Masataka Taniuchi

Osaka University of Pharmaceutical Sciences

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Ryo Kawata

Osaka University of Pharmaceutical Sciences

Tetsuya Terada

Osaka University of Pharmaceutical Sciences

Masaaki Higashino

Osaka University of Pharmaceutical Sciences

Teruhito Aihara

Osaka University of Pharmaceutical Sciences

Tsuyoshi Jinnin

Osaka University of Pharmaceutical Sciences

Yoshinobu Hirose

Osaka University of Pharmaceutical Sciences

Takaki Inui

Osaka University of Pharmaceutical Sciences

Hiromi Nishimura

Osaka University of Pharmaceutical Sciences

Ichita Kinoshita

Osaka University of Pharmaceutical Sciences

Yoshitaka Kurisu

Osaka University of Pharmaceutical Sciences

Cooperative Institutions

Osaka Medical and Pharmaceutical University

Osaka University of Pharmaceutical Sciences

Rakuwakai Otowa Hospital

Saiseikai Nakatsu Hospital

Niigata University

Tohoku University

Osaka University

Weatherford College

Tokushima University

Kansai Medical University

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Increased Chymase-Positive Mast Cells in High-Grade Mucoepidermoid Carcinoma of the Parotid Gland

International Journal of Molecular Sciences (2023)

Hiromi Nishimura Denan Jin Ichita Kinoshita Masataka Taniuchi Masaaki Higashino

It has long been known that high-grade mucoepidermoid carcinoma (MEC) has a poor prognosis, but the detailed molecular and biological mechanisms underlying this are not fully understood. In the present study, the pattern of chymase-positive mast cells, as well as chymase gene expression, in high-grade MEC was compared to that of low-grade and intermediate-grade MEC by using 44 resected tumor samples of MEC of the parotid gland. Chymase expression, as well as chymase-positive mast cells, was found to be markedly increased in high-grade MEC. Significant increases in PCNA-positive cells and VEGF gene expression, as well as lymphangiogenesis, were also confirmed in high-grade MEC. Chymase substrates, such as the latent transforming growth factor-beta (TGF-β) 1 and pro-matrix metalloproteinase (MMP)-9, were also detected immunohistologically in high-grade MEC. These findings suggested that the increased chymase activity may increase proliferative activity, as well as metastasis in the malignant condition, and the inhibition of chymase may be a strategy to improve the poor prognosis of high-grade MEC of the parotid gland.

Chymase

10.3390/ijms24098267

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Fine-Needle Aspiration Cytology for Parotid Tumors

Life (2022)

Masataka Taniuchi Tetsuya Terada Ryo Kawata

Fine-needle aspiration (FNA) cytology is widely used in clinical practice as a simple and minimally invasive test for parotid tumors that allows for preoperative estimation of benignancy and malignancy, histological type, and malignancy grade and can be performed on an outpatient basis. In recent years, cell blocks prepared with core needle biopsy (CNB) and liquid-based cytology (LBC) have increased the reliability of immunostaining and molecular biological testing, leading to improved diagnostic accuracy. In 2018, the Milan System for Reporting Salivary Gland Cytology was introduced, but it does not include malignancy grade or histological type, so we proposed the Osaka Medical College classification as a more clinically based cell classification that includes both types of information, and we have reported on its usefulness. This review gives an overview of the history and use of FNA and describes CNB and LBC and the two classification systems.

10.3390/life12111897

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A Case of Masticatory Muscle Tendon Aponeurosis Hyperplasia with Severe Opening Disorder at Laryngeal Microsurgery

Koutou (THE LARYNX JAPAN) (2020)

Eisuke Suzuki Masaaki Higashino Masataka Taniuchi Norio Suzuki Ryo Kawata

We experienced a case in which laryngeal deployment was difficult due to an unexpected opening disorder during laryngeal microsurgery for laryngeal tumors. The patient was a 39-year-old man, and the jaws were preoperatively examined. After intravenous anesthesia with no history of arthropathy and no dental damage, opening obstruction was noted, but we were still able to perform intubation using a McGRATH® tube．Although the opening was about 15 mm in size, it was difficult to deploy a laryngeal microscope. The tissue was collected transnasal using a biopsy and nasal fiberscope with forceps. After the removal of the intubation tube, the opening improved to 25 mm. Characteristic square mandible face was noted, and the cause of the opening disorder was thought to be masticatory muscle tendon aponeurosis hyperplasia. We herein report this case，including some considerations from the literatures.

