Iman H. Brivanlou

Howard Hughes Medical Institute

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Thomas A. Jordan

Stanford University

Markus Meister

California Institute of Technology

Mark S. Goldman

University of California, Davis

Jorge Golowasch

New Jersey Institute of Technology

L. F. Abbott

Columbia University

Alain Destexhe

Institut des Neurosciences Paris-Saclay

Clair Kelley

St. Jude Children's Research Hospital

Edward M. Callaway

Salk Institute for Biological Studies

Eve Marder

Brandeis University

Daniel S. Kessler

University of Pennsylvania

Cooperative Institutions

Harvard University

Howard Hughes Medical Institute

Boston Children's Hospital

Salk Institute for Biological Studies

Rutgers, The State University of New Jersey

Brandeis University

University of California, Berkeley

University of California, San Diego

University of California, San Francisco

Harvard University Press

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Mechanisms of Concerted Firing among Retinal Ganglion Cells

Neuron (1998)

Iman H. Brivanlou David K. Warland Markus Meister

Retinal waves

Electrical Synapses

Parasol cell

Darkness

10.1016/s0896-6273(00)80992-7

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Citations (236)

TGF-β signals and a prepattern in Xenopus laevis endodermal development

Development (1996)

Gilbert L. Henry Iman H. Brivanlou Daniel S. Kessler Ali Hemmati‐Brivanlou Douglas A. Melton

ABSTRACT We have analyzed two gene products expressed in the early endoderm of Xenopus laevis: Xlhbox-8, a pancreas-specific transcription factor and intestinal fatty acid binding protein (IFABP), a marker of small intestinal epithelium. Expression of the pancreas marker relies on cell signaling mediated by both the TGFβ and FGF classes of secreted peptide growth factors, whereas, expression of the more posterior small intestinal marker does not. Endodermal explants devoid of mesoderm express both markers in a regionalized manner. Cortical rotation is required for the expression of the more anterior marker, Xlhbox-8, but not for the small intestinal marker, IFABP. These findings suggest that endodermal patterning is dependent, in part, on the same events and signals known to play important roles in mesodermal development. Furthermore, inhibition of TGFβ signaling in the endoderm leads to ectopic expression of both mesodermal and ectodermal markers, suggesting that TGFβ signaling may play a general role in the segregation of the three embryonic germ layers.

10.1242/dev.122.3.1007

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Citations (196)

Neuronal Computations with

Jorge Golowasch Mark S. Goldman L. F. Abbott Eve Marder M. J. Berry

Source

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Citations (1)

Topographic specificity of functional connections from hippocampal CA3 to CA1

Proceedings of the National Academy of Sciences (2004)

Iman H. Brivanlou Jami L. Dantzker Charles F. Stevens Edward M. Callaway

The hippocampus is a cortical region thought to play an important role in learning and memory. Most of our knowledge about the detailed organization of hippocampal circuitry responsible for these functions is derived from anatomical studies. These studies present an incomplete picture, however, because the functional character and importance of connections are often not revealed by anatomy. Here, we used a physiological method (photostimulation with caged glutamate) to probe the fine pattern of functional connectivity between the CA3 and CA1 subfields in the mouse hippocampal slice preparation. We recorded intracellularly from CA1 and CA3 pyramidal neurons while scanning with photostimulation across the entire CA3 subfield with high spatial resolution. Our results show that, at a given septotemporal level, nearby CA1 neurons receive synaptic inputs from neighboring CA3 neurons. Thus, the CA3 to CA1 mapping preserves neighbor relations.

Photostimulation

Nerve net

10.1073/pnas.0308577100

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Citations (47)

BMP-4-responsive regulation of dorsal–ventral patterning by the homeobox protein Mix.1

Nature (1996)

Paul E. Mead Iman H. Brivanlou Clair Kelley Leonard I. Zon

Homeobox protein Nkx-2.5

Ectopic expression

DLX5

10.1038/382357a0