ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative microdialysis under transient conditionsR. J. Olson and J. B. JusticeCite this: Anal. Chem. 1993, 65, 8, 1017–1022Publication Date (Print):April 15, 1993Publication History Published online1 May 2002Published inissue 15 April 1993https://pubs.acs.org/doi/10.1021/ac00056a012https://doi.org/10.1021/ac00056a012research-articleACS PublicationsRequest reuse permissionsArticle Views331Altmetric-Citations122LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fundamentals of in Vivo Voltammetry.- to In Vivo Voltammetry.- Molecular Specificity of In Vivo Electrochemical Measurements.- Quantitative Interpretations of In Vivo Chronoamperometry: Clues Toward Understanding the Spatial and Tempoaral Influences of Dopamine.- Application to the Neurochemistry of Catecholamines.- In Vivo Electrochemical Monitoring of Dopamine Release.- Monitoring Extracellular DOPAC Following Stimulated Release of Dopamine.- In Vivo Voltammetry: Application to the Identification of Dopamine and 5-Hydroxytryptamine Receptors.- Study of Brain Noradrenergic Neurons by Use of In Vivo Voltammetry.- Probing Pathways of Neuroendocrine Regulation With Voltammetric Microelectrodes.- Voltammetry and Behavior.- Application of In Vivo Voltammetry to Behavioral Pharmacology.- Excitatory Amino Acid Release, Dopamine Release, and Uric Acid Levels Monitored Simultaneously Using Linear Sweep Voltammetry in the Unrestrained Rat.- In Vivo Voltammetry and the Neurochemical Control of Movement and Blood Pressure.
A system for reducing the necessary number of GC liquid phases is proposed. A set of twelve preferred liquid phases is given and a nearest neighbor technique is used to show correlations in the comprehensive tabulation of liquid phase data published by McReynolds. The nearest neighbor technique is also used to decide which of the preferred phases can best be substituted for most of the phases currently in use.
Abstract Rats were treated for 10 days with cocaine (20 mg/kg, i.p.) followed by either 1 or 10 days of abstinence. On the test day a microdialysis method was performed in which dopamine (DA) was added to the perfusate at concentrations above and below the expected extracellular concentration (0, 2.5, 5, and 10 nM) to generate a series of points that can be interpolated to determine the concentration of no net flux, which represents the extracellular DA concentration. The slope of the line generated by this method is the in vivo recovery of the dialysis probe. After 1 day of abstinence, there was no significant difference in basal DA levels in the nucleus accumbens (N ACC) between cocaine treated (4.1 ± 0.3 nM; mean ± SEM) and saline‐treated (3.9 ± 0.2 nM) groups. However, there was a significant increase in the slope of the cocaine‐treated group (0.91 ± 0.04 vs. 0.67 ± 0.08; P >0.03). After 10 days of abstinence, there were reduced basal extracellular levels of DA in the N ACC of the cocaine‐treated group as compared with saline‐treated controls ( P <0.002). The basal extracellular DA concentration in the N ACC was 2.1 ± 0.3 nM for the cocaine group and 3.9 ± 0.2 nM for the control group. The slopes of the curves were not significantly different for the cocaine (0.63 ± 0.07) and saline (0.64 ± 0.09) groups. There was a significant interaction between cocaine and the length of abstinence with respect to the reduction in basal extracellular DA in the N ACC ( P <0.0008) and also an interaction between cocaine and the length of abstinence with respect to the slope of the regression lines ( P <0.03). The results suggest that both basal levels and the dynamics of extracellular DA in the N ACC are altered by chronic cocaine. These alterations may have relevance to the dopamine depletion hypothesis of cocaine addiction.
