An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
To compare the outcomes in hematological patients receiving unrelated peripheral blood stem cell transplants (UPBSCT) with those receiving unrelated bone marrow transplants (UBMT) in a retrospective analysis.Sixty-three patients with hematological diseases with HLA-matched (65%) or mismatched (35%) unrelated donors were receiving UPBSCT (n = 33) or UBMT (n = 30) between May 2001 and June 2005 in our institute. They all received standard conditioning regimens with Bu/Cy (n = 53) or TBI/Cy (n = 10) with the addition of ATG for 3 - 4 days (n = 58) or CD3 antibody (n = 5). There were more patients receiving rabbit ATG in the UPBSCT group than UBMT (21/33 vs 8/25, P = 0.02) and the remaining patients received pig ATG. Graft versus host disease (GVHD) prophylaxis consisting of cyclosporine, methotrexate and mycophenolate mofetil were the same.The two groups were matched for the following factors: gender, diagnosis, HLA-compatibility and conditioning regimens. The median age in the UPBSCT group was 29.5 (10 - 47) years and in the UBMT 21.5 (7 - 42) years (P < 0.05). The UPBSCT group consisted of 10 females and 23 males and the UBMT group 7 females and 23 males. Eleven patients in the UPBSCT and 8 patients in the UBMT group were diagnosed with as chronic myeloid leukemia (CML); 9 and 12 as acute myelocytic leukemia (AML); 11 and 10 as acute lymphatic leukemia (ALL); 2 and 0 as severe aplastic anemia (SAA). There were more patients in aggressive stage (>CR1) in the UBMT group than in the UPBSCT group (9/30 vs 3/33, P = 0.06). Median follow-up was 12 months after UPBSCT and 20 months after UBMT (P < 0.05). UPBSCT group had a higher number of infused MNC as comparison with UBMT group (6.16 x 10(8)/kg vs 2.80 x 10(8)/kg, P < 0.05). Both neutrophil and platelet recovery were faster after UPBSCT (11 days vs 17 days, 14 days vs 27.5 days, P < 0.01). Although the cumulative incidence of grades II - IV acute GVHD and severe aGVHD in the UPBSCT group were less than in the UBMT group (33.04% vs 66.69%, 7.26% vs 34.52%, P < 0.05), there was no difference after the source of ATG was counted. The incidence of chronic GVHD did not differ between the two groups (18/25 vs 14/22). Relapse including molecular relapse occurred in 6 of the 31 patients after UPBSCT and in 4 of the 30 patients after UBMT (P > 0.05). Finally, fifteen of the 30 patients died after UBMT, as compared with 8 of the 33 patients after UPBSCT. The cumulative overall survival was 62.45% after UPBSCT and 47.22% after UBMT (P = 0.114).Our results indicate that UPBSCT led to significantly faster leukocyte and platelet engraftment without increasing the incidence of aGVHD and the overall survival was comparable between the two methods of therapy.
The functionalization of polyoxovanadate clusters is promising but of great challenge due to the versatile coordination geometry and oxidation state of vanadium. Here, two unprecedented silsesquioxane ligand-protected "fully reduced" polyoxovanadate clusters were fabricated via a facial solvothermal methodology. The initial mixture of the two polyoxovanadate clusters with different colors and morphologies (green plate V14 and blue block V6) was successfully separated as pure phases by meticulously controlling the assembly conditions. Therein, the V14 cluster is the highest-nuclearity V-silsesquioxane cluster to date. Moreover, the transformation from a dimeric silsesquioxane ligand-protected V14 cluster to a cyclic hexameric silsesquioxane ligand-protected V6 cluster was also achieved, and the possible mechanism termed "ligand-condensation-involved dissociation reassembly" was proposed to explain this intricate conversion process. In addition, the robust V6 cluster was served as a heterogeneous catalyst for the synthesis of important heterocyclic compounds, quinazolinones, starting from 2-aminobenzamide and aldehydes. The V6 cluster exhibits high activity and selectivity to access pure quinazolinones under mild conditions, where the high selectivity was attributed to the confinement effect of the macrocyclic silsesquioxane ligand constraining the molecular freedom of the reaction species. The stability and recyclability as well as the tolerance of a wide scope of aldehyde substrates endow the V6 cluster with a superior performance and appreciable potential in catalytic applications.
Focusing on signed digraph(SDG)models holding inaccurate information to induce spurious solution,causal ordering analysis is introduced to resolve causal dependent relation of system variables.The hierarchical causal dependent relation among variables in system equations is revealed by complete subsets iteration of self-contained structure of equilibrium structure and integral chain reduction in canonical form of dynamic structure.The causal dependent effect among variables is obtained by coefficients identification.SDG models are then constructed for linear systems of three forms of equilibrium structure,dynamic structure and mixed structure based on causal ordering analysis.The experimental instance indicates that in the SDG model constructed the spurious information is removed and the accuracy of SDG model is improved effectively.
The available satellites in Global Navigation Satellite System (GNSS) are much more than single positioning system. The satellite selection algorithm is needed to reduce the computation of hardware in GNSS receiver. The positioning accuracy is proportional to the geometric dilution of precision (GDOP) which is determined by the positions of available satellites and receiver in the single positioning system. However, GDOP is not the only factor affect positioning accuracy in the multi-system because of the different pseudorange measurement accuracy (UERE) of each system. The items of GDOP were introduced in this paper at first. Then, the relationship between the positioning error and UERE was analyzed amply. And a satellite selection algorithm for GNSS multi-system based on UERE was proposed in this paper at last. The GDOP was weighted by UEREs of each system and selected the satellite according to the new weighted GDOP. The simulation results showed the effectiveness of the algorithm.
In this study, Ni40Co18Cr18Fe14Al5Ti5 high-entropy alloys (HEAs) with a near-equiaxed grain structure and cellular substructures, devoid of significant microstructural imperfections, was produced via selective laser melting (SLM). The absence of brittle precipitates or substantial processing defects, which typically serving as fracture-weakening origins, allowed for effective activation of dislocation motion, deformation twinning, and stacking faults ahead of the crack tip. These mechanisms contributed to exceptional impact toughness (∼1600 kJ/m2) and dynamic crack initiation toughness (∼1000 kJ/m2). With an impressive yield strength (∼810 MPa), our SLM-produced HEA demonstrates a unique combination of impact toughness and strength that surpasses current additively manufactured metals.
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