Anna L. Godfrey

Cambridge University Hospitals NHS Foundation Trust

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Co-Authors

Anthony R. Green

University of Cambridge

Claire Harrison

Guy's and St Thomas' NHS Foundation Trust

Jyoti Nangalia

Wellcome Sanger Institute

E. Joanna Baxter

Wellcome/MRC Cambridge Stem Cell Institute

Adam J. Mead

MRC Weatherall Institute of Molecular Medicine

Peter J. Campbell

Wellcome Sanger Institute

Mary Frances McMullin

Belfast City Hospital

Joanne Ewing

Heart of England NHS Foundation Trust

Steven Knapper

Cardiff University

Paola Guglielmelli

University of Florence

Cooperative Institutions

University of Cambridge

164

University College London

107

University of Oxford

Medical Research Council

Cambridge University Hospitals NHS Foundation Trust

National Institute for Health Research

University of Manchester

Addenbrooke's Hospital

Wellcome/MRC Cambridge Stem Cell Institute

Wellcome Sanger Institute

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Distinct Clinical Phenotypes Associated with JAK2V617F Reflect Differential STAT1 Signaling

Cancer Cell (2010)

Edwin Chen Philip Beer Anna L. Godfrey Christina A. Ortmann Juan Li

STAT1

STAT5

Myeloproliferative Disorders

Janus kinase 2

10.1016/j.ccr.2010.10.013

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Citations (164)

A GENOMEWIDE ASSOCIATION STUDY IDENTIFIES NOVEL LOCI THAT PREDISPOSE TO MYELOPROLIFERATIVE NEOPLASMS

Haematologica (2013)

Andrew Jones William Tapper Róbert Královics Katerina Zoi Anna L. Godfrey

Myeloproliferative Disorders

Hematologic Neoplasms

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Results of a national UK physician reported survey of COVID-19 infection in patients with a myeloproliferative neoplasm

Leukemia (2021)

Richard Anthony Salisbury Natalia Curto‐García Jennifer O’Sullivan Frederick Chen Paolo Polzella

Myeloproliferative neoplasm

Neoplasm

2019-20 coronavirus outbreak

Hematology

Hematologic Neoplasms

10.1038/s41375-021-01143-2

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Citations (9)

Changing minds about climate change in Indonesia through a TV drama

Frontiers in Communication (2024)

Donald P. Green Rosiana Eko Lionel Ong Benedek Paskuj Anna L. Godfrey

Drama has been shown to change attitudes and inspire action on topics as diverse as health, sanitation, intergroup conflict, and gender equality, but rarely have randomized trials assessed the influence of narrative entertainment programs focusing on climate change and environmental protection. We report the results of an experiment in which young Indonesian adults were sampled from five metropolitan areas. Participants were randomly assigned to watch a condensed two-hour version of a new award-winning TV drama series #CeritaKita (Our Story) — and accompanying social media discussion program Ngobrolin # CeritaKita (Chatter—Our Story)—as opposed to a placebo drama/discussion that lacked climate and environmental content. Outcomes were assessed via survey 1–7 days after exposure to the shows, and through a follow up survey after 5 months. We find that the treatment group became significantly more knowledgeable about environmental issues such as deforestation, an effect that persists long term. Other outcomes, such as motivation to participate in public discussion on climate change, willingness to follow influencers who post about environmental issues on social media, support for policies to address climate change and support for more media coverage of this issue, moved initially after viewing but subsided over time, possibly due to lack of continued exposure and other changes in context. This pattern of results suggests that ongoing/seasonal programming may be needed in order to sustain attitudinal and behavioral change.

10.3389/fcomm.2024.1366289

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Clonal origin of KMT2A wild-type lineage-switch leukemia following CAR-T cell and blinatumomab therapy

Nature Cancer (2023)

Tim H. H. Coorens Grace Collord Taryn D. Treger Stuart Adams Emily Mitchell

Abstract Children with acute lymphoblastic leukemia (ALL) undergoing anti-CD19 therapy occasionally develop acute myeloid leukemia (AML). The clonal origin of such lineage-switch leukemias 1–4 remains unresolved. Here, we reconstructed the phylogeny of multiple leukemias in a girl who, following multiply relapsed ALL, received anti-CD19 cellular and antibody treatment and subsequently developed AML. Whole genome sequencing unambiguously revealed the AML derived from the initial ALL, with distinct driver mutations that were detectable before emergence. Extensive prior diversification and subsequent clonal selection underpins this fatal lineage switch. Genomic monitoring of primary leukemias and recurrences may predict therapy resistance, especially regarding anti-CD19 treatment.

Lineage (genetic)

Blinatumomab

10.1038/s43018-023-00604-0

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Citations (10)

Deep Purple Payload Qualifies for NASA Launch, Could Provide New Method for Real-Time Space-Domain Awareness

OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (2024)

Jordan Smilo F. Ravizza J Ganino Jordan Karburn Lance M. Simms

Payload (computing)

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