Brandon S. Gettleman

University of Southern California

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Nathanael D. Heckmann

University of Southern California

Alexander B. Christ

University of California, Los Angeles

Lawrence R. Menendez

Keck Hospital of USC

Andy Ton

University of Southern California

Mary K. Richardson

University of Southern California

Kevin C. Liu

Keck Hospital of USC

Jennifer C. Wang

Keck Hospital of USC

Mina Ayad

University of Southern California

Jeffrey C. Wang

University of Southern California

Amit S. Piple

Keck Hospital of USC

Cooperative Institutions

University of Southern California

Keck Hospital of USC

University of California, Los Angeles

Heckmann (Germany)

Intellijoint Surgical (Canada)

Smith & Nephew (Switzerland)

Orthopaedic Hospital

Musculoskeletal Tumor Society

Southern California University for Professional Studies

Neurological Surgery

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Functional outcomes of oncologic reverse total shoulder arthroplasty after tumor resection

Seminars in Arthroplasty JSES (2023)

Caroline E. Vonck Hyunwoo P. Kang Jennifer A. Bell Brandon S. Gettleman Rohan Sebastian

10.1053/j.sart.2022.12.006

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Citations (2)

Post-Operative Complications Associated with Long-Term NSAID or Long-Term Opioid Use Prior to Lumbar Spinal Fusion Surgery

Clinical Neurology and Neurosurgery (2023)

Alexander M. Ballatori Shane Shahrestani Andy Ton Xiao T. Chen Brandon S. Gettleman

Veterans Affairs

Odds

10.1016/j.clineuro.2023.108093

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Citations (0)

Systematic Review and Meta-Analysis of Intrawound Vancomycin in Total Hip and Total Knee Arthroplasty: A Continued Call for a Prospective Randomized Trial

The Journal of Arthroplasty (2022)

Kamran Movassaghi Jennifer C. Wang Brandon S. Gettleman Cory K. Mayfield Daniel A. Oakes

10.1016/j.arth.2022.03.047

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Citations (29)

Intravenous tranexamic acid reduces complications following surgical treatment of pathologic fractures of the lower extremity

Journal of Surgical Oncology (2024)

Brandon S. Gettleman Kevin C. Liu Mary K. Richardson Matthew Chen Arad Talehakimi

Abstract Background and Objectives This study aimed to evaluate the postoperative complications associated with administering intravenous (IV) tranexamic acid (TXA) in patients undergoing surgical fixation for neoplastic pathologic fractures of the lower extremities. Methods Patients ≥18 years old who underwent surgical intervention for neoplastic pathologic lower extremity fractures from 2015 to 2021 were identified using the Premier Healthcare Database. This cohort was divided by TXA receipt on the index surgery day. Patient demographics, hospital factors, patient comorbidities, and 90‐day complications were assessed and compared between the cohorts. Results From 2015 to 2021, 4497 patients met inclusion criteria (769 TXA[+] and 3728 TXA[−]). Following propensity score matching, patients who received TXA had a significantly shorter length of stay than those who did not (7.6 ± 7.3 days vs. 9.0 ± 15.2, p = 0.036). Between the two cohorts, there were no significant differences in comorbidities. Regarding differences in postoperative complications, TXA(+) patients had significantly decreased odds of deep vein thrombosis (DVT) (1.87% vs. 5.46%; odds ratio [OR]:0.33; 95% confidence interval: 0.17–0.62; p = 0.001). Conclusion Administration of IV TXA may be associated with a decreased risk of postoperative DVT without an increased risk of other complications. Orthopedic surgeons should consider the utilization of IV TXA in patients treated surgically for neoplastic pathologic fractures of the lower extremity.

10.1002/jso.27601

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A “1.5-Stage” Spacer Construct Using Revision Components for the Management of Periprosthetic Joint Infection of the Knee

The Journal of Arthroplasty (2025)

Nathanael D. Heckmann Brett M. Biedermann Mary K. Richardson Matthew Chen Brandon S. Gettleman

Joint infections

10.1016/j.arth.2025.01.044

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Systematic Review and Meta-Analysis of the Effect of Osteoporosis on Fusion Rates and Complications Following Surgery for Degenerative Cervical Spine Pathology

The International Journal of Spine Surgery (2024)

Elizabeth Lechtholz‐Zey Mina Ayad Brandon S. Gettleman Emily S. Mills Hannah Shelby

Background

As the elderly population grows, the increasing prevalence of osteoporosis presents a unique challenge for surgeons. Decreased bone strength and quality are associated with hardware failure and impaired bone healing, which may increase the rate of revision surgery and the development of complications. The purpose of this review is to determine the impact of osteoporosis on postoperative outcomes for patients with cervical degenerative disease or deformity.

