Stacy S. Drury

Tulane University

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i-10 index

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Co-Authors

Robert R. Althoff

University of Vermont

Douglas K. Novins

University of Colorado Anschutz Medical Campus

Tonya White

National Institute of Mental Health

Samuele Cortese

University of Southampton

Jean A. Frazier

University of Massachusetts Chan Medical School

Schuyler W. Henderson

New York University

Elizabeth McCauley

Yale University

Katherine P. Theall

Tulane University

Charles H. Zeanah

Tulane University

John Francis McDermott

Midwestern University

Cooperative Institutions

Tulane University

193

Harvard University

134

Ibero American University

Johns Hopkins University

National Institutes of Health

Columbia University

Regeneron (United States)

University of California, Los Angeles

Massachusetts General Hospital

Emory University

Author Statistics

Papers

Citation

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Research Field

LINE1 DNA methylation is associated with telomere length in African American children

The 84th Annual Meeting of the American Association of Physical Anthropologists, St. Louis, MO (2015)

Karthik Yarlagadda Stacy S. Drury Amy L. Non

Source

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Citations (0)

JoVE Video Dataset

Noelle A. Martin Lauren W. Y. McLester‐Davis Trevor R. Roy Madeline G. Magruder Waylon J. Hastings

Telomeres are ribonucleoprotein structures at the end of all eukaryotic chromosomes that protect DNA from damage and preserve chromosome stability. Telomere length (TL) has been associated with various exposures, biological processes, and health outcomes. This article describes the monochrome multiplex quantitative polymerase chain reaction (MMqPCR) assay protocol routinely conducted in our laboratory for measuring relative mean TL from human DNA. There are several different PCR-based TL measurement methods, but the specific protocol for the MMqPCR method presented in this publication is repeatable, efficient, cost-effective, and suitable for population-based studies. This detailed protocol outlines all information necessary for investigators to establish this assay in their laboratory. In addition, this protocol provides specific steps to increase the reproducibility of TL measurement by this assay, defined by the intraclass correlation coefficient (ICC) across repeated measurements of the same sample. The ICC is a critical factor in evaluating expected power for a specific study population; as such, reporting cohort-specific ICCs for any TL assay is a necessary step to enhance the overall rigor of population-based studies of TL. Example results utilizing DNA samples extracted from peripheral blood mononuclear cells demonstrate the feasibility of generating highly repeatable TL data using this MMqPCR protocol.

10.3791/66545-v

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Virtual stressors with real impact: what virtual reality-based biobehavioral research can teach us about typical and atypical stress responsivity

Translational Psychiatry (2024)

Elizabeth A. Shirtcliff Tor Finseth Eliot Winer David C. Glahn Roselynn A. Conrady

Stress contributes to transdiagnostic morbidity and mortality across a wide range of physical and mental health problems. VR tasks have been validated as stressors with robust effect sizes for VR-based stressors to evoke stress across the most common autonomic and adrenocortical stress biomarkers. However, meta-analytic validation of VR stressors have resulted in inconsistent logic: why should something that isn't real evoke a very real suite of stress responses? This review posits that conceptually addressing this question requires differentiating a cause, "stressor", from effects, "stress". Stress comprises a series of well-delineated perturbations in biological systems, such as autonomic and adrenocortical biomarkers in response to stressors. Despite their ubiquity, decades of literature have back-calculated stressor intensity based on the magnitude of a stress response. This causal directionality is not logical, yet remains pervasive because seemingly objective stress indices have generated a wealth of findings showing how stress gets under the skin and skull. This has created challenges for providing clear guidance and strategies to measure acute stressor intensity. Binary thinking about whether something is (not) real has stifled advances in understanding how to measure the dosage of a stressful environment. As a function of being programmed, individualizable, and titrated, virtual reality (VR) based stressors offer the field a platform for quantifying the dose of a stressor and generating reliable dose-response curves. This also raises the possibility to safely and ethically integrate psychosocial stressor administration into clinical and therapeutic settings. For example, Social Evaluative Threat experiments effectively trigger a stress response both in a laboratory setting and in built environments, while also upholding hard-fought trust and rapport with care providers. By focusing attention on the measurement of the stressor, VR paradigms can advance tangible understanding of stressors themselves and the pathways to the stress response.

