Maryam Pourashraf

Imam Khomeini Hospital

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Nasrin Ahmadinejad

Imam Khomeini Hospital

Maryam Rahmani

Tehran University of Medical Sciences

Mahrooz Malek

Tehran University of Medical Sciences

Narges Zamani

Tehran University of Medical Sciences

Samira Raminfard

Tehran University of Medical Sciences

Maryam Farsi

Imam Khomeini Hospital

Behzad Amanpour-Gharaei

Tehran University of Medical Sciences

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Imam Khomeini Hospital

Tehran University of Medical Sciences

University of Tehran

Advanced Diagnostic and Interventional Radiology Research Center

University of Auckland

University of California, Irvine

Tawam Hospital

Khalifa University of Science and Technology

Children's Medical Center

Kerman University of Medical Sciences

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Prediction of lymphovascular space invasion in cervical carcinoma using diffusion kurtosis imaging

Cancer Treatment and Research Communications (2022)

Mahrooz Malek Maryam Rahmani Maryam Pourashraf Behzad Amanpour-Gharaei Narges Zamani

This study aimed to investigate the potential relationship between diffusion kurtosis imaging (DKI)- derived parameters and lymphovascular space invasion (LVSI) in patients with cervical carcinoma. This prospective study included 30 patients with cervical carcinoma. The patients underwent MRI, diffusion-weighted imaging (DWI), and DKI prior to surgery. The surgical pathology results were accepted as the reference standard for determining the LVSI status. The DKI-derived parameters, including mean diffusivity (MD) and mean kurtosis (MK), were measured. The apparent diffusion coefficient (ADC) value was also assessed. The MD value of LVSI positive cervical carcinomas was significantly lower than LVSI negative carcinomas (p-value = 0.01). MK value was significantly higher in LVSI positive tumors (p-value = 0.01). However, the ADC value did not show a significant difference between LVSI positive and LVSI negative tumors (p-value = 0.2). MD and MK parameters showed similar diagnostic accuracy in identifying the LVSI status, with the area under the curve of 0.77 and 0.78, respectively. In this study, DKI-derived parameters were associated with the LVSI status in cervical carcinomas. Further studies with larger sample size are required to confirm these results.

Kurtosis

10.1016/j.ctarc.2022.100559

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