Vesna Pirec

Centers for Behavioral Health

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David C. Yeomans

Stanford University

Maria Muzik

University of Michigan–Ann Arbor

J. Lance Lichtor

Yale University

Prabha S. Chandra

National Institute of Mental Health and Neurosciences

Dennis W. Coalson

University of Chicago

Jerome M. Klafta

University of Chicago

Jeffrey L. Apfelbaum

University of Chicago

Carol Henshaw

University of Liverpool

Ying Lü

Shenzhen Second People's Hospital

Pankaj Thapar

University of Chicago

Cooperative Institutions

University of Chicago

University of Illinois Chicago

Committee on Publication Ethics

National Institute on Drug Abuse

Brain Research Foundation

Creative Commons

University of Michigan–Ann Arbor

University of Chicago Medical Center

University of Iowa

National Institute of Mental Health and Neurosciences

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Perinatal mental health in primary care: An overview of current models across the globe

CRC Press eBooks (2022)

Maria Muzik Susan Hamilton Tamsen Rochat Jane RW Fishe Bryanne Barnett

Primary health-care practitioners are trained to recognize common mental health problems in women, to provide first-line treatments for those with mild to moderate problems, and referral to specialist psychiatric care for those with more severe problems. Research about the perinatal mental health of women living in resource-constrained countries has only been conducted more recently, with most studies being published since 2000. This is in part because of competing health priorities, including high rates of maternal deaths from obstetric emergencies, and limited local research resources and capacity. In Africa, the burden of depression and poor maternal mental health most likely relates to women's exposure to multiple depression-related risk factors such as extreme poverty, violence, displacement, migration and the increasing threat of human immunodeficiency virus and acquired immunodeficiency syndrome. Ensuring that women in need of perinatal mental health care receive adequate services is a challenge across the globe.

Globe

10.1201/9781846198465-27

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Current Dilemmas in Treating Depressed Pregnant Patients

Psychopharm Review (2007)

Vesna Pirec

Learning Objectives fter reading this article, the practitioner should be able to: Discuss the assessment of depression in pregnant women and treatment approaches. Describe potential risks of using selective serotonin reuptake inhibitors in pregnant patients. Summarize basic concepts regarding treatment decisions in pregnant patients with depression.

Depression

10.1097/01.idt.0000299133.95994.b1

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Differential antinociceptive effects of spinal opioids on foot withdrawal responses evoked by C fibre or Aδ nociceptor activation

British Journal of Pharmacology (1997)

Ying Lü Vesna Pirec David C. Yeomans

Intrathecal application of μ, δ, and κ opioids attenuate responses on several tests of animal nociception. However, the potency of these opioids differ depending on which tests were used. One factor contributing to these discrepancies is that different types of noxious stimuli activate different sets of nociceptor types, which may be differentially sensitive to opiate inhibition. To examine this hypothesis, we used a recently developed behavioural test which allows for differential assessment of nociception evoked by the activation of myelinated (Aδ) and unmyelinated C thermonociceptors. Administration of a κ‐selective agonist was ineffective on either type of response. δ 1 drugs were slightly more potent on C fibre‐mediated responses than on Aδ‐mediated responses. Intrathecal μ and δ 2 drugs were antinociceptive on both Aδ and C nociceptor‐mediated responses. However, unlike the δ 1 effects, the dose‐response curves for μ and δ 2 drugs were significantly more steep for Aδ than for C fibre‐mediated responses, potentially indicating differences in the mechanisms by which the drugs act on these 2 response types.

Nociceptor

10.1038/sj.bjp.0701239

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Citations (34)

Cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers.

