Mengting Yan

Nanjing Agricultural University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Lifan Zhang

China University of Mining and Technology

Wei Wei

Nanjing Agricultural University

Weimin Lin

University of Cambridge

Jie Chen

Guilin Medical University

Xiangsheng Lin

Nanjing Agricultural University

Shaoru Li

Xi'an Jiaotong University

Kai Yang

State Key Laboratory of Respiratory Disease

Kai Yang

Shandong Academy of Sciences

Wei Wei

Chinese Academy of Medical Sciences & Peking Union Medical College

Yuchen Ma

Shandong University

Cooperative Institutions

Nanjing Agricultural University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sichuan University

Shandong University

Capital Medical University

West China Hospital of Sichuan University

Anhui Normal University

Wenzhou Medical University

First Affiliated Hospital of Xinxiang Medical University

Tongji University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

SESN3 Inhibited SMAD3 to Relieve Its Suppression for MiR-124, Thus Regulating Pre-Adipocyte Adipogenesis

Genes (2021)

Weimin Lin Jindi Zhao Mengting Yan Xuexin Li Kai Yang

Sestrin-3, together with the other two members Sestrin-1 and Sestrin-2, belongs to the Sestrin family. The Sestrin protein family has been demonstrated to be involved in antioxidative, metabolic homeostasis, and even the development of nonalcoholic steatohepatitis (NASH). However, the adipogenic regulatory role of SESN3 in adipogenesis still needs to be further explored. In this study, we demonstrated SESN3 inhibited porcine pre-adipocyte proliferation, thus suppressing its adipogenesis. Meanwhile, SESN3 has been demonstrated to inhibit Smad3 thus protecting against NASH. Further, for our previous study, we found mmu-miR-124 involved in 3T3-L1 cell adipogenesis regulation. In this study, we also identified that ssc-miR-124 inhibited porcine pre-adipocyte proliferation, thus suppressing its adipogenesis, and the SMAD3 was an inhibitor of ssc-miR-124 by binding to its promoter. Furthermore, the ssc-miR-124 targeted porcine C/EBPα and GR and thus inhibited pre-adipocyte adipogenesis. In conclusion, SESN3 inhibited SMAD3, thus improving ssc-miR124, and then suppressed C/EBPα and GR to regulate pre-adipocytes adipogenesis.

Nonalcoholic steatohepatitis

10.3390/genes12121852

Cite

Citations (7)

MiR-218-5p Affects Subcutaneous Adipogenesis by Targeting ACSL1, a Novel Candidate for Pig Fat Deposition

Genes (2022)

Baosen Shan Mengting Yan Kai Yang Weimin Lin Jiayu Yan

As a centre enzyme in fatty acid activation, acyl-CoA synthetase long-chain family member 1 (ACSL1) plays an important role in body lipid homeostasis. However, the functions of ACSL1 in the subcutaneous adipogenesis of pigs are largely unknown. In the present study, we found that the expression of ACSL1 significantly increased during the process of porcine preadipocyte differentiation. Moreover, silencing of ACSL1 in preadipocytes decreased levels of triglyceride and adipogenic-related markers, including FABP4, APOE, and FASN (p < 0.01), and simultaneously increased levels of lipolytic-related markers, such as ATGL and HSL (p < 0.05). Conversely, overexpression of ACSL1 in preadipocytes increased levels of triglyceride and FABP4, APOE, and FASN (p < 0.01), and reduced levels of ATGL and HSL (p < 0.05). Luciferase reporter assays revealed that ACSL1 is a target of miR-218-5p, which can reduce the mRNA and protein levels of ACSL1 by directly binding the 3′ untranslated region of ACSL1. Furthermore, miR-218-5p has an inhibition role in porcine preadipocyte differentiation by suppressing ACSL1 expression. Taken together, these data provide insights into the mechanism of the miR-218-5p/ACSL1 axis in regulating subcutaneous fat deposition of pigs.

Subcutaneous fat

Deposition

10.3390/genes13020260

Cite

Citations (10)

Hoxa11 and Hoxa13 facilitate slow‐twitch muscle formation in C2C12 cells and indirectly affect the lipid deposition of 3T3‐L1 cells

Animal Science Journal (2021)

Xiangsheng Lin Mengting Yan Wensai Yu Yuchen Ma Lifan Zhang

Abstract Muscle‐fiber type in livestock skeletal muscles influences meat quality, but the underlying mechanisms remain unclear. We previously showed that Homeobox A11 (Hoxa11) and Homeobox A13 ( Hoxa13) are differentially expressed in fast‐ and slow‐twitch muscles, but their effects on the formation of muscle‐fiber types and intramuscular fat deposition have not been investigated. Here, our results revealed that overexpression of Hoxa11 and Hoxa13 delayed cell‐cycle progression in C2C12 myoblasts, reduced their proliferation, and promoted their differentiation into slow‐twitch muscle fibers. Knockdown experiments produced the opposite results. The conditioned media of differentiated C2C12 cells with Hoxa11 / Hoxa13 overexpression or knockdown were harvested. Staining results showed that adipogenesis of preadipocytes was significantly promoted by Hoxa13 knockdown C2C12 cell culture medium. Changes in lipid accumulation were due to a reduction in lipid decomposition and an increase in triglyceride synthesis; genes related to fatty‐acid synthesis were decreased. In conclusion, our study showed that Hoxa11 and Hoxa13 promote slow‐twitch muscle formation and indirectly regulate preadipocyte adipogenesis, which may facilitate meat‐quality improvement in the future.

C2C12

10.1111/asj.13544

Cite

Citations (3)

LncRNA SNHG20 promotes cell proliferation and invasion via miR-140-5p-ADAM10 axis in cervical cancer

Biomedicine & Pharmacotherapy (2018)

Huimin Guo Sheng‐Hua Yang Shaoru Li Mengting Yan Li Li

ADAM10

10.1016/j.biopha.2018.03.024

Cite

Citations (78)