R Al Khatib

Université de Lille

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Sevser Şahpaz

Université de Lille

Bruno Quesnel

Université de Lille

Thierry Idziorek

Inserm

Thierry Hennebelle

Université de Lille

Claude Preudhomme

Inserm

Sami Joha

Université Lille Nord de France

F. Bailleul

Université de Lille

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Université de Lille

Centre National de la Recherche Scientifique

Inserm

Institut Pasteur de Lille

Université Lille Nord de France

Institut pour la Recherche sur le Cancer de Lille

Centre de Recherche Jean Pierre Aubert

Institut Charles Viollette

Centre Hospitalier Universitaire de Lille

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CANTHER - Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers

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New sesquiterpene esters and a saponin from Ferula elaeochytris and their cytotoxic evaluation against leukemia cell lines

Planta Medica (2008)

R Al Khatib Thierry Hennebelle Sami Joha Thierry Idziorek Claude Preudhomme

Ferula elaeochytris Korovin (Apiaceae) is a species found in Turkey and Syria. A previous phytochemical work led to the isolation of several compounds [1], among which ferutinin was shown later to have antiproliferative and cytotoxic properties, on estrogene-dependent [2] or independent [3,4] tumor cell lines. We undertook a new phytochemical investigation of a root methanolic extract that lead to the isolation of three new compounds: two sesquiterpene esters, elaeochytrin A (6-anthraniloyljaeschkeanadiol) and elaeochytrin B (4β-hydroxy-6α-(p-hydroxybenzoyloxy)dauc-9-ene) and a saponin, ferulasaponin (3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranuronyl-(1→2)-β-D-glucopyranosyl]-28-O-glucopyranosyl oleanolic acid).

Phytochemical

Apiaceae

10.1055/s-0028-1084360

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