Jiangnan Hu

Tianjin University of Science and Technology

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Jianjing Yang

Qufu Normal University

Qichuan Zhuge

First Affiliated Hospital of Wenzhou Medical University

Rui Yang

Tianjin University of Science and Technology

Saidan Ding

First Affiliated Hospital of Wenzhou Medical University

Electron Kebebew

Stanford Medicine

Chandrayee Ghosh

Stanford University

Brian Wang

Rutgers Sexual and Reproductive Health and Rights

Kunlin Jin

University of North Texas

Changhong Ren

Capital Medical University

Anthony Oppong‐Gyebi

University of North Texas

Cooperative Institutions

Wenzhou Medical University

First Affiliated Hospital of Wenzhou Medical University

Tianjin University of Science and Technology

Chinese Academy of Sciences

University of North Texas

University of North Texas Health Science Center

Nanchang University

Fudan University

Sun Yat-sen University

Shanghai Jiao Tong University

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Prospects of Directly Reprogrammed Adult Human Neurons for Neurodegenerative Disease Modeling and Drug Discovery: iN vs. iPSCs Models

Frontiers in Neuroscience (2020)

Ying Zhang Xinyang Xie Jiangnan Hu Kazi Sabrina Afreen Chun‐Li Zhang

A reliable disease model is critical to study specific disease mechanism as well as for discovery and development of new drugs. Despite providing crucial insights into mechanisms of neurodegenerative diseases, translation of this information to develop therapeutics in clinical trials have been unsuccessful. Reprogramming technology to convert adult somatic cells to induced Pluripotent Stem Cells (iPSCs) or directly reprogramming adult somatic cells to induced Neurons (iN), has allowed for creation of better models to understand the molecular mechanisms and design of new drugs. In recent times, the iPSC technology has been commonly used for modeling of neurodegenerative diseases and drug discovery. However, several technological challenges have limited application of iN. As evidences suggest, iN for modeling of neurodegenerative disorders is advantageous compared to those derived from iPSCs. In this review, we will compare iPSCs and iN models for neurodegenerative diseases and their potential applications in future.

Reprogramming

Drug Development

10.3389/fnins.2020.546484

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Citations (15)

Characterization of the key active aroma compounds in Pu-erh tea using gas chromatography–time of flight/mass spectrometry–olfactometry combined with five different evaluation methods

European Food Research and Technology (2021)

Lijuan Ma Manman Gao Jiangnan Hu Wenzhe Tong Liping Du

Olfactometry

10.1007/s00217-021-03847-2

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Citations (16)

マウス脳虚血モデルにおける低酸素ポストコンディショニング促進解糖【JST・京大機械翻訳】

Brain Research (2020)

Changhong Ren Rongrong Han Jiangnan Hu Haiyan Li Li Sijie

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Elevated Blood Urea Nitrogen is associated with Recurrence of post-operative Chronic Subdural Hematoma

Research Square (Research Square) (2020)

Ning Wang Jiangnan Hu Anthony Oppong‐Gyebi Xuanhao Zhu Yihao Li

Abstract Background : Chronic subdural hematoma (CSDH) is fundamentally treatable with about a 2-31% recurrence rate. Recently, there has been renewed interest in the association between Blood Urea Nitrogen (BUN) and intracranial lesion. Therefore, this paper attempts to show the relationship between BUN and CSDH recurrence. Methods: A total of 653 CSDH cases with Burr-hole Irrigation (BHI) were enrolled from December 2014 to April 2019. The analyzed parameters included age, gender, comorbidities, laboratory investigations, medication use and hematoma location. The cases were divided into recurrence and non-recurrence groups while postoperative BUN concentration was further separated into quartiles (Q1 ≤ 4.0 mmol/L, 4.0 < Q2 ≤ 4.9 mmol/L, 4.9 < Q3 ≤ 6.4 mmol/L, Q4 > 6.4 mmol/L). Restricted cubic spline regressions and logistic regression models were performed to estimate the effect of BUN on CSDH recurrence. Results: CSDH recurrence was observed in 96 (14.7%) cases. Significant distinctions were found between recurrence and non-recurrence groups in postoperative BUN quartiles of cases ( P =0.003). After adjusting for the potential confounders, the odds ratio of recurrence was 3.069 (95%CI =1.488–6.330, p = 0.002) for the highest quartile of BUN compared with the lowest quartile. In multiple-adjusted spline regression, a high BUN level visually showed a significantly high OR value of recurrence risk. Conclusions: Elevated BUN at post-operation is significantly associated with the recurrence of CSDH, and it is indicated that high levels of serum BUN after evacuation may serve as a risk factor for CSDH recurrence.

