The Depolymerization of Thymonucleic Acid by an Enzyme System in Normal and Cancerous Hepatic and Mammary Tissues and in the Milk and Sera of Several Species Get access Jesse P. Greenstein, Jesse P. Greenstein research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Wendell V. Jenrette Wendell V. Jenrette junior physiologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 1, Issue 6, June 1941, Pages 845–863, https://doi.org/10.1093/jnci/1.6.845 Published: 01 June 1941
We have shown1 that the liver catalase activity of rats carrying the subcutaneously implanted hepatic tumor No. 31* was about one-tenth that of the livers of normal rats.In order to determine whether this lowering of liver catalase activity was directly clue to the presence of the transplanted tumor, the latter was completely excised from a number of animals under ether anesthesia.About half the number of these animals was sacrificed at intervals and the liver catalase activity determined.The remainder of the animals, 48 hours after operation, were reinoculated subcutaneously with fresh tumor material, and the second tumor allowed to grow for 4 weeks.The liver catalase at this point was determined on a few animals, and from the remainder the tumors were again excised.The latter animals were sacrificed at intervals following this second operation and the liver catalase activity determined.The data are given in the accompanying table.The method of determining the cat.alase activity has been described.lIncluded in the table are data on regenerating rat livers.The data reveal (a) that the lowered liver catalase activity of tumor-bearing rats is attributable to the presence of the tumor, (b) that this effect is apparently reversible, and (c) t,hat liver regenerating in animals carrying the tumor behaves like nonregenerating liver under the same circumstances.Further experiments have shown that fasting has no apparent effect on the liver catalase activity of either normal or tumorbearing rats.
Ribonuclease and Thymonucleodepolymerase Get access Jesse P. Greenstein, Jesse P. Greenstein research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Wendell V. Jenrette Wendell V. Jenrette junior physiologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 2, Issue 3, December 1941, Pages 301–303, https://doi.org/10.1093/jnci/2.3.301 Published: 01 December 1941
Effects of Ultraviolet Radiation on Sodium Thymonucleate Get access Alexander Hollaender, Alexander Hollaender senior biophysicist Division of Industrial Hygiene Search for other works by this author on: Oxford Academic PubMed Google Scholar Jesse P. Greenstein, Jesse P. Greenstein research fellow Search for other works by this author on: Oxford Academic PubMed Google Scholar Wendell V. Jenrette Wendell V. Jenrette junior physiologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 2, Issue 1, August 1941, Pages 23–28, https://doi.org/10.1093/jnci/2.1.23 Published: 01 August 1941
The extensive and ingenious studies of Caspersson (Caspersson, 1936; Caspersson, Hammarsten and Hammarsten, 1935) have revealed the nucleic acid-protein distribution in the chromosomes during certain phases of cell development. The intramolecular structure of both ribose- and desoxyribose nucleic acids has received attention from a host of workers, notably Levene (Levene and Bass, 1931), Thannhauser (Thannhauser and Angermann, 1929), Feulgen (1890), and Bredereck (Bredereck and Muller, 1939). In contrast to the considerable literature from organic chemical and biological sources, the reported studies on the physical chemistry of the nucleic acids have been very meager. Hammarsten (1924) described certain of the physical properties of thymonucleic acid, and later in a brief note with Signer, Caspersson and Hammarsten (1938) made the observation that sodium thymonucleate was highly polymerized and showed intense double refraction of flow in aqueous solution.
Journal Article Chemical Studies on the Components of Normal and Neoplastic Tissues. I. Viscosity and Streaming Birefringence of Sodium Thymonucleate Get access Jesse P. Greenstein, Jesse P. Greenstein research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Wendell V. Jenrette Wendell V. Jenrette technical assistance National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 1, Issue 1, 1940-1941, Pages 77–90, https://doi.org/10.1093/jnci/1.1.77 Published: 01 August 1940
Journal Article Chemical Studies on the Components of Normal and Neoplastic Tissues. II. The Nucleoprotein Fraction of Normal Animal Liver Get access Jesse P. Greenstein, Jesse P. Greenstein research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Wendell V. Jenrette Wendell V. Jenrette technical assistance National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 1, Issue 1, 1940-1941, Pages 91–104, https://doi.org/10.1093/jnci/1.1.91 Published: 01 August 1940
'/%3e%3cuse xlink:href='%23a' transform='translate(0 -400)'/%3e%3cuse xlink:href='%23a' transform='translate(0 -600)'/%3e%3cuse xlink:href='%23a' transform='translate(0 -800)'/%3e%3cuse xlink:href='%23a' transform='translate(0 -1000)'/%3e%3cuse xlink:href='%23a' transform='translate(0 -1200)'/%3e%3cpath d='M0 0h1400v800H0z' style='fill:%23010066'/%3e%3cpath d='M576 100c-166.146 0-301 134.406-301 300s134.854 300 301 300c60.027 0 115.955-17.564 162.927-47.783-27.353 9.44-56.71 14.602-87.271 14.602-147.327 0-266.897-119.172-266.897-266.01 0-146.837 119.57-266.01 266.897-266.01 32.558 0 63.746 5.815 92.602 16.468C696.217 118.91 638.305 100 576 100z' style='fill:%23fc0'/%3e%3cpath d='m914.286 471.429-99.538-53.25 29.43 108.982-66.575-91.165-20.77 110.96-20.428-111.024-66.857 90.96L699.314 418l-99.701 52.943 74.065-85.192-112.8 4.441 103.694-44.62-103.555-44.94L673.8 305.42 600 220l99.538 53.25-29.43-108.982 66.575 91.165 20.77-110.96 20.428 111.023 66.857-90.959L814.97 273.43l99.702-52.944-74.065 85.193 112.8-4.441-103.694 44.62 103.555 44.94-112.785-4.79z' style='fill:%23fc0' transform='matrix(1.2738 0 0 1.2423 -89.443 -29.478)'/%3e%3c/svg%3e)
'%3e%3cpath fill='%23012169' d='M0 0v30h60V0z'/%3e%3cpath stroke='%23fff' stroke-width='6' d='m0 0 60 30m0-30L0 30'/%3e%3cpath stroke='%23C8102E' stroke-width='4' d='m0 0 60 30m0-30L0 30' clip-path='url(%23b)'/%3e%3cpath stroke='%23fff' stroke-width='10' d='M30 0v30M0 15h60'/%3e%3cpath stroke='%23C8102E' stroke-width='6' d='M30 0v30M0 15h60'/%3e%3c/g%3e%3c/svg%3e)