Abstract This study analyzes how the beta index, which is closely related to alertness, caution, concentration, anxiety, and tension in brain activity, varies before and after practicing yoga. Electroencephalogram (EEG) and subjective evaluations were conducted on healthy female yoga trainers with over three years of experience; participants wore yoga clothes with differing characteristics in a hot environment. Repeated ANOVA measurements were conducted on the data by deriving the difference between the corresponding sample t-test pre- and post-yoga. After yoga, concentration increased, while alertness, anxiety, and excitement decreased depending on the yoga clothes. The clothing combination that offered higher pressure and greater absorption, and enhanced concentration while lowering excitation and anxiety increased beta waves the most. The design characteristics of yoga clothes influence beta power for concentration and arousal after yoga practice. Through EEG measurements, it was possible to explore the mental states resulting from wearing clothes suitable for yoga.
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disorder which affects small- and, to a lesser degree, medium-sized vessels. ANCA-associated vasculitis encompasses three disease phenotypes: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). This classification is largely based on clinical presentations and has several limitations. Recent research provided evidence that genetic background, risk of relapse, prognosis, and co-morbidities are more closely related to the ANCA serotype, proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA, compared to the disease phenotypes GPA or MPA. This finding has been extended to the investigation of biomarkers predicting disease activity, which again more closely relate to the ANCA serotype. Discoveries related to the immunopathogenesis translated into clinical practice as targeted therapies are on the rise. This review will summarize the current understanding of the immunopathogenesis of ANCA-associated vasculitis and the interplay between ANCA serotype and proposed disease biomarkers and illustrate how the extending knowledge of the immunopathogenesis will likely translate into development of a personalized medicine approach in the management of ANCA-associated vasculitis.
This paper examines the extent to which taxes affect internal versus external leverage by focusing on wholly-owned subsidiaries in Korea. Foreign subsidiaries are under classical system where double taxation of corporate and personal income provides interest tax shields, while domestic subsidiaries are under imputation system where such distortion between debt and equity is largely eliminated. We find that foreign subsidiaries do not exhibit higher overall leverage than domestic subsidiaries controlling for various firm characteristics. On the other hand, foreign subsidiaries exhibit higher internal leverage than domestic subsidiaries. We also find that foreign subsidiaries with excess foreign tax credit status use more internal debt when home country corporate tax rate is low. These findings suggest that taxes have first order impact on internal debt when marginal investor holds both debt and equity, but not on external debt possibly due to limited substitutability of comparable debt instruments.
Abstract This study quantitatively analyzes the data of 3D seam shapes that alter according to easing conditions. By numerically approaching easing, which is only taught using traditional methods, this study suggests a method of analyzing the changes in 3D surface area, volume, and seam shape. The 3D data of the completed samples were obtained through a 3D scanner, the solid shapes were analyzed using reverse engineering, and a new program was developed. The shape, area, and volume of the data were analyzed, and the deformation rate was measured using the radius of curvature. Linear seam lines were bent because of the mechanical pushing inflicted by the garment with easing. The area increased dramatically as the ease amount increased when the seam lines were short, whereas it was relatively unaffected when seam lines were long. The radii of curvature for curved seam lines show that, for all samples, the waveform is high at the center where the seam is. The peak value did not increase for curved seams when the ease amount increased. The sum of the areas increased with a larger radius of curvature for the curved seams. It is a crucial reference for easing in garments regarding quantitative changes in seam shapes and volumes according to easing type and amount.
This study evaluated the effect of functional characteristics of the fabric for Bikram yoga clothing and fit measured in clothing pressure on the wearer''s physiological response and perceptive sensation before and after exercise in hot conditions and during a resting period in standard conditions. The test garment consisted of two tops (T1, T2) and two pants (P1, P2) each with different functional characteristics of fabric. Using various combinations of the test garments, assessment of the thermal sensation and comfort was performed before/after yoga and after resting. This study revealed that thermal sensation and wearing comfort significantly changed based on the functionality of the fabric of top garment before the exercise period. In addition, the results showed that based on clothing pressure, the feeling of comfort was different between before yoga and after resting. The appropriate choice of fabric material was important when constructing Bikram yoga clothing worn in hot conditions; however, level of clothing pressure was also found to be an essential design factor for comfort during rest after exercise.