Aponeurosis

Fiberscope

10.5426/larynx.32.58

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Clinical Outcomes of Treatment for Thyroid Cancer at Osaka Medical and Pharmaceutical University: A 24-year Experience

Practica oto-rhino-laryngologica Suppl (2024)

Masataka Taniuchi Ryo Kawata Tetsuya Terada Masaaki Higashino Teruhito Aihara

We evaluated the management and outcomes of patients with thyroid cancer treated at our department between September 1999 and March 2023. Data of a total of 586 patients were analyzed. When classified according to the histopathology, papillary thyroid carcinoma and poorly differentiated carcinoma accounted for 380 and 143 cases, respectively. We performed total thyroidectomy in the high-risk group, and hemi-thyroidectomy in the low-/intermediate-risk group. Central neck dissection was performed in all cases; ipsilateral dissection with hemithyroidectomy, and bilateral dissection with total thyroidectomy. Selective neck dissection (level II to V) was the standard treatment for patients with lateral node positivity. The 5-year disease-specific survival (DSS) rate was 98.5% in the group with papillary thyroid carcinoma, and 90.6% in the group with poorly differentiated carcinoma. In the patient group with papillary thyroid carcinoma, the 5-year DSS was almost 100%, irrespective of the T and N stages. In the patient group with poorly differentiated carcinoma, the 5-year DSS rate was especially poor in the patients with advanced-stage disease who were over 55 years old. One of the most controversial issues in the treatment of thyroid cancer is the management of the central neck nodes in patients who are clinically node-negative. We concluded that prophylactic central neck dissection should be performed in all cases, because of the high pathological node-positive rate in the level VI lymph nodes.

Cancer Treatment

10.5631/jibirinsuppl.165.33

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Central node dissection from the perspective of lateral neck node metastasis in papillary thyroid carcinoma

Auris Nasus Larynx (2023)

Masataka Taniuchi Ryo Kawata Tetsuya Terada Masaaki Higashino Teruhito Aihara

Neck dissection

T-stage

10.1016/j.anl.2023.10.003

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Generational Study of Laryngeal Cancer Cases―Comparison of Middle-Aged, Early-Stage Elderly and Late-Stage Elderly Patients―

Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo) (2021)

Masaaki Higashino Masataka Taniuchi Tsuyoshi Jinnin Shuji Omura Shuji Nishikawa

喉頭癌患者の世代別の臨床像と治療法について比較検討を行った. 1999～2017年までに大阪医科大学耳鼻咽喉科・頭頸部外科で初回治療を行った喉頭癌400例を対象とし, 64歳以下を壮年者, 65歳以上74歳以下を前期高齢者, 75歳以上を後期高齢者と定義した. それら3群で臨床像 (病期, 治療方針, 治療成績) を比較した. さらに前半200例と後半200例を比較した. 声門癌では病期に世代差は認めず, 声門上癌では壮年者において, N+ 症例が有意に多かった. 声門癌, 声門上癌ともに後期高齢者で RT 単独例が多かった. 治療成績は世代差を認めなかった. BSC 症例は前期高齢者以降で有意に多くなり, 男性より女性に多かった. 前半200例より後半200例では平均年齢が3.1歳上昇していた. 治療方針において, 壮年者では喉頭全摘から CDDPRT に移行し, 後期高齢者では変わらず RT 単独が最も多く, 喉頭全摘が減少した. しかし, 前半200例と後半200例ではほぼ同等の生存曲線であった. 喉頭癌患者の平均年齢が上昇し, 全世代で喉頭温存を重視する治療方針に変化していた. しかし, 疾患特異的生存率に変化は見られなかった. 高齢がん患者の健康状態はさまざまであるため, 病期だけでなく, 全身状態を見定めて, BSC も含めた治療方針を決定していく必要がある.

