John A. Crump

Duke Medical Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Matthew P. Rubach

Kilimanjaro Christian Medical Centre

Venance P. Maro

Kilimanjaro Christian Medical Centre

Blandina T. Mmbaga

Kilimanjaro Christian Medical Centre

Sarah Cleaveland

University of Glasgow

John Bartlett

Duke Institute for Health Innovation

Michael J. Maze

University of Otago

Jo E. B. Halliday

University of Glasgow

Anne B. Morrissey

Duke University

Simon I Hay

Institute for Health Metrics and Evaluation

Julian T. Hertz

Duke Medical Center

Cooperative Institutions

Institute for Health Metrics and Evaluation

1,481

University of Washington

1,457

Seattle University

422

Harvard University

306

Centers for Disease Control and Prevention

296

Auckland University of Technology

273

University College London

266

Hôpital Xavier Arnozan

259

Johns Hopkins University

248

National Institutes of Health

222

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Two Decades of Disseminated Tuberculosis at a University Medical Center: The Expanding Role of Mycobacterial Blood Culture

Clinical Infectious Diseases (2003)

John A. Crump L. B. Reller

We describe the clinical presentation, predisposing conditions, diagnostic approach, and outcome for 52 patients with disseminated tuberculosis who presented at Duke University Medical Center (Durham, NC) from 1980 through 1999. The mean age of the patients was 52 years (range, 2-93 years). Fever and weight loss were common at presentation, and delays in the initiation of therapy often occurred. Predisposing conditions included human immunodeficiency virus infection (46% of patients), immunosuppressive therapy (21%), alcoholism (12%), diabetes mellitus (12%), and hematologic disorders (8%); 17% of patients had no disorder of immunity detected. Examination of biopsy specimens from sites of localized disease, especially lymph nodes, had a high diagnostic yield. In this study, mycobacterial blood culture appeared to be as sensitive as bone marrow culture in diagnosing disseminated tuberculosis (sensitivity, 58% vs. 54%). To diagnose disseminated tuberculosis, a search for sites of localized disease should be undertaken, and samples from these sites should be obtained. Mycobacterial blood culture can play an increasing role in the diagnosis of disseminated tuberculosis when localized disease is not found.

Blood Culture

Center (category theory)

10.1086/378273

Cite

Citations (80)

2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea

Clinical Infectious Diseases (2017)

Andi L. Shane Rajal K. Mody John A. Crump Phillip I. Tarr Theodore S. Steiner

These guidelines are intended for use by healthcare professionals who care for children and adults with suspected or confirmed infectious diarrhea. They are not intended to replace physician judgement regarding specific patients or clinical or public health situations. This document does not provide detailed recommendations on infection prevention and control aspects related to infectious diarrhea.

Judgement

Clinical judgement

Health Professionals

Pediatric Infectious Disease

10.1093/cid/cix669

Cite

Citations (475)

Open Access Data for Prevalence and distribution of non-typhoidal Salmonella enterica serogroups and serovars isolated from normally sterile sites: a global systematic review

Harvard Dataverse (2023)

Nienke N. Hagedoorn Shruti Murthy Megan Birkhold Christian S. Marchello John A. Crump

This is the open access data for the publication 'Prevalence and distribution of non-typhoidal Salmonella enterica serogroups and serovars isolated from normally sterile sites: a global systematic review' by N.N. Hagedoorn, et al.

Salmonella enterica

10.7910/dvn/ayfrx1

Cite

Citations (0)

Nosocomial transmission of tuberculosis in Africa documented by restriction fragment length polymorphism

Transactions of the Royal Society of Tropical Medicine and Hygiene (1997)

David Wilkinson John A. Crump Manormoney Pillay A. Willem Sturm

Journal Article Nosocomial transmission of tuberculosis in Africa documented by restriction fragment length polymorphism Get access David Wilkinson, David Wilkinson ∗ 1Centre for Epidemiological Research in Southern Africa, South African Medical Research Council, P.O. Box 658, Hlabisa, 3937, South Africa2Hlabisa Hospital, Hlabisa 3937, South Africa ∗Author for correspondence. Search for other works by this author on: Oxford Academic PubMed Google Scholar John Crump, John Crump 1Centre for Epidemiological Research in Southern Africa, South African Medical Research Council, P.O. Box 658, Hlabisa, 3937, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar Manormoney Pillay, Manormoney Pillay 3Department of Medical Microbiology, University of Natal, Durban, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar A.Willem Sturm A.Willem Sturm 3Department of Medical Microbiology, University of Natal, Durban, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 91, Issue 3, May-June 1997, Page 318, https://doi.org/10.1016/S0035-9203(97)90090-0 Published: 01 June 1997 Article history Received: 08 October 1996 Revision received: 26 November 1996 Accepted: 27 November 1996 Published: 01 June 1997

Fragment (logic)

10.1016/s0035-9203(97)90090-0

Cite

Citations (27)

Global Burden of Invasive NontyphoidalSalmonellaDisease, 20101

Emerging infectious diseases (2015)