Quartile

Blood urea nitrogen

10.21203/rs.3.rs-17614/v3

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Case report: A rare occurrence of triple malignancy of the stomach, rectum and liver in a single patient

Frontiers in Oncology (2022)

Cancan Jin Jiangnan Hu Kirthikaa Balapattabi Brian Wang Sizhe Hu

Malignant tumors of the digestive system are common worldwide; however, it is extremely rare for more than two malignancies to occur simultaneously. Here, we report a case with a triple malignancy of the digestive system, including gastric, rectal, and hepatic tumors. The patient underwent surgical resection of three tumors followed by chemotherapy. Negative image-based screenings and the absence of serum tumor biomarkers elevation were found at 2.5 years after the surgery, indicating the absence of recurrence and metastasis of cancers.

10.3389/fonc.2022.945689

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Excellent Microwave Absorption Properties Derived from the Synthesis of Hollow Fe3o4@Reduced Graphite Oxide (RGO) Nanocomposites

Nanomaterials (2019)

Guangzhen Cui Yanli Lu Wei Zhou Xuliang Lv Jiangnan Hu

Magnetic nanoparticles, such as Fe₃O₄ and Co₃O₄, play a vital role in the research on advanced microwave absorbing materials, even if problems such as high density and narrow band impedance matching are still unsolved. Herein, the study of lightweight hollow Fe₃O₄@reduced graphite oxide (RGO) nanocomposites synthesized via the solvothermal method is presented. The microstructure and crystal morphology of the materials were characterized by X-ray diffractometer (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analyses. Single crystalline hollow Fe₃O₄ spheres were grown onto RGO flakes, leading to the formation of heterojunction, which further influenced the microwave absorption properties. The latter were evaluated by standard microwave characterization in the frequency range of 2⁻18 GHz. It was found that, for a specific Fe₃O₄@0.125 g RGO composite, the minimum reflection loss can reach -41.89 dB at 6.7 GHz, while the reflection loss was less than -10 dB from 3.4 GHz to 13.6 GHz for a nanocomposite sample thickness in the range of 1⁻4 mm. The combination of these two materials thus proved to give remarkable microwave absorption properties, owing to enhanced magnetic losses and favorable impedance matching conditions.

Reflection loss

Diffractometer

Graphite oxide

10.3390/nano9020141

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Citations (43)

Multifaceted Applications of Ferritin Nanocages in Delivering Metal Ions, Bioactive Compounds, and Enzymes: A Comprehensive Review

Journal of Agricultural and Food Chemistry (2023)

Jiangnan Hu Xinmei Sha Yue Li Jincan Wu Jun‐Rui Ma

Ferritin, a distinctive iron-storage protein, possesses a unique cage-like nanoscale structure that enables it to encapsulate and deliver a wide range of biomolecules. Recent advances prove that ferritin can serve as an efficient 8 nm diameter carrier for various bioinorganic nutrients, such as minerals, bioactive polyphenols, and enzymes. This review offers a comprehensive summary of ferritin's structural features from different sources and emphasizes its functions in iron supplementation, calcium delivery, single- and coencapsulation of polyphenols, and enzyme package. Additionally, the influence of innovative food processing technologies, including manothermosonication, pulsed electric field, and atmospheric cold plasma, on the structure and function of ferritin are examined. Furthermore, the limitations and prospects of ferritin in food and nutritional applications are discussed. The exploration of ferritin as a multifunctional protein with the capacity to load various biomolecules is crucial to fully harnessing its potential in food applications.

