Ockyoung Chang

Chonnam National University

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Young‐Woo Seo

University of Toledo

Yongfeng He

Weill Cornell Medicine

Jeong Ran Han

Korea Atomic Energy Research Institute

Kwonseop Kim

Chonnam National University

Minsoo Oh

Chonnam National University

Qun Lu

Tianjin Medical University General Hospital

Sarah E. James

Mayo Clinic in Florida

Hangun Kim

Sunchon National University

Qun Lu

Air Force Medical University

Kwonseop E. Kim

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Chonnam National University

East Carolina University

Capital Medical University

University of Toledo

Korea Basic Science Institute

Seoul National University of Science and Technology

Korea Research Institute of Bioscience and Biotechnology

University of Cincinnati

LG (United States)

Mayo Clinic in Florida

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14‐3‐3ɛ/ζ Affects the stability of δ‐catenin and regulates δ‐catenin‐induced dendrogenesis

FEBS Open Bio (2012)

Yongfeng He Jeong Ran Han Ockyoung Chang Minsoo Oh Sarah E. James

Accumulated evidence suggests that aberrant regulation of δ-catenin leads to pathological consequences such as mental retardation and cognitive dysfunction. This study revealed that 14-3-3ɛ/ζ stabilizes δ-catenin, with different binding regions involved in the interaction. Furthermore, the specific inhibition of the interaction of 14-3-3 with δ-catenin reduced levels of δ-catenin and significantly impaired the capacity of δ-catenin to induce dendritic branching in both NIH3T3 fibroblasts and primary hippocampal neurons. However, the S1094A δ-catenin mutant, which cannot interact with 14-3-3ζ, still retained the capability of inducing dendrogenesis. Taken together, these results elucidate the underlying events that regulate the stability of δ-catenin and δ-catenin-induced dendrogenesis.

Beta-catenin

10.1016/j.fob.2012.11.006

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δ-Catenin Affects the Localization and Stability of p120-Catenin by Competitively Interacting with E-Cadherin

Molecules and Cells (2010)

Ilhwan Yang Ockyoung Chang Qun Lu Kwonseop Kim

E-cadherin is a member of the cadherin family of Ca2+-dependent cell-cell adhesion molecules. p120-Catenin and δ-catenin are known to bind to similar juxtamembrane regions of E-cadherin, and p120-catenin is known to stabilize E-cadherin. However, the function of competition between p120-catenin and δ-catenin for E-cadherin has not been fully explained. In this report, we show that cells overexpressing δ-catenin contain less p120-catenin than control cells at the cell-cell interface and that this causes the relocalization of p120-catenin from the plasma membrane to the cytosol. We show that successful binding by one to E-cadherin adversely affects the stability of the other.

10.1007/s10059-010-0030-2

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Citations (18)

14-3-3?/? Affects the stability of d-catenin and regulates d-catenin-induced dendrogenesis

Ockyoung Chang Jeong Ran Han Yongfeng He Sarah James Kwonseop E. Kim

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