Abstract Aim: To clarify the clinical significance of acanthosis nigricans (AN) and the association of gene polymorphisms in the β2‐ and β3‐adrenergic receptors (B2ADR and B3ADR) in Japanese obese children and adolescents. Methods: Seventy obese subjects (56 boys, 14 girls) from 5 to 19 y of age were examined as to clinical features. Genetic analyses were performed in 83 obese subjects (61 boys, 22 girls), 2 to 17 y of age. Typing of gene polymorphisms in B2ADR and B3ADR was achieved by polymerase chain reaction (PCR) of genomic DNA and restriction fragment‐length polymorphism analysis (PCR‐RFLP). Results: The group with AN ( n =30) had higher values for percent overweight, BMI, waist circumference, fasting insulin, HOMA‐R, leptin and PAI‐1 than the AN‐negative group ( n =40), but there were no significant differences in age, sex or percent body fat between the two groups. The prevalences of B2ADR Gly16 and B3ADR Arg64 were significantly higher in AN‐positive ( n =26) than in AN‐negative ( n =57) subjects. In addition, the AN frequency was significantly higher in the group with both Gly16 and Arg64 than in the group with neither of these alleles (55.6% vs 12.5%, p < 0.05). Conclusion: We demonstrate that AN is a useful clinical marker for the severity of obesity associated with a high BMI, and that B2ADR Gly16 and B3ADR Arg64 are associated synergistically with AN in obese children and adolescents.
Journal Article Granulocyte colony-stimulating factor in acute myeloid leukemia Kensuke Usuki, Kensuke Usuki Division of Hematology, Kanto Teishin Hospital, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar Seiko Iki, Seiko Iki Division of Hematology, Kanto Teishin Hospital, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar Mitsue Endo, Mitsue Endo Division of Hematology, Kanto Teishin Hospital, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar Koichi Kitazume, Koichi Kitazume Division of Hematology, Kanto Teishin Hospital, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar Keiko Ito, Keiko Ito Division of Hematology, Kanto Teishin Hospital, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar Masahiko Watanabe, Masahiko Watanabe Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar Akio Urabe Akio Urabe Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Tokyo, Japan Correspondence: Dr. Akio Urabe, Division of Hematology, Kanto Teishin Hospital, 5–9–22 Higashi-Gotanda, Shinagawa-ku, Tokyo, Japan 141. Search for other works by this author on: Oxford Academic Google Scholar Stem Cells, Volume 13, Issue 6, January 1995, Pages 647–654, https://doi.org/10.1002/stem.5530130609 Published: 01 January 1996 Article history Received: 27 March 1995 Accepted: 21 July 1995 Published: 01 January 1996
Background: The reddening of the face and neck following alcohol consumption is known as Asian flush. Although genetic factors related to Asian flush have been reported to be inversely associated with duration of sleep, no study has reported an association between Asian flush and sleep satisfaction. Methods: A cross-sectional study of 3823 Japanese people, aged 20 to 64 years was conducted. The target population comprised general public resident monitors of Osaka Prefecture who were registered with an internet research company. Results: A significant inverse association was observed between Asian flush and satisfaction of sleep. The potential confounder-adjusted odds ratio (OR) and 95% confidence interval (CI) of satisfied sleep was 0.81 (0.69–0.96). The alcohol consumption status-specific analysis revealed essentially the same associations between consumers and non-consumers of alcohol. The adjusted ORs (95% CIs) were 0.81 (0.65–0.997) for non-consumers and 0.80 (0.61–1.05) for consumers of alcohol. Conclusion: The genetic characteristics of physical reactions to alcohol exposure may influence sleep quality. One’s alcohol consumption status may not influence the effects of having a lower tolerance to alcohol on sleep quality.
