh Dukhabandhu Naik Nihal Thomas

Subclinical hypothyroidism (SCH) is defined as an elevated serum thyroid-stimulating hormone level with a normal total and free thyroxine (T4) level. There is a certain degree of debate regarding the risks associated with this condition and whether treatment is beneficial. Individuals with SCH are either asymptomatic or present with milder symptoms than those with overt hypothyroidism. Although SCH does not cause significant clinical abnormalities, there are certain long-term consequences which have been documented. The diagnosis is based purely on biochemical investigations. Treatment of this condition is not indicated in all cases since thyroid function tests tend to normalize in 6%–35% of patients. However, there are specific clinical indications for treatment and oral levothyroxine is the treatment of choice in such situations.

Subclinical infection

Levothyroxine

10.4103/cmi.cmi_18_18

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Role of oxidized LDL-induced a(sicoetrained macrophages boolean AND aV in the pathogenesis of COVID-19 and benefits of pioglitazone: A hypothesis

Diabetes & Metabolic Syndrome Clinical Research & Reviews (2021)

Asenjo Sebastián Romi Dasgupta Felix Jebasingh B. Saravanan Binoy Chandy

Pioglitazone

Pathogenesis

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Comprehensive and Cost-Effective Strategy for Genetic Screening of Congenital Adrenal Hyperplasia (CAH) in India

Journal of the Endocrine Society (2021)

Lavanya Ravichandran Sophy Korula Hesarghatta Shyamasunder Asha Deny Varghese Raja Parthiban

Abstract Background: With substantial challenges in molecular analysis of 21 hydroxylase deficiency and lack of studies in extended panel of genes implicated in CAH, genetic diagnosis is largely unavailable and unaffordable in India. Therefore, we aim to develop a cost-effective screening strategy in CAH using Allele Specific PCR and Targeted Next-Generation Sequencing (NGS). Methods: Long range PCR and restriction digestion were utilized to specifically amplify the CYP21A2 gene whereas multiplex PCR was used to amplify CYP11B1, CYP17A1, CYP19A1 and POR genes. In house developed Allele Specific PCR (ASPCR) for 8 hotspot mutations in CYP21A2 gene and targeted NGS for five genes was carried out. The results were validated using Sanger sequencing and MLPA. Results: Of the 50 patients suspected for 21 hydroxylase deficiency, 64% (n=32) were of Salt Wasting phenotype (SW), 30% (n=15) with Simple Virilizing (SV) phenotype and 6% (n=3) of the study population were suspected for non-classical (NC) CAH. The mutation positive rate of ASPCR was 86% (n=43). Seven patients carried more than two biallelic mutations indicating smaller gene conversions. The predominant mutation identified among the study subjects was I2G splice variant in SW phenotype (38%) and I172N in the SV phenotype (41%). Based on the Long range PCR amplification and restriction digestion we identified one patient with large gene conversion and one patient with large 30kb deletion. These results were confirmed with MLPA. Additionally, utilizing the Targeted NGS we identified five patients with CYP21A2 variants (two patients with novel variants c.1274G>T, c.17_18delTG and two other variants in three patients - c.1451G>C, c.143A>G). We also identified a CYP19A1:c.1142A>T gene variant in a patient who was initially suspected for 21 hydroxylase deficiency. Out of six patients with 11 beta hydroxylase deficiency four patients were positive for homozygous CYP11B1 variants (c.1201-1G>A, c.1200 + 1delG, c.412C>T) and two patients with compound heterozygous variants (c.1024C>T and c.1012dupC, c.623G>A and c.412C>T). Discussion: Utilizing the novel allele specific PCR followed by NGS we identified a total of 96% (48/50) of 21 hydroxylase deficiency patients with homozygous or compound heterozygous mutations and 2% (2/50) were positive for single heterozygous variant in CYP21A2 gene. ASPCR followed by multigene targeted NGS assay for genetic screening in CAH has shown to be a sensitive and specific strategy established in a clinical setting. To best of our knowledge this is the most cost-effective and comprehensive multigene screening carried out in India.

Sanger sequencing

21-Hydroxylase

10.1210/jendso/bvab048.1020

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Prevalence and risk factors of pre-senile lens opacities in the 1969-73 Vellore Birth Cohort

Research Square (Research Square) (2023)

Padma Paul Belavendra Antonisamy Neena John Andrew Braganza Thomas Kuri̇akose

Abstract Purpose To estimate the prevalence and determine predictors of lens opacities (LO) among South Asian Indians aged 41-44 years. Methods This cross sectional study included 1080 participants from the Vellore Birth Cohort, Vellore, South India. All individuals underwent anthropometric measurements, detailed ophthalmic examination including assessment of LO by LOCS III classification; and biochemical metabolic measurements. ‘Any cataract’ was defined as any opacity type with a score of >2 or evidence of cataract surgery in either eye. Questionnaire based assessments included information on ocular history, life-style factors, socio-economic and educational status, cooking fuel and sunlight exposure. Multivariable logistic regression analysis was used to examine the association between risk predictors and LO. Results The mean age (SD) of participants was 41.8 (1.0) years; 53.8% were male and 50% were rural residents. The overall prevalence of ‘any cataract’ was 13.8% (148/1075); 95% confidence interval (CI) (11.8,16.0); 59.1% (51.1, 67.4) had nuclear, 16.9% (11.2, 23.9) had cortical, 4.1%(1.5, 8.6) had posterior sub capsular, 18.9% (12.9, 26.2) had mixed cataracts; and 0.7% ( 0.02, 3.7) were pseudophakic. Increased risk for LO was observed with a history of asthma (aOR 4.51; 2.1, 9.7), HbA1C of ≥6.5% (adjusted or aOR 2.29; 95%CI 1.4, 3.7), hypertension (aOR 1.73;1.1, 2.7) and, in a subgroup (n= 372), lower 25(OH) vitamin D levels (≤20 ng/dL)(aOR 5.56; 2.3, 13.2). Conclusions A higher prevalence of LO at a younger age in South Asian Indians predicts earlier onset. History of asthma, higher HbA1C, hypertension and lower 25(OH) vitamin D levels were associated with LO.

Eye examination

10.21203/rs.3.rs-2973292/v1

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Contents

Diabetes Research and Clinical Practice (2019)

Francesco Cosentino Antonio Ceriello G Cattadori Paola Pantanetti Giuseppe Ambrosio

10.1016/s0168-8227(19)31683-3

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