Cancer stage

10.3950/jibiinkotokeibu.124.8_1179

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A novel clinically-oriented classification of fine-needle aspiration cytology for salivary gland tumors: a 20-year retrospective analysis of 1175 patients

International Journal of Clinical Oncology (2020)

Masataka Taniuchi Ryo Kawata Shuji Omura Shin- Ichi Haginomori Tetsuya Terada

Abstract Background When determining treatment strategy for a salivary gland tumor, assessing histology and malignancy grade before surgery is essential. Several new diagnostic classification systems for salivary gland cytology have recently been proposed. However, none incorporate histology and grade of malignancy. Methods We developed a new cytology classification system that incorporates histology and grade of malignancy of salivary gland tumors (OMC classification), consisting of 11 categories. Our OMC classification was applied to 1175 patients who had preoperative cytology and confirmed final pathological diagnosis available from the past 20 years at our hospital (benign tumor: 981 patients, malignant tumor: 194 patients). Results Based on the cytology, 729 patients (62.0%) had benign histology (Category 4–1), and 87 patients (7.4%) were diagnosed with grade of malignancy (Category 6–3 + 6–4). Based on the final pathological diagnosis, the accuracy rate of Category 4–1 and Category 6–3 + 6–4 of our classification system was 93.4% and 88.5%, respectively. Conclusion Based on the correct diagnosis rate, the inclusion of histology and grade of malignancy in the salivary gland cytology classification was considered feasible. Thus, the OMC classification system is considered a useful tool when determining the treatment strategy for a salivary gland tumor.

Histology

Surgical oncology

10.1007/s10147-020-01816-5

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A Case of Posterior Reversible Encephalopathy Syndrome Caused by Combined 5-FU Plus Cisplatin Chemotherapy Used for Recurrent Maxillary Cancer

Practica Oto-Rhino-Laryngologica (2018)

Masataka Taniuchi Tetsuya Terada Tatsuro Kuriyama Takaki Inui Ryo Kawata

We report a case of posterior reversible encephalopathy syndrome (PRES) caused by 5-FU plus cisplatin therapy.

10.5631/jibirin.111.409

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Epistaxis in Hereditary Hemorrhagic Telangiectasia: Three Cases Requiring Hospitalization

Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology) (2022)

Tsuyoshi Jinnin Takaki Inui Tetsuya Terada Eisuke Suzuki Masataka Taniuchi

オスラー病は遺伝性出血性毛細血管拡張症(Hereditary hemorrhagic telangiectasia: HHT)とも呼ばれ,常染色体顕性遺伝,皮膚や多臓器の多発性毛細血管拡張,反復する鼻出血を3主徴とする多臓器疾患である。当科で鼻出血の制御を目的として入院加療を要したHHT患者3例を経験したため,その治療内容や経過をまとめ報告する。

10.7248/jjrhi.61.131

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Management and outcome of parotid mucoepidermoid carcinoma by histological grade: A 21‐year review

Laryngoscope Investigative Otolaryngology (2022)

Masataka Taniuchi Ryo Kawata Tetsuya Terada Masaaki Higashino Hiromi Nishimura

Abstract Objective Mucoepidermoid carcinoma (MEC) is the most common malignancy of the parotid gland, but the outcome depends on the histological grade. Therefore, the aim of this study was to evaluate MEC on the basis of histological grade. Study Design Retrospective analysis. Methods We performed a retrospective analysis of data from patients whose initial treatment for MEC of the parotid gland was performed at our department between 1999 and 2021. We examined the association between the Armed Forces Institute of Pathology (AFIP) grade and outcome. Results The AFIP grades were as follows: low, 26 cases; intermediate, 9 cases; and high, 31 cases. About 50% of cases were correctly diagnosed as malignant, and both grade and histology were accurately determined by fine‐needle aspiration cytology in 20% of cases. The 5‐year disease‐free survival rate was 95.5% and 53.8% in the low‐/intermediate‐ and high‐grade cases, respectively. In the high‐grade group, cases with recurrence were found to have a higher rate of lymph nodes metastasis than cases without recurrence. Furthermore, in this high‐grade group, total sacrifice of the facial nerve did not reduce local recurrence. However, radical resection in the cases without tumor invasion to the nerve has decreased the local recurrence rate. The CRTC1‐MAML2 fusion gene was expressed in 42.3% of low‐/intermediate‐ and 14.3% of high‐grade cases. Conclusions The survival rate in MEC was quite different between the low‐/intermediate‐ and high‐grade cases. However, the rate of correct assessment of the grade by fine‐needle aspiration cytology was poor. In high‐grade cases, total sacrifice of the facial nerve may improve the rate of local recurrence in cases without invasion of the main trunk of the nerve. Expression of the CRTC1‐MAML2 fusion gene could be helpful in not only the assessment of grade but the prediction of recurrence. Level of Evidence 4

Histology

10.1002/lio2.809

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Citations (11)