Trong Ao Nicholas Feasey Melita A. Gordon Karen H. Keddy Frederick J. Angulo

Nontyphoidal Salmonella is a major cause of bloodstream infections worldwide, and HIV-infected persons and malaria-infected children are at increased risk for the disease. We conducted a systematic literature review to obtain age group-specific, population-based invasive nontyphoidal Salmonella (iNTS) incidence data. Data were categorized by HIV and malaria prevalence and then extrapolated by using 2010 population data. The case-fatality ratio (CFR) was determined by expert opinion consensus. We estimated that 3.4 (range 2.1-6.5) million cases of iNTS disease occur annually (overall incidence 49 cases [range 30-94] per 100,000 population). Africa, where infants, young children, and young adults are most affected, has the highest incidence (227 cases [range 152-341] per 100,000 population) and number of cases (1.9 [range 1.3-2.9] million cases). An iNTS CFR of 20% yielded 681,316 (range 415,164-1,301,520) deaths annually. iNTS disease is a major cause of illness and death globally, particularly in Africa. Improved understanding of the epidemiology of iNTS is needed.

10.3201/eid2106.140999

Cite

Citations (423)

Missed opportunities for diagnosis of tuberculosis and human immunodeficiency virus co-infection in Moshi, Tanzania.

PubMed (2009)

Alison C. Tribble Carol Hamilton John A. Crump Anna Mgonja Antipas Mtalo

A community-based voluntary counseling and testing (VCT) center in Moshi, Tanzania.

AIDS-Related Opportunistic Infections

Source

Cite

Citations (9)

Mapping the Incidence Rate of Typhoid Fever in Sub-Saharan Africa

Jong‐Hoon Kim Jungsoon Choi Chaelin Kim Gi Deok Pak Prerana Parajulee

Background: With more than 1.2 million illnesses and 29,000 deaths in sub-Saharan Africa in 2017, typhoid fever continues to be a major public health problem. Effective control of the disease would benefit from an understanding of the subnational geospatial distribution of the disease incidence.Method: We collated records of the incidence rate of typhoid fever confirmed by culture of blood in Africa from 2000 to 2022. We estimated the typhoid incidence rate for sub-Saharan Africa on 20 km × 20 km grids by exploring the association with geospatial covariates representing access to improved water and sanitation, health conditions of the population, and environmental conditions.Results: We identified six published articles and one pre-print representing incidence rate estimates in 22 sites in 2000-2022. Estimated incidence rates showed geospatial variation at sub-national, national, and regional levels. The incidence rate was high in Western and Eastern African subregions followed by Southern and Middle African subregions. By age, the incidence rate was highest among 5-14 yo followed by 2-4 yo, > 14 yo, and 0-1 yo. When aggregated across all age classes and grids that comprise each country, predicted incidence rates ranged from 43.7 (95% confidence interval: 0.6 to 591.2) in Zimbabwe to 2,957.8 (95% CI: 20.8 to 4,245.2) in South Sudan per 100,000 person-years. Sub-national heterogeneity was evident with the coefficient of variation at the 20 km × 20 km grid-level ranging from 0.7 to 3.3, and was generally lower in high-incidence countries and widely varying in low-incidence countries.Conclusion: Our study provides estimates of 20 km × 20 km incidence rate of typhoid fever across sub-Saharan Africa based on data collected from 2000 through 2020. Increased understanding of the subnational geospatial variation of typhoid fever in Africa may inform more effective intervention programs by better targeting resources to heterogeneously disturbed disease risk.Funding: This work was supported, in whole or in part, by Gavi, the Vaccine Alliance, and the Bill & Melinda Gates Foundation, via the Vaccine Impact Modelling Consortium (Grant Number OPP1157270 / INV-009125) and the Severe Typhoid Fever in Africa Program (Grant Number OPP1127988).Declaration of Interest: The authors declare that they have no competing interests.

10.2139/ssrn.4420784

Cite

Citations (0)

GUIDELINES FOR INTERNATIONAL SERVICE LEARNING PROGRAMS

Developing World Bioethics (2011)

John A. Crump Jeremy Sugarman

10.1111/j.1471-8847.2011.00315.x

Cite

Citations (1)

Mapping fever aetiologies in malaria-endemic areas: an interactive, open-access, on-line map

Tropical Medicine & International Health (2015)

Heidi Hopkins N V Thomas John A. Crump Ismael González Philippe J. Guérin

Endemic diseases

Source

Cite

Citations (0)

TaqMan Array Card real‐time polymerase chain reaction panel to detect pathogens in whole blood of febrile inpatients in northern Tanzania, 2016–2019

Tropical Medicine & International Health (2024)

James S. Ngocho Jie Liu Nathaniel H. Kalengo Asia Hemed Kipengele Athanasia Maro

Acute febrile illness is a common reason for seeking healthcare in low- and middle-income countries. We describe the diagnostic utility of a TaqMan Array Card (TAC) real-time polymerase chain reaction (PCR) panel for pathogen detection in paediatric and adult inpatients admitted with febrile illness.

TaqMan

10.1111/tmi.14083

Cite

Citations (0)