Nanocages

Biomolecule

Bioinorganic chemistry

Nanobiotechnology

10.1021/acs.jafc.3c05510

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Recent Advances in Tissue plasminogen activator-based nanothrombolysis for ischemic stroke

REVIEWS ON ADVANCED MATERIALS SCIENCE (2019)

Dongdong Huang Ke Wu Ying Zhang Zhihui Ni Xiaohong Zhu

Abstract Stroke is an acute cerebrovascular disorder caused by sudden decrease or interruption of blood flow in brain arteries. Deficiency of timely and effective reperfusion of ischemic brain tissue can lead to irreversible brain injury and neurological dysfunction. Currently, recombinant tissue plasminogen activator (rt-PA) is the only appropriate thrombolytic agent which is approved by FDA for patients with acute ischemic stoke. However, due to the limitation of very narrow therapeutic time window and severe intracranial hemorrhagic complication, the outcome of stroke treatment mediated by rt-PA still remains unsatisfactory. Therefore, it is urgent to find new alternative drugs or develop novel drug delivery system to achieve better outcomes. In recent years, with the rapid development of nanotechonology, nanomaterials as a drug delivery system can provide new strategies and methods to carry t-PA specifically to the occlusion site and provide advanced treatment for stroke. In this review, we briefly introduced the physiopathologic mechanisms of thrombolysis and focused on the comparison of the t-PA mediated thrombolysis and t-PA conjugated nanomaterial mediated thrombolysis.

Stroke

Acute stroke

Brain tissue

10.1515/rams-2019-0024

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Citations (21)

The Inactivation of JAK2/STAT3 Signaling and Desensitization of M1 mAChR in Minimal Hepatic Encephalopathy (MHE) and the Protection of Naringin Against MHE

Cellular Physiology and Biochemistry (2014)

Saidan Ding Jiangnan Hu Jianjing Yang Leping Liu Weilong Huang

Background: We previously reported that elevation of intracranial dopamine (DA) levels from cirrhotic livers is implicated in the pathogenesis of minimal hepatic encephalopathy (MHE). Intracellular events in neurons, which lead to memory loss in MHE by elevated DA, however, remain elusive. Methods: In our present study, an MHE rat model, a DA - intracerebroventricularly (i.c.v.) injected rat model and DA-treated primary cortical neurons (PCNs) were used to study this issue using behavioral tests, double-labeled fluorescent staining, immunoblotting, and semi-quantitative RT-PCR. Results: Cognitive impairment was observed in MHE rats and DA (10 µg, i.c.v.)-treated rats. The levels of DA in the cerebral cortex of both MHE and DA (10 µg)-treated rats were increased. DA conversely modulated the p-JAK2/p-STAT3 levels in PCNs. In accordance, DA downregulated an anacetylcholine-producing enzyme, choline acetyltransferase (ChAT), and desensitized the M1-type muscarinic acetylcholine receptor (M1 mAChR). Furthermore, naringin completely restored cognitive function in MHE/DA (10 µg)-treated models by activating the JAK2/STAT3 axis, paralleling the upregulation of ChAT and sensitization of M1 mAChR. Conclusions: We propose a hypothesis accounting for memory impairment related to MHE: DA-dependent inactivation of the JAK2/STAT3 axis causes memory loss through cholinergic dysfunction. Our findings provide not only a novel pathological hallmark in MHE but also a novel target in MHE therapy.

Hepatic Encephalopathy

Pathogenesis

10.1159/000366391

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Citations (22)

Chaotrope-Controlled Fabrication of Ferritin–Salvianolic Acid B- Epigallocatechin Gallate Three-Layer Nanoparticle by the Flexibility of Ferritin Channels

Journal of Agricultural and Food Chemistry (2021)

Shengnan Chen Yuqian Liu Lei Zhu Demei Meng Liqun Zhang

Phytoferritin has a natural cagelike architecture for carrying bioactive molecules, and it is uniquely suited to function as a carrier due to its multiple interfaces and channels. In this study, a novel approach was proposed to prepare ferritin-salvianolic acid B-epigallocatechin gallate (EGCG) three-layer nanoparticles (FSE) through the steric hindrance of ferritin channels. Urea (30 mM) could expand the ferritin channel size evidenced by the improved iron release rate vo and promote the EGCG penetration into the ferritin cavity without disassembly of the ferritin cage. The encapsulation ratio of EGCG was 16.0 ± 0.14% (w/w). Salvianolic acid B attached to the outer interface of ferritin through weak bonds with a binding constant of (2.91 ± 0.04) × 105 M-1. The FSE maintained a spherical structure with a diameter of 12 nm. Moreover, when subjected to heat (40-70 °C) there was a significant increase in the stability of EGCG in the FSE due to the binding of salvianolic acid B. Through this interesting approach, two molecules are simultaneously attached and encapsulated in ferritin in a multilayer form under moderate conditions, which is conducive to the protection of unstable molecules for potential encapsulation and delivery utilization.

10.1021/acs.jafc.1c01997

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Citations (8)