David L. Wheaton

Oregon Health & Science University

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P. Barton Duell

Oregon Health & Science University

Kenneth A. Burry

Oregon Health & Science University

Harold G. Spies

Oregon National Primate Research Center

Phillip E. Patton

Oregon Health & Science University

Lewis Wesselius

Mayo Clinic in Arizona

Karen A. McKinney

Queen's University Belfast

Fredrick N. Hanson

University of Kansas

D. Roger Illingworth

Oregon Health & Science University

Hien Minh Nguyen

Hanoi National University of Education

W E Connor

Oregon Health & Science University

Cooperative Institutions

Oregon Health & Science University

University of Kansas Medical Center

Oregon National Primate Research Center

Oregon Medical Research Center

Albert Einstein College of Medicine

Jacobi Medical Center

University of Kansas

United States Department of Veterans Affairs

St George's, University of London

University of Southern California

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Differential effects of subcutaneous on low-density lipoprotein size and in postmenopausal rhesus monkeys estrogen and progesterone susceptibility to oxidation

Karen A. McKinney P. Barton Duell David L. Wheaton David L. Hess Phillip E. Patton

Objective: To study the differential effects of subcutaneous E, alone or in combination with P on the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation in naturally postmenopausal diet-controlled rhesus monkeys. Design: Prospective, longitudinal controlled study. Setting: Oregon Health Sciences University, Portland, Oregon, and Oregon Regional Primate Research Center, Beaver-ton, Oregon. Patient(s): Five naturally postmenopausal rhesus monkeys. Intervention(s): Estradiol was administered subcutaneously for the first 4 weeks, followed by Ez plus P for 4 weeks, followed by a third 4-week washout period. Main Outcome Measure(s): Changes in plasma lipoprotein levels and oxidation of LDL and serum concentrations of Ez and P. Result(s): Levels of LDL cholesterol fell after 4 weeks of treatment with Ez, compared with baseline. The lag time to half maximal light absorbancy after 4 weeks of Ez treatment was significantly increased compared with baseline. The maximal absorbance values and the slope of the propagation phase after 4 weeks of treatment with Ez were decreased compared with baseline. After 4 weeks of combined Ez and P treatment, all values were comparable to baseline. Conclusion(s): These results suggest that subcutaneous Ez therapy appears to enhance LDL resistance to oxidation and that this effect is attenuated by the addition of the P. (Fertil Sterile 1997;68:525-30.

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Low-density lipoprotein

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Differential effects of subcutaneous estrogen and progesterone on low-density lipoprotein size and susceptibility to oxidation in postmenopausal rhesus monkeys

Fertility and Sterility (1997)

Karen A. McKinney P. Barton Duell David L. Wheaton Rex A. Hess Phillip E. Patton

Washout

Differential effects

Low-density lipoprotein

Subcutaneous injection

10.1016/s0015-0282(97)00237-9

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Citations (12)

Diet-induced, functional low density lipoprotein receptor deficiency in a healthy young man

Journal of Investigative Medicine (1996)

P. Barton Duell David L. Wheaton D. Roger Illingworth W E Connor

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Inhibition of LDL oxidation by melatonin requires supraphysiologic concentrations

Clinical Chemistry (1998)

P. Barton Duell David L. Wheaton Amy Shultz Hien Minh Nguyen

Melatonin has been suggested as a potent antioxidant that may protect against development of atherosclerosis and cancer; however, these effects are unproven and controversial. The antioxidant capacity of melatonin was tested in comparison with alpha-tocopherol, ascorbic acid, and the melatonin precursors tryptophan and serotonin, by measuring inhibition of metal ion-mediated and human macrophage-mediated oxidation of LDL. Melatonin had weak antioxidant activity that was detectable only at concentrations 10000- to 100000-fold higher than physiologic concentrations. These results were comparable with published data showing that the radical scavenging activity of melatonin requires markedly supraphysiologic concentrations. In contrast, alpha-tocopherol was 50- to 100-fold more potent and was efficacious at physiologic concentrations. Ascorbic acid and tryptophan also were active at physiologic concentrations and were significantly more potent than melatonin. In summary, extremely supraphysiologic concentrations of melatonin had only weak antioxidant activity, which was surpassed by alpha-tocopherol, ascorbic acid, and tryptophan.

10.1093/clinchem/44.9.1931

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Citations (49)

Lymphocyte Subsets in Lung Cancer

CHEST Journal (1987)

Lewis Wesselius David L. Wheaton Lois J. Manahan-Wahl Sarah L. Sherard Sarah A. Taylor

Hypoalbuminemia

10.1378/chest.91.5.725

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Citations (35)

Airway Secretory IgA Concentrations in Patients with Lung Cancer

CHEST Journal (1989)

Lewis Wesselius Diana S. Dark Fredrick N. Hanson David L. Wheaton

Immunoglobulin A

10.1378/chest.95.6.1265

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A mimicking red blood cell autoantibody accompanying transfusion and alloimmunization

Transfusion (1982)

Barry Wenz Karl F. Gurtlinger David L. Wheaton E. P. Dugan

A patient with sickle cell disease who concomitantly developed red cell autoimmunity and alloimmunization is reported. The implied but 'wrong' specificity of the autoantibody mimicked one of the alloantibodies in the patient's serum. Although the patient's red blood cells phenotyped at Ro4, anti-rh" was eluted from them on several occasions. Absorption and secondary elution from selected cells proved the cell bound antibody had a unique and independent specificity from the anti-rh" in his serum. Standard antibody identification procedures did not distinguish these differences.

Red Cell

Isoantibodies

10.1046/j.1537-2995.1982.22282177123.x

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Citations (17)