Experimental and Clinical Psychopharmacology (1995)

Vesna Pirec Dennis W. Coalson J. Lance Lichtor Jerome M. Klafta et al

Nitrous oxide

Immersion

10.1037//1064-1297.3.2.148

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Citations (6)

Integrative Approaches to Perinatal Depression

CRC Press eBooks (2015)

Vesna Pirec Kelly Brogan

Depression

10.1201/b19089-29

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Citations (0)

New Mothers with Disturbing Thoughts: Treatment of Obsessive-Compulsive Disorder and of Psychosis in Postpartum

Springer eBooks (2017)

Vesna Pirec Agnieszka Grabowski

Presentation (obstetrics)

Postpartum psychosis

Case presentation

10.1007/978-3-319-40404-2_4

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Perinatal mental health in primary care: an overview of current models across the globe

Maria Muzik Susan Hamilton Tamson Jean Rochat Jane Fisher Bryanne Barnett

Globe

Source

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Citations (1)

Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence

Pain (1996)

David C. Yeomans Vesna Pirec Herbert K. Proudfit

Several lines of evidence suggest that different classes of nociceptive afferents mediate the responses produced by different rates of noxious skin heating. More specifically, low skin heating rates evoke nociceptive responses that appear to be mediated by the activation of capsaicin-sensitive C-fiber nociceptors, whereas high skin heating rates appear to produce responses mediated by the activation of other nociceptors. This hypothesis was examined by both electrophysiological and behavioral experiments. This report describes the results of experiments designed to determine whether pharmacologic treatments that selectively alter the activity of C-fiber nociceptive afferents also produce selective effects on foot withdrawal responses to either high or low rates of noxious foot heating. The results these experiments demonstrate that: (1) topical application of a low concentration of capsaicin, which sensitizes C-fiber nociceptors, selectively decreased the latency of responses to low heating rates; (2) topical application of a high concentration of capsaicin, that desensitizes C-fiber nociceptors, selectively increased the latency of responses to low heating rates; (3) low doses of systemic morphine, which selectively attenuate nociception produced by the activation of C-fiber nociceptors, selectively increased response latencies for low skin heating rates. These results support the conclusion that foot withdrawal responses evoked by low skin heating rates are mediated by the activation of capsaicin-sensitive C-fiber nociceptors and foot withdrawal responses evoked by high skin heating rates are mediated by the activation of other nociceptors. This conclusion is supported by the results of the accompanying electrophysiological study which provides direct evidence that low rates of skin heating preferentially activate C-fiber nociceptors while high rates of skin heating preferentially activate Aδ nociceptors.

Nociceptor

Capsaicin

10.1016/s0304-3959(96)03176-4

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Citations (394)

https://researchopenworld.com/perinatal-mental-health-care-across-the-globe/#

Maria Muzik Vesna Pirec Jonathan E. Handelzalts Ashlesha Bagadia Florence Gressier

The perinatal period is a vulnerable time for new mothers and their families.Broad public awareness and universal health education for all new mothers about perinatal mental illness carries significant impact.Timely screening for mental health disorders in pregnancy and postpartum is essential, followed by referrals to adequate treatments.Integrative care plays a significant role in enhancing reach and uptake.Stepped care models propose a range of treatment options based on symptoms and illness severity, and yield the most optimal outcomes for affected mothers and their children.Perinatal psychiatry, including integrative perinatal care, has over the past decades received more attention and resource allocation worldwide.But today various countries, based on their history of awareness and stigma towards perinatal illnesses, their access to overall mental health care, especially perinatal, based on insurance/payment coverage and established workforce, and based on overall national priorities and economic strength, face various challenges to establish comprehensive and systemic pathways of care for perinatal women suffering mental health challenges.Overall, there is still significant inequality across the globe both in low-and high-income countries in public awareness, infrastructure, and access, and there is still a long way to go to ease the suffering for affected perinatal women and their families.

Globe

Mental Health Care

10.31038/awhc.2019251

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Citations (1)

Stressful Conditions Affect Acceptance of Nitrous Oxide in Humans

Anesthesiology (1994)

J P Zacny Vesna Pirec Gita Rupani Pankaj Thapar J. Klafia

Nitrous oxide

Affect

10.1097/00000542-199409001-00045

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Citations (1)