Methods

A systematic review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and Medical Subject Headings terms involving spine surgery for cervical degenerative disease and osteoporosis were performed. This review focused on radiographic outcomes, as well as surgical and medical complications.

Results

There were 16 studies included in the degenerative group and 9 in the deformity group. Across degenerative studies, lower bone mineral density was associated with increased rates of cage subsidence in osteoporotic patients undergoing operative treatment for cervical degenerative disease. Most studies reported varied results on the relationship between osteoporosis and other outcomes such as revision and readmission rates, costs, and perioperative complications. Our meta-analysis suggests that osteoporotic patients carry a greater risk of reduced fusion rates at 6 months and 1 year postoperatively. With respect to cervical deformity correction, although individual complication rates were unchanged with osteoporosis, the collective risk of incurring any complication may be increased in patients with poor bone stock.

Conclusions

Overall, the literature suggests that outcomes for osteoporotic patients after cervical spine surgery are multifactorial. Osteoporosis seems to be a significant risk factor for developing cage subsidence and pseudarthrosis postoperatively, whereas reports on medical and hospital-related metrics were inconclusive. Our findings highlight the challenges of caring for osteoporotic patients and underline the need for adequately powered studies to understand how osteoporosis changes the risk index of patients undergoing cervical spine surgery.

Clinical Relevance

In patients undergoing cervical spine surgery for degenerative disease, osteoporosis is a significant risk factor for long-term postoperative complications—notably cage subsidence and pseudarthrosis. Given the elective nature of these procedures, interdisciplinary collaboration between providers should be routinely implemented to enable medical optimization of patients prior to cervical spine surgery.

Level of Evidence

10.14444/8568

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Citations (4)

JoVE Video Dataset

Benjamin V. Kelley Stephen D. Zoller Danielle Greig Kellyn R. Hori Nicolas Cevallos

An erratum was issued for: In vivo Mouse Model of Spinal Implant Infection. The Authors section was updated from:

10.3791/6557-v

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Complications of cryoprobe cryoablation as a surgical adjuvant for the treatment of metastatic carcinoma to bone, benign bone tumors, and soft tissue tumors: A series of 148 patients

Journal of Surgical Oncology (2023)

Brandon S. Gettleman Mary K. Richardson Mina Ayad Alexander B. Christ Lawrence R. Menendez

South carolina

10.1002/jso.27500

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Complications of cryoprobe cryoablation as a surgical adjuvant for the treatment of metastatic carcinoma to bone, benign bone tumors, and soft tissue tumors: A series of 148 patients

Journal of Surgical Oncology (2023)

Brandon S. Gettleman Mary K. Richardson Mina Ayad Alexander B. Christ Lawrence R. Menendez

This study describes the complication profile of modern cryoablation utilizing probes as an adjuvant during open surgical treatment of orthopedic tumors.A retrospective, single-surgeon study was performed for patients receiving cryoprobe cryoablation. Demographic information, malignancy-related and operative details, and clinical courses were collected. Outcomes assessed included rates of complications, recurrence, and correlations between the number of probes or cryoablation cycles performed.In this 148-patient study, 67.6% had metastatic carcinoma to bone, 27.7% had benign bone tumors, and 4.7% had soft tissue tumors. An average of 3.4 ± 1.7 cryoablation probes were utilized and 1.7 ± 0.6 freezing cycles were performed. The overall cohort aggregate complication rate was 16.9%. These complications included postoperative fracture (3.4%), nerve palsy (2.7%), wound complications (7.4%), and infection (3.4%). The number of cycles and probes was significantly correlated with the incidence of aggregate complications in the overall cohort (Pearson = 0.162, p = 0.049) and metastatic bone cohort (Pearson = 0.222, p = 0.027). There were 13 recurrences.This study describes the complication rates involving cryoablation probes used as surgical adjuvants. Greater probe number usage was correlated with increased aggregate complications in patients with metastatic disease to bone; meanwhile, more treatment cycles were associated with increased aggregate complications in the overall cohort.

Cryoablation

10.1002/jso.27402

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Citations (1)

The Effect of Osteoporosis on Complications and Reoperation Rates After Surgical Management of Adult Thoracolumbar Spinal Deformity: A Systematic Review and Meta Analysis

Global Spine Journal (2024)

Elizabeth Lechtholz‐Zey Brandon S. Gettleman Mina Ayad Emily S. Mills Hannah Shelby

Systematic Review.

Spinal Deformity

Spinal Surgery

10.1177/21925682241250031

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Citations (5)