Simultaneous induction of other types of programmed cell death, alongside apoptosis, in cancer cells may be considered an attractive strategy for the development of more effective anticancer therapies. The present study aimed to investigate the role of AMP‑activated protein kinase (AMPK) in nutrient/serum starvation‑induced necroptosis, which is a programmed form of necrosis, in the presence or absence of p53. The present study detected higher cell proliferation and lower cell death rates in the HCT116 human colon cancer cell line containing a p53 null mutation (HCT116 p53‑/‑) compared with in HCT116 cells harboring wild‑type p53 (HCT116 p53+/+), as determined using a cell viability assay. Notably, western blot analysis revealed a relatively lower level of necroptosis in HCT116 p53‑/‑ cells compared with in HCT116 p53+/+ cells. Investigating the mechanism, it was revealed that necroptosis may be induced in HCT116 p53+/+ cells by significantly increasing reactive oxygen species (ROS) and decreasing mitochondrial membrane potential (MMP), whereas little alterations were detected in HCT116 p53‑/‑ cells. Unexpectedly, a much lower level of ATP was detected in HCT116 p53‑/‑ cells compared with in HCT116 p53+/+ cells. Accordingly, AMPK phosphorylation on the Thr172 residue was markedly increased in HCT116 p53‑/‑ cells. Furthermore, western blot analysis and ROS measurements indicated that AMPK inhibition, using dorsomorphin dihydrochloride, accelerated necroptosis by increasing ROS generation in HCT116 p53‑/‑ cells. However, AMPK activation by AICAR did not suppress necroptosis in HCT116 p53+/+ cells. In conclusion, these data strongly suggested that AMPK activation may be enhanced in HCT116 p53‑/‑ cells under serum‑depleted conditions via a drop in cellular ATP levels. In addition, activated AMPK may be at least partially responsible for the inhibition of necroptosis in HCT116 p53‑/‑ cells, but not in HCT116 p53+/+cells.
Purpose : The purpose of this study was to evaluate the influence of Lowenstein Occupational Therapy Cognitive Assessment(LOTCA) and Activities of Daily Living(ADL) by CogPack program in elderly with Alzheimer's dementia. Method : The subjects of this study, elderly diagnosed with Alzheimer's dementia, 8 patients were picked up, who were agreed with this research. Cognitive training for 6 weeks, which consisted of 3 times per week, 30 min of memory, attention and performance with cogpack program. Cognitive and ADL measured by LOTCA and FIM. The SPSS Ver. 14.0 statistical program was used for data processing. The significance level for statistical inspection was set as 0.05. Result : In comparison of LOTCA was significantly correlated in the pre and post test but FIM was not significantly correlated in the pre and post test. Conclusion : Therefore, the CogPack program is useful to improve the LOTCA in elderly with Alzheimer's dementia.
This study aimed to quantitatively determine an appropriate size-margin for activities based on the analysis of existing products to improve the mobility of jumpers among the items worn by construction workers. In this study, four types of currently available spring/autumn jumpers and winter jumpers worn by construction workers were collected, and their size specifications were examined. After wearing the jumpers, the subjects evaluated the jumpers’fit and margin for movement. The average chest circumference of the collected spring/autumn jumpers was 113.4 cm, and that of the winter jumpers was 116.2 cm. The winter jumpers had ribs around the sleeves and hems. Both types of jumpers showed significant differences in the “comfort level” with motion for the sleeves and cuffs in the subjective fit evaluation; furthermore, the winter jumpers also had significant differences in the hem circumference. We found that in the design of construction work jumpers, the pattern and dimension of the sleeves affecting arm movement we revery important specifications, regardless of the season. Furthermore, the circumference of the hem, which can be pulled up by the movement of the arms and waist, is a sensitive part of the fit evaluation. It was confirmed that the dimension specifications for the ease of workwear should be changed according to the season, and the ease for work derived from this study were as follows: 20.0 cm for the chest circumference, 26.0 cm for the hem circumference, 15.8 cm for the sleeve circumference, and 5.6 cm for the cuff circumference, for the spring/autumn jumpers, and 19.5 cm for the chest circumference, 4.0 cm (28.0 cm for maximum height)forthe hem circumference with ribs, 13.8 cm for the sleeve circumference, and -0.4 cm(15.6 cm for maximum height) for the cuff circumference with ribs, for the winter jumpers.
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