Stressor

10.1038/s41398-024-03129-x

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Citations (0)

A Randomized Controlled Trial Comparing Foster Care and Institutional Care for Children With Signs of Reactive Attachment Disorder

American Journal of Psychiatry (2012)

Anna T. Smyke Charles H. Zeanah Mary Margaret Gleason Stacy S. Drury Nathan A. Fox

Objective: The authors examined signs of emotionally withdrawn (inhibited type) and indiscriminately social (disinhibited type) reactive attachment disorder in Romanian children enrolled in a randomized trial of foster care compared with institutional care and in a comparison group of never-institutionalized children. Method: At baseline and when children were ages 30, 42, and 54 months and 8 years, caregivers were interviewed with the Disturbances of Attachment Interview to assess changes in signs of reactive attachment disorder in three groups of children: those receiving care as usual (including continued institutional care) (N=68); those placed in foster care after institutional care (N=68); and those who were never institutionalized (N=72). The impact of gender, ethnicity, and baseline cognitive ability was also examined. Results: On the Disturbances of Attachment Interview, signs of the inhibited type of reactive attachment disorder decreased after placement in foster care, and scores were indistinguishable from those of never-institutionalized children after 30 months. Signs of the disinhibited type were highest in the usual care group, lower in the foster care group, and lowest in the never-institutionalized group. Early placement in foster care (before age 24 months) was associated with fewer signs of the disinhibited type. Lower baseline cognitive ability was associated with more signs of the inhibited type in the usual care group and more signs of the disinhibited type in both groups. Conclusions: Signs of the inhibited type of reactive attachment disorder responded quickly to placement in foster care; signs of the disinhibited type showed less robust resolution with foster placement. Lower baseline cognitive ability was linked to signs of reactive attachment disorder.

Foster Home Care

10.1176/appi.ajp.2011.11050748

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Citations (161)

Editorial Board

Journal of the American Academy of Child & Adolescent Psychiatry (2020)

Douglas K. Novins Robert R. Althoff Samuele Cortese Stacy S. Drury Jean A. Frazier

10.1016/s0890-8567(20)30293-8

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Citations (0)

In This Issue/Abstract Thinking: Inside the Adolescent Brain

Journal of the American Academy of Child & Adolescent Psychiatry (2009)

Stacy S. Drury Jay N. Giedd

Brain Development

Adolescent Development

10.1097/chi.0b013e3181a5e413

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Citations (1)

Telomere length measurement by qPCR – Summary of critical factors and recommendations for assay design

Psychoneuroendocrinology (2018)

Jue Lin Dana L. Smith Kyle Esteves Stacy S. Drury

Buccal swab

10.1016/j.psyneuen.2018.10.005

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Citations (132)

Serotonin Transporter Genotype (5HTTLPR) Moderates the Longitudinal Impact of Atypical Attachment on Externalizing Behavior

Journal of Developmental & Behavioral Pediatrics (2015)

Kathryn L. Humphreys Charles H. Zeanah Charles A. Nelson Nathan A. Fox Stacy S. Drury

To test whether genotype of the serotonin transporter-linked polymorphic region (5HTTLPR) and atypical attachment interact to predict externalizing psychopathology prospectively in a sample of children with a history of early institutional care.Caregiver report of externalizing behavior at 54 months was examined in 105 children initially reared in institutional care and enrolled in the Bucharest Early Intervention Project, a randomized controlled trial of high quality foster care. 5HTTLPR genotype, attachment status at 42 months of age (typical [secure, avoidant, or ambivalent] or atypical [disorganized-controlling, insecure-other]), and their interaction were examined as predictors of externalizing behavior at age 54 months.5HTTLPR genotype and atypical attachment at age 42 months interacted to predict externalizing behavior at age 54 months. Specifically, children with the s/s genotype with an atypical attachment had the highest externalizing scores. However, s/s children with a typical attachment demonstrated the lowest externalizing scores, even after controlling for intervention group status. There was no association between attachment status and externalizing behavior among children carrying at least 1 copy of the l allele.These findings indicate that genetic variation in the serotonergic system moderates the association between atypical attachment status and externalizing in young children. Our findings suggest that children, as a result of genetic variability in the serotonergic system, demonstrate differential sensitivity to the attachment relationship.

Association (psychology)

10.1097/dbp.0000000000000171

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Citations (18)

5.3 The Association Between Maternal Adverse Childhood Experience and Maternal Depression: A Longitudinal Cohort Study

Journal of the American Academy of Child & Adolescent Psychiatry (2018)

Jasmine E. Kim Tegan N. Clarke Christopher W. Jones Stacy S. Drury

Depression

Longitudinal Study

Adverse Childhood Experiences

Association (psychology)

10.1016/j.jaac.2018.09.298